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Did you mean miR-21?

GlossarymiR-21

small RNA molecule regulating gene expression and hair follicle development

miR-21 is a type of microRNA, which are small molecules that help regulate gene expression in cells. It is known to play a role in various biological processes, including cell growth, apoptosis (programmed cell death), and differentiation. In the context of hair and alopecia, miR-21 has been implicated in the regulation of hair follicle development and cycling, and its dysregulation may contribute to hair loss conditions.

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Melatonin Regulates the Mitogen-Activated Protein Kinase Pathway via the CircMPP5-miR-211-MAPK3 Axis to Induce Secondary Hair Follicle Differentiation and Development in Newborn Cashmere Goat Kids

research Melatonin regulates the mitogen-activated protein kinase ( MAPK ) pathway via the circMPP5-miR-211-MAPK3 axis to induce secondary hair follicle differentiation and development in newborn Cashmere goat kids

1 citations , October 2022 in “Research Square (Research Square)”

Melatonin helps improve Cashmere goat hair quality by promoting hair follicle growth through a specific cell signaling pathway.

research MiR-23b and miR-133 Cotarget TGFβ2/NOTCH1 in Sheep Dermal Fibroblasts, Affecting Hair Follicle Development

4 citations , March 2024 in “Cells”

MiR-23b and miR-133 affect sheep hair growth by targeting specific genes.

Melatonin Promotes the Development of Secondary Hair Follicles by Regulating circMPP5

research Melatonin promotes the development of the secondary hair follicles by regulating circMPP5

1 citations , April 2023 in “Journal of Animal Science and Biotechnology”

Melatonin helps grow more secondary hair follicles in young goats, improving cashmere production.

research Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

65 citations , July 2020 in “Science Advances”

Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.

research The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat

13 citations , September 2018 in “Scientific Reports”

The research found that a complex gene network, controlled by microRNAs, is important for hair growth in cashmere goats.

research 192 MicroRNAs and their regulatory interactions in the human hair follicle

August 2016 in “Journal of Investigative Dermatology”

The research found that certain microRNAs are important for human hair growth and health.

research A Concise Review on Biological Activity of Tridax procumbens Linn

1 citations , January 2017 in “Organic chemistry”

Tridax procumbens has medicinal properties like healing, pain relief, and infection control.

research miR-29 is an important driver of aging-related phenotypes

2 citations , December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

miR-29 is a key factor that accelerates aging.

research miR‐218‐5p regulates skin and hair follicle development through Wnt/β‐catenin signaling pathway by targeting SFRP2

54 citations , April 2019 in “Journal of cellular physiology”

miR-218-5p helps skin and hair growth by targeting SFRP2 and activating a specific signaling pathway.

research Chi-miR-30b-5p inhibits dermal papilla cells proliferation by targeting CaMKIIδ gene in cashmere goat

13 citations , June 2020 in “BMC genomics”

A specific microRNA, chi-miR-30b-5p, slows down the growth of hair-related cells by affecting the CaMKIIδ gene in cashmere goats.

research miR-195-5p Regulates Hair Follicle Inductivity of Dermal Papilla Cells by Suppressing Wnt/β-Catenin Activation

19 citations , January 2018 in “BioMed Research International”

miR-195-5p reduces hair growth ability in cells by blocking a specific growth signal.

research LncRNA-XIST promotes dermal papilla induced hair follicle regeneration by targeting miR-424 to activate hedgehog signaling

11 citations , March 2020 in “Cellular Signalling”

XIST RNA helps regenerate hair follicles by targeting miR-424 and activating hedgehog signaling.

research Regulation of somatic cell reprogramming through inducible mir-302 expression

308 citations , September 2010 in “Nucleic acids research”

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

research Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

54 citations , November 2017 in “Scientific Reports”

The study found that certain microRNAs are higher in the cells and lower in the fluid of women with a specific type of polycystic ovary syndrome, and one microRNA could potentially help diagnose the condition.

MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

research miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

18 citations , December 2020 in “Frontiers in cell and developmental biology”

miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.

LncRNA-599547 Contributes to the Inductive Property of Dermal Papilla Cells in Cashmere Goats Through miR-15b-5p/Wnt10b Axis

research LncRNA-599547 contributes the inductive property of dermal papilla cells in cashmere goat through miR-15b-5p/Wnt10b axis

7 citations , August 2020 in “Animal biotechnology”

A specific RNA in cashmere goats helps improve hair growth by interacting with certain molecules.

research Hair Dermal papilla maintain its hair inducing characteristics via autocrine exosomal miR-23a-3p

July 2025

Hair growth is maintained by specific cell signals.

research Whole-genome SNP genotyping mapped a novel locus for hereditary hypotrichosis on chromosome 2q31.1–q32.2

May 2015 in “Journal of Dermatological Science”

Researchers found a new area on chromosome 2 linked to a genetic hair loss condition.

Pharmacological Targeting Strategies of Pancreatic Beta Cells for Type 2 Diabetes Therapy

research Strategie di targeting farmacologico delle beta-cellule pancreatiche per la terapia del diabete mellito di tipo 2

January 2025 in “il Diabete”

Targeted drug delivery to pancreatic beta-cells can improve type 2 diabetes treatment.

research miR-370-3p Inhibited the Proliferation of Sheep Dermal Papilla Cells by Inhibiting the Expression of SMAD4

4 citations , May 2025 in “Cells”

miR-370-3p slows sheep hair cell growth by blocking SMAD4.

research Low-frequency electromagnetic fields ameliorate testosterone-induced androgenetic alopecia in mice through LncRNA H19/miR-214-5p/β-catenin signal pathway

January 2026 in “Regenerative Therapy”

Low-frequency electromagnetic fields may help treat hair loss by promoting hair regrowth.

research Analysis of the microRNA expression profile of normal human dermal papilla cells treated with 5α-dihydrotestosterone

22 citations , March 2012 in “Molecular Medicine Reports”

DHT affects hair follicle cells by changing microRNA levels, leading to less cell growth and more cell death.

research Transcriptional Characteristics Showed That miR-144-y/FOXO3 Participates in Embryonic Skin and Feather Follicle Development in Zhedong White Goose

46 citations , August 2022 in “Animals”

miR-144-y and FOXO3 play key roles in skin and feather development in Zhedong White geese.

research MiR-325-3p functions as a suppressor miRNA and inhibits the proliferation and metastasis of glioma through targeting FOXM1

16 citations , December 2021 in “Journal of Integrative Neuroscience”

miR-325-3p can slow down brain tumor growth by targeting FOXM1.

research LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells

12 citations , August 2020 in “Frontiers in Genetics”

H19 boosts hair growth potential by activating Wnt signaling, possibly helping treat hair loss.

research A functional polymorphism in interleukin-1α (IL1A) gene is associated with risk of alopecia areata in Chinese populations

11 citations , March 2013 in “Gene”

A certain genetic variation in the IL1A gene may lower the risk of a hair loss condition in Chinese people.

Detection of Hair MicroRNAs as Novel Potent Biomarkers: Evaluation of Usefulness for Scleroderma Diagnosis

research Detection of hair-microRNAs as the novel potent biomarker: Evaluation of the usefulness for the diagnosis of scleroderma

39 citations , July 2013 in “Journal of dermatological science”

Hair microRNAs could be effective biomarkers for diagnosing scleroderma.

research Prenatal Exposure to Delta-9-tetrahydrocannabinol (THC) Alters the Expression of miR-122-5p and Its Target Igf1r in the Adult Rat Ovary

9 citations , July 2022 in “International Journal of Molecular Sciences”

Prenatal THC exposure may harm ovarian health and fertility.

research MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2

123 citations , November 2012 in “Stem cells”

MicroRNA-302 helps improve the conversion of body cells into stem cells by blocking NR2F2.

research MicroRNA/mRNA regulatory networks in the control of skin development and regeneration

56 citations , February 2012 in “Cell Cycle”

MicroRNAs are crucial for controlling skin development and healing by regulating genes.