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Did you mean Next-Generation Sequencing?

GlossaryNext-Generation Sequencing

modern DNA sequencing technology that processes millions of fragments simultaneously

Next-Generation Sequencing (NGS) is a modern DNA sequencing technology that allows for the rapid sequencing of large stretches of DNA or entire genomes. Unlike traditional methods, NGS can process millions of DNA fragments simultaneously, making it a powerful tool for genetic research, including studying genetic causes of diseases like alopecia.

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research Next-generation Sequencing Identified a Novel EDA Mutation in a Chinese Pedigree of Hypohidrotic Ectodermal Dysplasia with Hyperplasia of the Sebaceous Glands

4 citations , January 2017 in “Acta dermato-venereologica”

A new EDA gene mutation was found in a Chinese family with a specific skin disorder.

research Investigation of Transcriptional Gene Profiling in Normal Murine Hair Follicular Substructures Using Next-Generation Sequencing to Provide Potential Insights into Skin Disease

1 citations , February 2016 in “Cell Transplantation”

Hair follicles have a more inactive cell cycle than other skin cells, which may help develop targeted therapies for skin diseases and cancer.

research Genotype–Phenotype Correlation in Children With Congenital Adrenal Hyperplasia due to 21‐Hydroxylase Deficiency Using Next Generation Sequencing

June 2025 in “Molecular Genetics & Genomic Medicine”

Severe genetic variants in children with a specific adrenal condition match predicted symptoms well, but milder variants do not.

research The post-terminal differentiation fate of RNAs revealed by next-generation sequencing

January 2012 in “eScholarship (California Digital Library)”

Hair and nails contain stable RNA, useful for personalized medicine and screening.

research Comprehensive analysis of circRNAs from cashmere goat skin by next generation RNA sequencing (RNA-seq)

39 citations , January 2020 in “Scientific Reports”

Four circRNAs were found to be significantly different in cashmere goat skin, affecting cashmere fineness.

research The Follicular Skin Microbiome in Patients With Hidradenitis Suppurativa and Healthy Controls

220 citations , May 2017 in “JAMA dermatology”

Patients with hidradenitis suppurativa have a different skin microbiome compared to healthy people.

research The Skin Microbiome: Current Landscape and Future Opportunities

114 citations , February 2023 in “International Journal of Molecular Sciences”

The skin microbiome is crucial for skin health, and more research is needed to explore its role and potential treatments.

research Transcriptional Characteristics Showed That miR-144-y/FOXO3 Participates in Embryonic Skin and Feather Follicle Development in Zhedong White Goose

46 citations , August 2022 in “Animals”

miR-144-y and FOXO3 play key roles in skin and feather development in Zhedong White geese.

research Unveiling the Roots of Monogenic Genodermatoses: Genotrichoses as a Paradigm

26 citations , December 2011 in “Journal of Investigative Dermatology”

New gene identification techniques have improved the understanding and classification of inherited hair disorders.

research Molecular Genetics of Keratinization Disorders – What’s New About Ichthyosis

18 citations , January 2020 in “Acta dermato-venereologica”

Over 67 genes linked to ichthyosis help improve diagnosis and treatment.

research Worldwide cohort study of 46, XY differences/disorders of sex development genetic diagnoses: geographic and ethnic differences in variants

13 citations , June 2024 in “Frontiers in Genetics”

About 50% of 46, XY DSD cases lack a genetic diagnosis, but advanced sequencing methods improve detection.

research Lamellar ichthyosis with pseudoexon activation in the transglutaminase 1 gene

10 citations , March 2015 in “Journal of dermatology”

The boy's severe skin disorder is caused by two new mutations in his TGM1 gene.

research A review of genotrichoses and hair pathology associated with inherited skin diseases

8 citations , March 2023 in “British Journal of Dermatology”

Next-generation sequencing greatly improves understanding and treatment of genetic hair disorders.

research Novel mutations of the ABCA12, KRT1 and ST14 genes in three unrelated newborns showing congenital ichthyosis

6 citations , August 2022 in “The Italian Journal of Pediatrics/Italian journal of pediatrics”

New genetic mutations linked to rare skin disorders were found in three newborns.

research Novel small‐insertion mutation in the LIPH gene in a patient with autosomal recessive woolly hair/hypotrichosis

1 citations , September 2020 in “Journal of dermatology”

Researchers found a new mutation in the LIPH gene of a woman with a rare hair condition.

research Who Am I? Eyebrow Follicles Minimize Donor-Derived DNA for Germline Testing After Hematopoietic Stem Cell Transplantation

January 2026 in “International Journal of Molecular Sciences”

Eyebrow follicles are best for accurate genetic testing after stem cell transplants.

research Precision therapeutics in non-scarring alopecia: a systemic genomic and pathway-based framework for targeted interventions

December 2025 in “ADMET & DMPK”

Personalized treatments for hair loss focus on specific genetic and biological pathways.

Wasabi Leaf Extract Changes the Expression Levels of Cytokine Related Genes in Dermal Papilla Cells, Identified by the Whole Transcriptome

research Wasabi leaf extract changes the expression levels of cytokine related genes in dermal papilla cells, which identified by the whole transcriptome

May 2025

Wasabi leaf extract affects gene expression in skin cells.

research Comprehensive transcriptome profiling between balding and non-balding scalp of female pattern hair loss in Asian

June 2024 in “Archives of Dermatological Research”

SFRP2 and PTGDS may be key factors in female hair loss.

research Comprehensive transcriptome profiling between balding and non-balding scalp of Female pattern hair loss in Asian

February 2024 in “Research Square (Research Square)”

The research suggests that SFRP2 and PTGDS proteins might be indicators of female pattern hair loss and could contribute to hair loss.

research Forensic DNA phenotyping: A promising tool to predict human appearance for forensic purposes

May 2023 in “Zenodo (CERN European Organization for Nuclear Research)”

Forensic DNA phenotyping can predict physical traits from DNA but faces challenges in knowledge and ethics.

research Forensic DNA phenotyping: A promising tool to predict human appearance for forensic purposes

May 2023 in “GSC biological and pharmaceutical sciences”

Forensic DNA phenotyping is becoming useful for predicting physical traits in criminal investigations but is limited by ethical concerns and incomplete genetic understanding.

research Inherited Epidermolysis Bullosa: A Clinical Case

January 2020 in “Medical journal of clinical trials & case studies”

A 37-year-old male with severe skin and internal issues has a rare inherited skin condition called dystrophic epidermolysis bullosa.

research Mixing the Old with the New: Drug Repurposing for Immune Deficiency in the Era of Precision Medicine and Pediatric Genomics

November 2018 in “The Journal of Allergy and Clinical Immunology: In Practice”

Using old drugs for new uses can help treat rare immune deficiencies.

research Perspectives of Alopecia behind the Regulation of Foxn1 Gene Exposes the Human Nude Phenotype

October 2018 in “InTech eBooks”

The gene Foxn1 is important for hair growth, and understanding it may lead to new alopecia treatments.

research 644 Tumor cell adhesion as a risk factor for SLN metastasis and predictor of disease recurrence in primary cutaneous melanoma

April 2016 in “Journal of Investigative Dermatology”

Tumor cell adhesion is linked to higher risk of SLN metastasis and melanoma recurrence, and a model including these factors predicts these outcomes better than one with just clinical data.

research Transcriptome Analysis Methods: From the Serial Analysis of Gene Expression and Microarray to Sequencing new Generation Methods

2 citations , December 2023 in “Biointerface Research in Applied Chemistry”

RNA-Seq is now the standard for detailed gene expression analysis.

The Role and Importance of Next-Generation Sequencing Technologies in Forensic Applications

research Adli Uygulamalarda Yeni Nesil Dizileme Teknolojilerinin Yeri ve Önemi

December 2024 in “Turkish Journal of Forensic Medicine”

Next-Generation Sequencing improves forensic analysis by providing detailed genetic information quickly.

research De NovoTranscriptome Assembly and Differential Gene Expression Profiling of ThreeCapra hircusSkin Types during Anagen of the Hair Growth Cycle

12 citations , January 2013 in “International Journal of Genomics”

The study identified key genes involved in goat hair growth.

research 1387 Identifying the key niche signals for hair follicle formation

April 2018 in “Journal of Investigative Dermatology”

Key signals for hair follicle formation were identified.