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GlossaryMononuclear Cells

white blood cells with a single round nucleus

Mononuclear cells, also known as mononuclear leukocytes or MNCs, are a type of white blood cell characterized by having a single round nucleus. These cells include lymphocytes and monocytes, which play crucial roles in the immune system by fighting infections and aiding in immune responses.

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Impaired Responses of Peripheral Blood Mononuclear Cells to T-Cell Stimulants in Alopecia Areata Patients with a Poor Response to Topical Immunotherapy

research Impaired responses of peripheral blood mononuclear cells to T-cell stimulants in alopecia areata patients with a poor response to topical immunotherapy

4 citations , July 2008 in “British journal of dermatology/British journal of dermatology, Supplement”

Poor response to topical immunotherapy in alopecia areata patients is linked to impaired cell responses.

Uncontrolled Clinical Trial of Quality- and Quantity-Cultured Peripheral Blood Mononuclear Cell Treatment for Androgenic Alopecia

research Uncontrolled Clinical Trial of Quality- and Quantity-cultured Peripheral Blood Mononuclear Cell Treatment for Androgenic Alopecia

October 2025 in “Plastic & Reconstructive Surgery”

MNC-QQ cell therapy improved hair growth and quality of life in men with androgenic alopecia without adverse effects.

research 058 Subset analysis of NKG2D+ cells in peripheral blood mononuclear cells

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The study suggests that a specific type of immune cell, memory-like NK cells, may increase during active hair loss in Alopecia areata.

research Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata

12 citations , March 2016 in “BBA clinical”

Increased Toll-like receptors in blood cells may contribute to alopecia areata and could be a target for new treatments.

Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata

research Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells of a Healthy Donor on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata: Targeting Dysregulated T Cells and the Acquisition of Immunotolerance

1 citations , October 2022 in “International Journal of Molecular Sciences”

Using healthy donor stem cells can potentially calm overactive immune cells and reduce inflammation in severe hair loss patients, offering a possible treatment method.

Availability of mRNA from Peripheral Blood Mononuclear Cells for Mutational Analysis in Dystrophic Epidermolysis Bullosa

research 302 Availability of mRNA Obtained from Peripheral Blood Mononuclear Cells for Mutational Analysis in Dystrophic Epidermolysis Bullosa

November 2022 in “Journal of Investigative Dermatology”

Scientists developed a new way to study mutations in a skin condition using blood cells, which may help diagnose and treat the disease.

research Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata

48 citations , September 2011 in “British Journal of Dermatology”

Epigenetic changes in blood cells may contribute to alopecia areata.

research The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring

1 citations , March 2023 in “Pharmaceutics”

PBMCsec can help reduce and improve thick skin scars.

To Identify the Expression of Intracellular Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Alopecia Areata

research TO IDENTIFY THE EXPRESSION OF INTRACELLULAR TOLL-LIKE RECEPTORS (TLRS) IN PERIPHERAL BLOOD MONONUCLEAR CELLS OF ALOPECIA AREATA

November 2023

Alopecia areata patients have higher levels of certain immune receptors, suggesting new treatment possibilities.

research Role of Cytotoxic T Cells in Chronic Alopecia Areata

127 citations , January 2000 in “Journal of Investigative Dermatology”

Cytotoxic T cells cause hair loss in chronic alopecia areata.

research Hair regrowth in alopecia areata patients following Stem Cell Educator therapy

55 citations , April 2015 in “BMC medicine”

Stem Cell Educator therapy helps regrow hair and improve life quality in alopecia areata patients.

The Effect of Mesenchymal Stem Cell-Conditioned Medium Gel on Burn Wound Healing in Rats

research The effect of mesenchymal stem cell-conditioned medium gel on burn wound healing in rat

3 citations , April 2022 in “Veterinary world/Veterinary World”

The mesenchymal stem cell-conditioned medium gel improved burn healing and hair growth in rats better than other treatments.

research Oral syphilis: report of three cases and characterization of the inflammatory cells

32 citations , January 2015 in “Annals of diagnostic pathology”

The document concludes that recognizing oral lesions is important for diagnosing syphilis.

research Melan-A Positive cells significantly expressed in immune-targeted follicles of Alopecia Areata

August 2023 in “Research Square (Research Square)”

Melanocytes may trigger the immune response in alopecia areata, affecting hair regrowth.

research scMC learns biological variation through the alignment of multiple single-cell genomics datasets

822 citations , January 2021 in “Genome biology”

scMC effectively separates biological signals from technical noise in single-cell genomics data.

research Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege

53 citations , September 2013 in “Journal of Investigative Dermatology”

Hair follicle cells help protect against immune attacks by regulating T-cell activity.

research Stem cell therapy as a novel therapeutic intervention for resistant cases of alopecia areata and androgenetic alopecia

39 citations , August 2016 in “Journal of Dermatological Treatment”

Stem cell therapy may help treat tough hair loss cases.

research iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata

27 citations , April 2018 in “Journal of autoimmunity”

iNKT cells can help prevent and treat alopecia areata by promoting hair regrowth.

research Table 1_Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata.docx

July 2025 in “Figshare”

Alopecia areata involves immune system changes, especially in severe cases, with potential new treatment targets identified.

research 164 Epigenetic and transcriptional profiling of PBMCs in mild and severe alopecia areata using single-cell RNA-Seq and ATAC-Seq

November 2023 in “Journal of Investigative Dermatology”

The study identified key immune cell differences between mild and severe alopecia areata.

research 586 Increase in CD8+ effector memory cells re-expressing CD45RA (TEMRA) reflects disease activity and enables early prediction of therapeutic outcome in rapidly progressive alopecia areata

April 2023 in “Journal of Investigative Dermatology”

Increased TEMRA cells can predict treatment outcomes in rapidly progressive alopecia areata.

research 004 Cell-based therapy may be effective in alopecia areata: Preclinical evidence that autologous, peripheral regulatory γdT cells are preventive in human ex vivo and therapeutic in human in vivo models

November 2022 in “Journal of Investigative Dermatology”

Cell-based therapy using specific immune cells may help treat alopecia areata by promoting hair regrowth.

research Application of genetically modified umbilical cord blood cells and direct gene therapy for treatment of skin wounds in rats

September 2014 in “Genes and Cells”

Genetically modified umbilical cord blood cells improved skin wound healing in rats.

Acute Diffuse And Total Alopecia: A New Subtype Of Alopecia Areata With A Favorable Prognosis

research Diffuse Alopecia Areata

2 citations , January 2018

Diffuse alopecia areata causes widespread hair thinning due to an autoimmune response.