92 citations
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June 2005 in “Journal of Investigative Dermatology” All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.
April 2018 in “Journal of Investigative Dermatology” The conclusion is that a new method combining magnetic tweezers and traction force microscopy may help understand skin cell interactions and diseases.
July 2019 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Activin A speeds up ear hair cell differentiation, while Follistatin slows it down.
January 2008 in “Journal of The American Academy of Dermatology” ROS may affect hair loss related to hormones.
20 citations
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June 2019 in “JAAD Case Reports” Tofacitinib can cause skin eruptions similar to palmoplantar pustulosis.
4 citations
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May 2022 in “Genes & Diseases” 2 citations
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September 2024 in “Biomedical Research and Therapy” MSCs should be called "master signaling cells" because they mainly help with cell communication and tissue repair.
9 citations
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May 2014 in “Journal of Cardiovascular Development and Disease” Wnt/β-catenin signaling is crucial for heart development and could help improve heart repair.
5 citations
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January 2016 in “Journal of Molecular Histology” Both main and alternative Wnt signaling are important for regrowing rodent whisker follicles.
127 citations
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July 2002 in “EMBO journal” Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.
13 citations
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March 2021 in “British Journal of Pharmacology” KY19382 helps regrow hair and create new hair follicles.
25 citations
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January 2019 in “Annals of Dermatology” Blocking the NOTCH pathway can prevent fibrosis in systemic sclerosis.
24 citations
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September 2019 in “Experimental cell research” BMP2 helps hair follicle stem cells become specialized by increasing PTEN, which causes autophagy.
September 2024 in “Journal of Cosmetic Dermatology” Ectoin helps prevent cortisone-induced skin problems and supports skin health.
July 2024 in “Journal of Investigative Dermatology” Mechanical tension worsens keloid scars by activating inflammation and fibrosis pathways.
27 citations
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September 2017 in “Archives of Dermatological Research” Topical tofacitinib may grow hair better than minoxidil by increasing VEGF and reducing inflammation.
August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Axolotls regenerate their spinal cord through a signal that recruits cells, influenced by cell sensitivity and signal spread.
26 citations
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June 2024 in “Frontiers in Immunology” SOCS1 and SOCS3 help control skin inflammation and are important for developing treatments for skin diseases.
22 citations
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November 2002 in “Clinical journal of oncology nursing” Arsenic trioxide effectively treats relapsed acute promyelocytic leukemia with manageable side effects.
11 citations
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August 2021 in “Stem Cell Research & Therapy” The study found that pimecrolimus, a calcineurin inhibitor used for atopic dermatitis (AD), reduced the therapeutic efficacy of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in a mouse model. Pimecrolimus interfered with the stem cells' ability to modulate immune responses by inhibiting the nuclear translocation of NFAT3, crucial for COX2-mediated immunomodulation. This disruption affected the reduction of epidermal thickness and mast cell infiltration, key therapeutic effects of hUCB-MSCs. The findings highlighted the importance of considering drug interactions in MSC-based therapies for AD, as the combination therapy was less effective than hUCB-MSCs alone.
1 citations
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July 2019 in “Medicina Clínica (English Edition)” Tofacitinib partially improved hair regrowth in a patient with severe hair loss.
92 citations
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July 2001 in “The FASEB Journal” Overexpressing the glucocorticoid receptor in mice leads to abnormal skin development and reduced inflammation.
1 citations
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January 2005 in “Experimental Dermatology” MC-1R in skin cells may influence inflammation and collagen production.
5 citations
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November 2013 in “Journal of Investigative Dermatology” The glucocorticoid receptor helps protect skin from tumors and other issues.
182 citations
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November 2017 in “Molecular Aspects of Medicine” The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.
81 citations
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September 2005 in “The American journal of pathology” Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.
1 citations
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July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” Tofacitinib helps improve skin conditions in people with Down syndrome, especially alopecia areata.
March 2024 in “Research Square (Research Square)” The TT genotype of a specific SNP in sheep is linked to better wool quality.
148 citations
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October 1997 in “Journal of Investigative Dermatology” 76 citations
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January 1998 in “Mammalian Genome”