research Hirsutism in a Female Adolescent Induced by Long-Acting Injectable Risperidone
A teenage girl's excessive hair growth was caused by a medication for mania, but improved after stopping the medication.
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research Chronic Exposure with 5‐Alpha Reductase Inhibitor Ameliorates Anxiety and Depression‐like Behaviors By Reducing Systemic Oxidative Stress in D‐galactose‐Induced Aging Male Rats
Finasteride may help reduce anxiety and depression in elderly but might cause depression in young men.
research The neurosteroid metabolite of progesterone, 3α‐OH‐dihydroprogesterone (3α‐OH‐DHP), is required for attenuated baroreflex mediated sympathoexcitation in pregnancy
3α‐OH‐DHP is essential for reducing nerve activity related to blood pressure control during pregnancy.
research Cyproterone Acetate in the Treatment of Sexual Disorders: Pharmacological Base and Clinical Experience
Cyproterone acetate effectively treats sexual disorders by reducing sexual functions and is generally well-tolerated.
research Finasteride as a model for personalized medicine
Finasteride treatment should be personalized to individual mental profiles.
research Abstract ED05-04: Presurgical models to effectively screen preventive agents
Presurgical models can effectively and affordably screen cancer prevention agents.
research Can we teach old drugs new tricks?—Repurposing of neuropharmacological drugs for inflammatory skin diseases
Old neuropharmacological drugs might be effective for treating inflammatory skin diseases.
research Trichotillomania Across Circuits: Neurobiology, Sensory Processing, and Genetic Insights
Trichotillomania treatment is improving with behavior therapy and new drug approaches, but challenges like stigma and underdiagnosis remain.
research The effect of St John's Wort on the pharmacokinetics and metabolism of finasteride in healthy men
research Flurandrenolide
research Recent Progress in Prostaglandin F2αEthanolamide (Prostamide F2α) Research and Therapeutics
New research on prostamide F2α has led to treatments for glaucoma and eyelash growth and may have more medical uses.
research Effect of Neurosteroid Withdrawal on Spontaneous Recurrent Seizures in a Rat Model of Catamenial Epilepsy
Neurosteroid withdrawal increases seizure frequency in a rat model of catamenial epilepsy.
research Anti-Androgen Treatment of Hirsute Women: A Study on Stress Responses
The treatment reduced hair growth and testosterone in women with excess hair and had some effects on stress responses.
research Involvement of neurosteroids in the control of prolactin secretion in sheep under basal, stressful and pregnancy conditions
Neurosteroids affect prolactin levels in sheep differently depending on stress and pregnancy conditions.
research Drug Information Analysis Service
Cromolyn sodium's effectiveness for treating asthma in children under 2 is unclear, possibly more beneficial for older children, and further research is needed.
research Progesterone regulates corticosterone elevation and alterations in spatial memory and exploratory behavior induced by stress in Wistar rats
Progesterone helps protect against stress-related memory and behavior issues in rats.
research Prednisolone
A woman's hair grew back after she stopped taking the Parkinson's disease medication pramipexole.
research 3α-androstanediol, but not testosterone, attenuates age-related decrements in cognitive, anxiety, and depressive behavior of male rats
3α-androstanediol helps reduce age-related cognitive and mood declines in male rats, unlike testosterone.
research Hormonal manipulation of benign prostatic hyperplasia
Finasteride and dutasteride are equally effective and safe for treating benign prostatic hyperplasia.
research The nocebo effect: A clinicians guide
Negative expectations can cause adverse effects in patients even without active treatment, and managing this nocebo effect involves better communication and patient-clinician relationships.
research Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice
Finasteride reduces new brain cells in male mice, possibly causing depression.
research Latest advances in oral hormonal male contraception: efficacy, mechanisms of action, and future perspectives
New male contraceptive pills show promise in reducing sperm production with mild side effects.
research Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production
A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.
research Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers?
New compounds similar to cromakalim were less effective at inhibiting insulin release but improved in solubility and one acted as a calcium entry blocker, not a potassium channel opener.
research Effects of Nitrendipine (BAY e 5009), Nifedipine, Verapamil, Phentolamine, Papaverine, and Minoxidil on Contractions of Isolated Rabbit Aortic Smooth Muscle
Nitrendipine and nifedipine effectively block muscle contractions, while papaverine relaxes them and minoxidil needs high amounts to work.
research Neonatal allopregnanolone or finasteride administration modifies hippocampal K+ Cl− co-transporter expression during early development in male rats
Allopregnanolone increases KCC2 expression in baby male rats' brains, while finasteride doesn't affect it.
research Impaired Cardiometabolic Effects of Bromocriptine in Men With Early‐Onset Androgenic Alopecia
Men with early-onset hair loss have less cardiometabolic benefit from bromocriptine.
research Synthesis and Pharmacological Evaluation of New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors
Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.
research A Mouse Kindling Model of Perimenstrual Catamenial Epilepsy
Neurosteroids help reduce seizures, but their withdrawal increases seizure activity.
research Anti-Androgen Drugs in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review
Anti-androgen drugs can help reduce OCD symptoms, but more large-scale trials are needed to confirm their effectiveness.