research Comparative gene expression analysis of nestin-expressing hair follicle-derived cells
Nestin-expressing hair follicle cells may be useful for nerve repair and regeneration.
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research Rizatriptan benzoate-loaded dissolving microneedle patch for management of acute migraine therapy
Rizatriptan benzoate-loaded dissolving microneedles are effective and convenient for treating acute migraines.
research Exploration of Potential Secondary Plant Metabolites for the Treatment of Alopecia Areata
Secondary plant metabolites may offer a safer treatment for alopecia areata.
research Exploring the new horizons of drug repurposing: A vital tool for turning hard work into smart work
research Multiple sclerosis disease-modifying therapies: adverse effect surveillance and management
The document concludes that managing side effects of MS therapies is crucial for treatment success and patient adherence.
![Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1](/images/research/ff6e6cbe-cb9c-4d11-87ef-671d28ffd4fa/small/15506.jpg)
research Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1
Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.
research Neuroendocrine Controls of Keratin Expression in Human Skin
Neurohormones help control skin health and could treat skin disorders.
research Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn
Delta opioid receptors help regulate touch sensation by reducing neurotransmitter release in the spinal cord.
research Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids
New steroid derivatives show promise as anticancer agents, even against resistant cells.
research In vivo skin leptin modulation after 14 MeV neutron irradiation: a molecular and FT-IR spectroscopic study
research Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists
Formyl-peptide receptor agonists could be new anti-inflammatory drugs.
research Contemporary drug synthesis
The document summarized how various modern drugs are made.
research Recent Progress and Morphological Distribution of Polydopamine-Based Biomaterials and Their Applications
Polydopamine is promising for personalized medicine and biomedical technology due to its strong adhesion and biocompatibility.
research Modulating Aging and Aging-related Symptoms Using Endogenous Small Molecules
A molecule called α-ketobutyrate was found to extend lifespan and improve aging-related symptoms in worms and mice by activating certain cellular pathways and may help develop anti-aging treatments for humans.
research Psychoactive Agents in Dermatology
Psychoactive drugs can help treat skin conditions linked to psychological issues.
research A role of melatonin in neuroectodermal‐mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors
Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.
research Synthesis of novel andostane-N-cyclohexyl-17-carboxamides, and their effect on the 5α-reductase isoform 2, the androgen receptor, and androgen-dependent glands
New compounds were made and tested, with compound 6 showing potential for treating prostate-related diseases.
research Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure–Activity Relationship
Certain alkaloids could help create new coronavirus drugs.
research Untargeted metabolomics analysis of plasma metabolic characteristics in patients with acne and insulin resistance
Patients with acne and insulin resistance have different blood metabolites compared to those with only acne, which could help in diagnosis and treatment.
research Biochemical approach on the conservation of drug molecules during hair fiber formation
Drugs can be incorporated into hair based on their chemical properties and hair pigmentation.
research Pubertal hormones increase hippocampal expression of α4βδ GABAA receptors
Hormones during puberty increase certain receptors in the brain, and this change is influenced by estrogen levels.
research Drug-associated insomnia: A pharmacovigilance study based on FDA adverse event reporting system
Certain medications, especially nervous system drugs, can cause insomnia, with risks varying by age and gender.
research Analysis of androgen receptor expression and activity in the mouse brain
Androgen receptors in the mouse brain may explain cognitive and mood changes in prostate cancer treatment.
research Regulation of itch-induced scratching by nucleus accumbens dopamine receptor-expressing neurons
Dopamine receptors in the brain influence itch-related scratching behavior.
research Activity of steroid 4 and derivatives 4a–4f as inhibitors of the enzyme 5α-reductase 1
Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.
research Progesterone Promotes the Survival of Newborn Neurons in the Dentate Gyrus of Adult Male Mice
Progesterone helps adult male mice's brain cells survive and improves learning and memory.
research Ανάπτυξη καινοτόμων πεπτιδικών φορέων με ιδιότητες αυτοσυναρμογής για τοπική χορήγηση φαρμάκων
Self-assembling peptide hydrogels effectively deliver drugs locally, enhancing treatment and reducing side effects.
research Four Closure
Certain astrocytes can protect the brain and improve recovery after a stroke, and a hair loss drug might reduce cancer spread.
research GC-TOF/MS-Based Metabolomics for Comparison of Volar and Non-Volar Skin Types
Different types of skin on mice have unique chemical profiles related to how they grow and react to stress.
research Experimental Assessment of 3-meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-α-Reductase Inhibitors in silico and in vivo Models
The new compound is a promising, less toxic alternative to finasteride for treating prostate issues.