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GlossaryMyelin Protein Zero-Like 3

protein involved in hair follicle development and maintenance

Myelin Protein Zero-Like 3 (MPZL3) is a protein that plays a role in the development and maintenance of hair follicles. It is involved in cellular adhesion and signaling processes that are crucial for hair growth and regeneration. Mutations or dysregulation of MPZL3 can lead to hair disorders, including certain types of alopecia.

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Genetic Ablation of Myelin Protein Zero-Like 3 in Mice Increases Energy Expenditure, Improves Glycemic Control, and Reduces Hepatic Lipid Synthesis

research Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis

14 citations , May 2013 in “American Journal of Physiology-endocrinology and Metabolism”

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.

research 548 Deletion of Myelin Protein Zero-like 3 increases sebaceous gland size and sebocyte proliferation but reduces skin adipose depots: Can MPZL3 inhibition promote excessive loss of lipids via sebum hypersecretion?

November 2022 in “Journal of Investigative Dermatology”

Deleting MPZL3 increases skin oil production and reduces body fat.

research 583 Hair cycle regulation by a mitochondrially localized protein: Is MPZL3 a central component of the elusive hair cycle clock?

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

MPZL3 protein is important for controlling hair growth cycles.

research 811 Mitochondrial MPZL3 in the inner root sheath regulates human hair follicle cycling ex vivo

1 citations , July 2024 in “Journal of Investigative Dermatology”

MPZL3 protein affects hair growth cycles and could help manage hair loss.

research 1433 Epithelially derived, mitochondrial MPZL3 negatively regulates murine and human hair follicle cycling

April 2023 in “Journal of Investigative Dermatology”

A protein called MPZL3 in mitochondria slows down hair growth and could be a target for treating hair growth disorders.

research 1434 Epithelially derived MPZL3 negatively regulates murine and human sebaceous gland size and sebocyte proliferation

April 2023 in “Journal of Investigative Dermatology”

MPZL3 protein helps control the size of oil glands and the growth of oil-producing cells in both mice and humans.

Hunting the Hair Cycle Clock: Evidence That Mitochondrially Localized MPZL3 Is a Key Element in Murine and Human Hair Follicles

research 715 Hunting the hair cycle clock (HCC): Evidence that mitochondrially localized MPZL3 is a key HCC element in murine and human hair follicles

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

MPZL3 is important for controlling the hair growth cycle in mice and humans.

research 724 MPZL3 functions as a negative regulator of sebaceous gland size and sebocyte proliferation

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

MPZL3 protein helps keep sebaceous gland size and cell growth in check.

research Induction of osteoblastic differentiation of neural crest-derived stem cells from hair follicles

17 citations , April 2017 in “PLoS ONE”

Hair follicle cells can become bone-like cells, useful for bone repair.

research New developments in the molecular treatment of ichthyosis: review of the literature

21 citations , July 2022 in “Orphanet journal of rare diseases”

New treatments for ichthyosis, like protein replacement and gene therapy, show promise and may become standard care.

research Differential proteomics of lesional vs. non-lesional biopsies revealed non-immune mechanisms of alopecia areata

19 citations , January 2018 in “Scientific Reports”

Non-immune factors play a significant role in alopecia areata.

research The in vitro plasticity of hair follicle dermal and mesenchymal stem cells

January 2008 in “Durham e-Theses (Durham University)”

Hair follicle stem cells are similar to mesenchymal stem cells and can become neural-like cells under certain conditions.

research PKC downregulation upon rapamycin treatment attenuates mitochondrial disease

26 citations , December 2020 in “Nature metabolism”

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

research Alopecia in Association with Malignancy: A Review

26 citations , August 2018 in “American Journal of Clinical Dermatology”

Hair loss in cancer patients can be related to the cancer itself, treatment, or other conditions, and understanding it is important for diagnosis and patient care.

research CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance

11 citations , September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

A specific group of skin stem cells was found to help maintain hair follicle cells.

research 489 Seborrhea-like dermatitis phenotype in the Mpzl3 knockout mice

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

MPZL3 is crucial for seborrheic dermatitis development.

research Applications of Antioxidant Nanoparticles in Immune-Mediated Inflammatory Diseases

2 citations , September 2025 in “Antioxidants”

Antioxidant nanoparticles show promise for treating inflammatory diseases but need more research for safe and effective use.

Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites

research Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites

18 citations , March 2020 in “Frontiers in Neuroendocrinology”

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

research Adam10 haploinsufficiency causes freckle-like macules in Hairless mice

13 citations , July 2012 in “Pigment Cell & Melanoma Research”

A mutation in the Adam10 gene causes freckle-like spots on Hairless mice.

research Regeneration of skin appendages and nerves: current status and further challenges

71 citations , February 2020 in “Journal of Translational Medicine”

Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.

research Autophagy Dysfunction: The Kernel of Hair Loss?

May 2024 in “Clinical Cosmetic and Investigational Dermatology”

Manipulating cell cleanup processes could help treat hair loss.

research CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties

41 citations , April 2019 in “PLOS genetics”

CD34+ and CD34- melanocyte stem cells have different regenerative abilities.

research Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

6 citations , February 2023 in “Biomaterials Research”

Special gels help heal diabetic foot sores and reduce the risk of amputation or death.

research Advances in Nanotechnology Research in Food Production, Nutrition, and Health

5 citations , July 2025 in “Nutrients”

Nanotechnology can improve food safety, nutrition, and health, but safety and regulation challenges need addressing.

research A regenerative stem cell-derived matrix accelerates functional dermal wound repair in a preclinical diabetic model

February 2026

A stem cell-derived matrix speeds up healing of diabetic skin wounds.

Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation

research Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma

61 citations , April 2014 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

The Role of Immature and Mature Adipocytes in Hair Cycling

research Generating detailed intercellular communication patterns in psoriasis at the single-cell level using social networking, pattern recognition, and manifold learning methods to optimize treatment strategies

January 2024 in “Aging”

New insights into cell communication in psoriasis suggest innovative drug treatments.