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Did you mean Next-Generation Sequencing?

GlossaryNext-Generation Sequencing

modern DNA sequencing technology that processes millions of fragments simultaneously

Next-Generation Sequencing (NGS) is a modern DNA sequencing technology that allows for the rapid sequencing of large stretches of DNA or entire genomes. Unlike traditional methods, NGS can process millions of DNA fragments simultaneously, making it a powerful tool for genetic research, including studying genetic causes of diseases like alopecia.

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research 644 Tumor cell adhesion as a risk factor for SLN metastasis and predictor of disease recurrence in primary cutaneous melanoma

April 2016 in “Journal of Investigative Dermatology”

Tumor cell adhesion is linked to higher risk of SLN metastasis and melanoma recurrence, and a model including these factors predicts these outcomes better than one with just clinical data.

The Role and Importance of Next-Generation Sequencing Technologies in Forensic Applications

research Adli Uygulamalarda Yeni Nesil Dizileme Teknolojilerinin Yeri ve Önemi

December 2024 in “Turkish Journal of Forensic Medicine”

Next-Generation Sequencing improves forensic analysis by providing detailed genetic information quickly.

research Novel Insights to Assess Climate Resilience in Goats Using a Holistic Approach of Skin-Based Advanced NGS Technologies

June 2023 in “International journal of molecular sciences”

Heat stress changes goats' skin and hair at the microscopic level and affects their genes and skin bacteria.

research Whole-genome bisulfite sequencing of goat skins identifies signatures associated with hair cycling

28 citations , August 2018 in “BMC genomics”

DNA methylation changes are linked to hair growth cycles in goats.

Transcriptome Sequencing Reveals Key Genes Associated With Hair Follicle Development in Qianhua Mutton Merino

research Transcriptome sequencing reveals the key genes associated with hair follicle development in Qianhua Mutton Merino

December 2025 in “Frontiers in Veterinary Science”

Key genes like KRT27 and IGF-2 are crucial for hair follicle development in Qianhua Mutton Merino sheep.

research A partially automated method for DNA extraction from marmoset hair follicles to avoid blood chimerism

September 2025 in “Frontiers in Genetics”

The method effectively extracts high-quality DNA from marmoset hair, avoiding blood chimerism.

research De novo single-nucleotide and copy number variation in discordant monozygotic twins reveals disease-related genes

36 citations , March 2019 in “European Journal of Human Genetics”

The research found genetic differences in identical twins that could explain why one twin has a disease while the other does not.

The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells

research The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells

35 citations , July 2018 in “Cell Reports”

The study found that a specific area of the hair follicle helps start hair growth by reducing the blocking effects on certain cells and controlling growth signals.

research The inconsistent regulation of HOXC13 on different keratins and the regulation mechanism on HOXC13 in cashmere goat (Capra hircus)

17 citations , August 2018 in “BMC Genomics”

The HOXC13 gene affects different hair proteins in cashmere goats in varied ways and is controlled by a feedback loop and other factors.

research News in brief

June 2011 in “Expert Review of Dermatology”

Researchers discovered potential origins and new treatments for skin cancer, including biomarkers for melanoma and therapies that reduce tumor growth.

research Comparative study on seasonal hair follicle cycling by analysis of the transcriptomes from cashmere and milk goats

25 citations , February 2019 in “Genomics”

Cashmere and milk goats have different hair growth cycles and gene expressions, which could help improve wool production.

research Synchronous profiling and analysis of mRNAs and ncRNAs in the dermal papilla cells from cashmere goats

17 citations , June 2019 in “BMC genomics”

Non-coding RNAs help control hair growth in cashmere goats.

research Wound healing mechanism in Mongolian gerbil skin

6 citations , November 2018 in “Histochemistry and Cell Biology”

Mongolian gerbils heal wounds differently than mice, with unique protein levels and gene expression that affect skin repair.

research Molecular Regulation and Cellular Heterogeneity in Skin Repair and Hair Follicle Regeneration

January 2019

Ovol2 is crucial for hair growth and skin healing by controlling cell movement and growth.

research EMQN best practice guidelines for molecular genetic testing and reporting of 21-hydroxylase deficiency

94 citations , July 2020 in “European Journal of Human Genetics”

The guidelines ensure accurate genetic testing and reporting for 21-hydroxylase deficiency.

research Investigating the potential mechanism of microneedling in alopecia areata mice based on 16S rRNA sequencing and metabolomics

August 2025 in “Frontiers in Microbiology”

Microneedling, especially with halometasone, improves hair regrowth and gut health in alopecia areata.

research Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris

194 citations , October 2018 in “Microbiome”

Acne is linked to complex skin microbe interactions, and new findings suggest microbiome-based treatments could be effective.

research Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats

2 citations , July 2025 in “Frontiers in Veterinary Science”

MicroRNAs and AI can improve cashmere goat hair quality and aid in hair disorder diagnosis.

research Therapeutic small extracellular vesicles from key human stem and immune cellular sources: A review

January 2026 in “Journal of Biomedical Research”

Small extracellular vesicles from stem and immune cells show promise for treating various diseases but face challenges in clinical use.

research Abstracts

2 citations , January 2019 in “Medizinische Genetik”

The document reports findings on genetic research, including ethical concerns about genome editing, improved diagnosis of mitochondrial mutations, solving inherited eye diseases, confirming gene roles in epilepsy, linking a gene to aneurysms, and identifying genes associated with age-related macular degeneration.

research Gene Expression in Rat Dermal Papilla Cells: Analysis of 2529 ESTs

14 citations , October 2000 in “Genomics”

Rat dermal papilla cells have unique genes crucial for hair growth.

research Chi-miR-30b-5p inhibits dermal papilla cells proliferation by targeting CaMKIIδ gene in cashmere goat

13 citations , June 2020 in “BMC genomics”

A specific microRNA, chi-miR-30b-5p, slows down the growth of hair-related cells by affecting the CaMKIIδ gene in cashmere goats.

research Quantitative Single-Cell Approaches to Stem Cell Research

106 citations , November 2014 in “Cell Stem Cell”

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

research Transcriptome profiling of whisker follicles in methamphetamine self-administered rats

6 citations , July 2018 in “Scientific Reports”

Methamphetamine affects gene expression in rat whisker follicles, with key genes linked to addiction.

research PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection

4 citations , May 2025 in “npj Parkinson s Disease”

PINK1 is important for controlling gut immune responses linked to early Parkinson's disease.

research Innervated Biomaterials for Improved Cutaneous Wound Healing: A Review of Recent Advancements and Future Prospects

2 citations , June 2025 in “International Journal of Nanomedicine”

New biomaterials can improve wound healing by promoting nerve and tissue regeneration.