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Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation

45 citations , March 2020 in “International Journal of Nanomedicine”

Clove essential oil nanoemulgel effectively reduces skin inflammation and is a promising alternative to traditional anti-inflammatory drugs.

research Lysophosphatidic acid and signaling in sensory neurons

20 citations , January 2015 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

Lysophosphatidic acid affects sensory neurons and may cause neuropathic pain and itch.

research Spatiotemporal regulation of acute wound healing by the NLRP3 inflammasome: dual roles in macrophage-fibroblast chemotaxis and phenotype during wound repair

January 2026 in “Burns & Trauma”

NLRP3 helps control inflammation and repair in wound healing, making it a potential target for treatment.

research Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson’s Disease

9 citations , December 2023 in “Journal of Neuroimmune Pharmacology”

NDP-MSH protects brain cells and reduces inflammation in Parkinson's disease by activating MC1R and involving Tregs.

research 442 Deciphering the role of keloid fibroblasts in itch

November 2025 in “Journal of Investigative Dermatology”

Keloid fibroblasts cause itch and pain by releasing more histamine.

research The Pathological Culprit of Neuropathic Skin Pain in Long COVID-19 Patients: A Case Series

5 citations , July 2022 in “Journal of Clinical Medicine”

Long COVID-19 patients with skin pain might have a nerve condition that responds to a medication called gabapentin.

Targeting Anti-Inflammatory Immunonanocarriers to Human and Murine Neutrophils via Ly6 Antigen for Psoriasiform Dermatitis Alleviation

research 1113 Targeting anti-inflammatory immunonanocarriers to human and murine neutrophils via Ly6 antigen for psoriasiform dermatitis alleviation

April 2023 in “Journal of Investigative Dermatology”

The study created special nanoparticles that effectively deliver an anti-inflammatory drug to treat skin inflammation in psoriasis.

research 50285 Oxytocin receptor is present in keratinocytes near touch and pain sensory neurons

September 2024 in “Journal of the American Academy of Dermatology”

Oxytocin receptors are found in skin cells near touch and pain neurons.

TNC+ Fibroblasts Involved in Skin Inflammation via Neuro-Immune Interactions with T Cells

research TNC+ fibroblasts involve in skin inflammation via neuro-immune and interacting with T cells

September 2023 in “Research Square (Research Square)”

TNC+ fibroblasts play a key role in skin inflammation by interacting with T cells.

research Inflammatory memory-activated biomimetic nanovesicles regulate neutrophil plasticity and metabolic reprogramming for rapid diabetic wound healing via targeting miR-193a-5p/TLR4/JNK/P38 MAPK pathways

9 citations , February 2025 in “Journal of Nanobiotechnology”

Biomimetic nanovesicles can speed up diabetic wound healing by regulating immune cell behavior and metabolism.

Advancements in Research on the Immune-Inflammatory Mechanisms Mediated by NLRP3 Inflammasome in Ischemic Stroke and the Regulatory Role of Natural Plant Products

research Advancements in research on the immune-inflammatory mechanisms mediated by NLRP3 inflammasome in ischemic stroke and the regulatory role of natural plant products

18 citations , March 2024 in “Frontiers in Pharmacology”

Natural plant products like Proanthocyanidins and curcumin may help treat ischemic stroke by reducing inflammation.

research Nucleic acid-induced chemokine expression in keratinocytes: Implications for skin inflammation

November 2025 in “PLoS ONE”

Nucleic acids trigger chemokine production in skin cells, affecting skin inflammation.

research Pain in Multiple Sclerosis: Understanding Pathophysiology, Diagnosis, and Management Through Clinical Vignettes

35 citations , January 2022 in “Frontiers in Neurology”

Effective pain management in multiple sclerosis requires individualized treatment strategies.

research Localization of mechanosensitive channel TRPV4 in mouse skin

123 citations , November 2003 in “Neuroscience Letters”

TRPV4 helps sense pressure in mouse skin.

research 438 Laminin-511 is a new player in the development of psoriasis and controlled via cannabinoid receptor type 1

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

Laminin-511 is involved in psoriasis development and can be regulated by cannabinoid receptor type 1.

research Human dermal fibroblast‐derived secretory proteins for regulating nerve restoration: A bioinformatic approach

1 citations , June 2024 in “Skin Research and Technology”

Human dermal fibroblast proteins help restore nerves during healing.

research Stress exposure modulates peptidergic innervation and degranulates mast cells in murine skin

115 citations , November 2004 in “Brain Behavior and Immunity”

Stress increases nerve fibers and immune cell activity in mouse skin, possibly worsening skin conditions.

research Regenerative Medicine

3 citations , October 2020 in “IntechOpen eBooks”

Regenerative medicine may offer long-lasting relief for chronic pain and neuro-degenerative conditions.

research Effects of transient receptor potential (TRP) channel agonists and antagonists on slowly adapting type II mechanoreceptors in the rat sinus hair follicle

13 citations , December 2009 in “Journal of the Peripheral Nervous System”

TRPA1 and TRPV1 channels don't affect mechanotransduction in rat sinus hair follicles.

Role of Extracellular Nucleic Acids in Regeneration Processes

research Роль внеклеточных нуклеиновых кислот в процессах регенерации

July 2023 in “Письма в Вавиловский журнал генетики и селекции”

Extracellular nucleic acids help start inflammation needed for tissue repair, but must be properly regulated.

research Synaptic‐like vesicles and candidate transduction channels in mechanosensory terminals

11 citations , July 2015 in “Journal of Anatomy”

SLVs help maintain muscle stretch sensitivity and could aid in treating hypertension and muscle spasticity.

research Nitric Oxide Signal Transduction and Its Role in Skin Sensitization

1 citations , June 2023 in “Biomolecules & therapeutics”

Nitric oxide is important for skin functions and both helps protect against and contributes to skin inflammation and sensitization.

research Single cell deciphering of pruritic keloids: the interaction between fibroblasts and Schwann cells through the Midkine signaling

1 citations , January 2025 in “Burns & Trauma”

Targeting Midkine can help reduce pain and itching in keloids.

Impeding Glial Scarring Hyperplasia and Activating Axon Neogenesis via Immunomodulatory Microneedle Patch for Spinal Cord Repair

research Impeding Glial Scarring Hyperplasia and Activating Axon Neogenesis via Immunomodulatory Microneedle Patch for Spinal Cord Repair

November 2025

A new microneedle patch helps repair spinal cord injuries by reducing scarring and promoting nerve growth.

research 647 NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing caspase-3 activity in human melanoma

1 citations , April 2016 in “Journal of Investigative Dermatology”

NLRP1 helps melanoma tumors grow by boosting inflammasome activation and reducing caspase-3 activity.

Neuronal Plasticity of the Brain-Skin Connection: Stress-Triggered Up-Regulation of Neuropeptides in Dorsal Root Ganglia and Skin via Nerve Growth Factor-Dependent Pathways

research Neuronal plasticity of the “brain–skin connection”: stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways

66 citations , July 2007 in “Journal of Molecular Medicine”

Stress increases certain chemicals in the skin and nerves, which might worsen skin conditions.

research Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition

3 citations , October 2021 in “PLoS ONE”

Piperonylic acid speeds up wound healing by reducing inflammation and boosting collagen.

research Finasteride, a 5alpha-reductase inhibitor, potentiates antinociceptive effects of morphine, prevents the development of morphine tolerance and attenuates abstinence behavior in the rat

4 citations , April 2009 in “Journal of Pain”

Finasteride boosts morphine's pain relief and prevents tolerance and withdrawal in rats.

research Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR.

122 citations , June 1998 in “PubMed”

Neurotrophins regulate nerve growth by balancing promotion and suppression.

research The Role of Other Peripheral Nerve Blocks

January 2019 in “Headache”

Peripheral nerve blocks are a safe and effective way to treat various headaches and provide lasting pain relief.

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