research Novel synthesis of nicotinamide derivatives of cytotoxic properties
Newly made nicotinamide compounds could potentially treat cancer.
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research Niosomes: A Novel Targeted Drug Delivery System
Niosomes are a promising method for delivering drugs directly to targeted areas in the body.
research Inhibition of 5α‐Reduced Steroid Biosynthesis Impedes Acquisition of Ethanol Drinking in Male C57BL/6J Mice
Finasteride reduces alcohol consumption in mice by affecting brain chemicals.
research 461: THE PROFIBROGENIC ROLE OF NEUTROPHIL EXTRACELLULAR TRAPS IN STENOTIC CROHN'S DISEASE: A NEW ANTIFIBROTIC TARGET?
Targeting NETs may help reduce fibrosis in Crohn's disease.
research Selective isomerization of α-pinene oxide to campholenic aldehyde by ionic liquid-supported indenyl-molybdenum(II)-bipyridine complexes
The process efficiently converts α-pinene oxide to campholenic aldehyde using a special catalyst, achieving high yields quickly.
research Isolation and identification of endophytic actinobacteria from Citrullus colocynthis (L.) Schrad and their antibacterial properties
Certain bacteria from the Citrullus colocynthis plant may be a new source of antibiotics to fight drug-resistant diseases.
research Olorofim Effectively Eradicates Dermatophytes In Vitro and In Vivo
Olorofim effectively treats fungal skin infections.
research Functionalization of Alkenes with Difluoromethyl Nitrile Oxide to Access the Difluoromethylated Derivatives
A new method efficiently modifies alkenes to create useful medicinal compounds.
research Folate-cyclodextrin Conjugate for Targeted Chemotherapy
The folate-cyclodextrin conjugate targets cancer cells more precisely, potentially reducing chemotherapy side effects.
research Off-label prescriptions: patient safety first
Off-label drug use can be risky and requires careful consideration to ensure patient safety.
research Tunable Structured Metal Oxides for Biocatalytic Therapeutics
Tunable structured metal oxides show promise for various medical treatments due to their versatility and cost-effectiveness.
research 5-Alpha Reductase Inhibitors in Prostate Cancer: From Clinical Trials to Clinical Practice
5-Alpha reductase inhibitors may prevent prostate cancer but are not widely used due to concerns about trial relevance and potential risks, and more research is needed to confirm long-term benefits.
research Pathogenetic justification of the use of 5-alpha reductase inhibitors in the treatment of benign prostatic hyperplasia.
5-alpha reductase inhibitors help with benign prostatic hyperplasia but don't cure it, and more research is needed.
research New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors.
Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.
research 603 Degradation of aberrant NETs by DNases is a promising therapeutic strategy for SJS/TEN
Using DNase enzymes to break down harmful NETs could be a new treatment for Stevens-Johnson syndrome and toxic epidermal necrolysis.
research Evaluation of risk of SSRI-associated impotence and low libido in men exposed to finasteride
Finasteride and SSRIs together increase impotence and low libido risk in men.
research Harmonic Vibrational Frequency Simulation of Pharmaceutical Molecules via a Novel Multi-Molecular Fragment Interception Method
The new method provides more accurate vibrational frequencies for drug molecules than traditional models.
research Machine learning for nanozyme development in anti‐inflammatory applications
Rational design strategies are crucial for developing effective nanozymes for anti-inflammatory uses.
research An exploratory analysis of 5‐alpha reductase inhibitors and risk of opioid use disorder among male Medicare beneficiaries receiving prescription opioid medications
Using 5-alpha reductase inhibitors may lower the risk of opioid addiction in men taking opioids.
research Formulation of pH-responsive PEGylated nanoparticles with high drug loading capacity and programmable drug release for enhanced antibacterial activity
The nanoparticles effectively deliver antibiotics to fight resistant bacteria.
research Abstract A12: Androgen receptor inhibition is involved in Finasteride-reduced AML cell proliferation
Finasteride reduces AML cell growth by inhibiting androgen receptors.
research Synchronous fluorescence as a green and selective method for the simultaneous determination of finasteride and tadalafil in dosage form and spiked human plasma
A new green method accurately measures finasteride and tadalafil in drugs and plasma.
research Finasteride toxicity information: “limited”, “poor quality”, “biased”
Finasteride toxicity information is limited, poor quality, and biased.
research Niosomes as Efficient Nanocarriers for Targeted Drug Delivery
Niosomes are effective carriers for targeted drug delivery, improving drug stability and efficiency.
research A review on computer‐aided chemogenomics and drug repositioning for rationalCOVID‐19 drug discovery
Computer-aided methods can speed up COVID-19 drug discovery and help find new uses for existing drugs.
research Can nanozymes make the leap to the clinic? Advances, hurdles, and prospects
Nanozymes have potential for medical use but face challenges like safety and regulation.
research A new label-free screen for steroid 5α-reductase inhibitors using LC-MS
Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.
research Organizadores e cortadores de comprimidos: riscos e restrições ao uso
Pill organizers and cutters can help with taking medication regularly but may affect the medication's effectiveness and safety.
research PD49-02 MEDICATIONS MOST COMMONLY ASSOCIATED WITH ERECTILE DYSFUNCTION: EVALUATION OF THE FOOD AND DRUG ADMINISTRATION NATIONAL PHARMACOVIGILANCE DATABASE
Certain medications, especially 5-alpha reductase inhibitors, are commonly linked to erectile dysfunction.
research DIHYDROTESTOSTERONE AND THE PROSTATE: THE SCIENTIFIC RATIONALE FOR 5α-REDUCTASE INHIBITORS IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA
Drugs that block DHT production can effectively treat enlarged prostate and improve urinary issues with some sexual side effects.