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Disruption of glycinergic circuits increases pain sensitivity, suggesting new pain treatment options.

Lysophosphatidic acid affects sensory neurons and may cause neuropathic pain and itch.

The symposium highlighted the skin's role in sensing itch, pain, touch, and pleasure, and discussed new research and techniques for understanding and treating these sensations.

Dopamine receptors in the brain influence itch-related scratching behavior.

Naked mole-rats have unique skin and hair nerve structures, lacking certain pain and temperature-related neuropeptides.

Scientists found a specific group of itch-sensing nerve cells in mice important for feeling itch but not for sensing heat or touch.

The transcription factor Meis2 is essential for touch sensation and proper nerve development in touch receptors.

A new imaging method helps see and study touch nerve endings in mouse skin.

A special receptor in sensory nerve endings helps control how they respond to stretching.

Keloid fibroblasts cause itch and pain by releasing more histamine.

Microstimulation of certain facial and mouth nerves can evoke specific sensations, while deeper nerves may require multiple stimulations to affect perception.

A compound named ZCZ90 can increase muscle spindle firing, potentially helping treat muscle spasms and hypertension.

New therapies targeting skin neuroimmune interactions could treat neuropathic pain.

Long COVID-19 patients with skin pain might have a nerve condition that responds to a medication called gabapentin.

Different hair follicles in the skin are innervated by unique combinations of mechanosensory neurons, crucial for touch sensation.

Increasing neurotrophin 4 in skin boosts nerve endings but not sensory neuron count.

A new pain-measuring system using sensors and AI can effectively detect pain in mice, which may help assess pain in humans and develop treatments.

Hairy skin feels prickling more intensely than smooth skin.

Club-like receptors detect light touch but not whisking.

Methylene blue staining effectively reveals detailed nerve structures in rat snouts.

Meis2 is essential for touch sensation and nerve function in mice.

Methylene blue staining effectively highlights detailed nerve structures in rat fur.

TRPA1 and TRPV1 channels don't affect mechanotransduction in rat sinus hair follicles.

Improving nerve and immune interactions may help heal chronic wounds.

Touching hair can activate nearby nerve cells through signals from the hair's outer layer.

TRPV3 in skin cells causes inflammation and cell death.

Meis2 is essential for touch sensation and proper nerve connection to touch receptors in certain skin areas of mice.

The TRPV3 channel structure changes linked to severe itch and hyperkeratosis were identified using cryo-EM.

KCNQ potassium channels help control the sensitivity of touch receptors in the skin.