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GlossaryEstrogenic Activity

ability of a substance to mimic or influence estrogen effects

Estrogenic activity refers to the ability of a substance to mimic or influence the effects of estrogen, a primary female sex hormone, in the body. This can impact various biological processes, including reproductive health, bone density, and hair growth. Substances with estrogenic activity can bind to estrogen receptors and trigger similar responses as natural estrogen, which is why they are significant in both medical treatments and environmental health studies.

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research Mechanism of action of bolandiol (19-nortestosterone-3β,17β-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities

11 citations , November 2009 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.

Combined Oral Contraceptives Promote Androgen Receptor And Estrogen Receptor Alpha Upregulation In The Female Prostate (Skene’s Paraurethral Glands) Of Adult Gerbils (Meriones Unguiculatus)

research Combined oral contraceptives promote androgen receptor and oestrogen receptor alpha upregulation in the female prostate (Skene’s paraurethral glands) of adult gerbils (Meriones unguiculatus)

3 citations , January 2018 in “Reproduction, Fertility and Development”

Birth control pills increase certain receptor activities in female gerbil prostate glands and can lead to prostate changes.

research Estrogenic Potential of 2-Alkyl-4-(thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

37 citations , September 2003 in “Journal of Medicinal Chemistry”

A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.

Hormonal Activity in Commonly Used Black Hair Care Products: Evaluating Hormone Disruption as a Plausible Contribution to Health Disparities

research Hormonal activity in commonly used Black hair care products: evaluating hormone disruption as a plausible contribution to health disparities

25 citations , May 2021 in “Journal of exposure science & environmental epidemiology/Journal of exposure science and environmental epidemiology”

Common Black hair care products may affect hormone levels and potentially impact health, especially in reproductive and metabolic areas.

research NFIC promotes the vitality and osteogenic differentiation of rat dental follicle cells

11 citations , August 2019 in “Journal of Molecular Histology”

NFIC helps rat dental cells grow and turn into bone-like cells.

research Osteogenic Potential of Mesenchymal Stem Cells from Adipose Tissue, Bone Marrow and Hair Follicle Outer Root Sheath in a 3D Crosslinked Gelatin-Based Hydrogel

2 citations , May 2021 in “International journal of molecular sciences”

Stem cells from hair follicles in a special gel show strong potential for bone regeneration.

research Optimal stimulation toward the dermal papilla lineage can be promoted by combined use of osteogenic and adipogenic inducers

2 citations , November 2019 in “FEBS open bio”

Combining specific inducers helps dermal papilla cells regain hair-forming ability.

research Comparative characterization and osteogenic / adipogenic differentiation of mesenchymal stem cells derived from male rat hair follicles and bone marrow

6 citations , August 2020 in “Cell regeneration”

Hair follicle stem cells are similar to bone marrow stem cells but are better for fat cell research.

Multiple Readout Assay for Hormonal (Androgenic and Antiandrogenic) and Cytotoxic Activity of Plant and Fungal Extracts Based on Differential Prostate Cancer Cell Line Behavior

research Multiple readout assay for hormonal (androgenic and antiandrogenic) and cytotoxic activity of plant and fungal extracts based on differential prostate cancer cell line behavior

19 citations , August 2014 in “Journal of Ethnopharmacology”

The study created a test that found hormonal and toxic effects in plant and fungal extracts using prostate cancer cells.

research N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase

17 citations , December 2004 in “Bioorganic & Medicinal Chemistry Letters”

Scientists found new, better-working inhibitors for a hormone-related enzyme.

Drug Delivery Applications of Three-Dimensional Printed Mesoporous Scaffolds

research Drug Delivery Applications of Three-Dimensional Printed (3DP) Mesoporous Scaffolds

28 citations , September 2020 in “Pharmaceutics”

3D-printed mesoporous scaffolds show promise for personalized drug delivery with controlled release.

research Final Report on the Safety Assessment of Human Placental Protein, Hydrolyzed Human Placental Protein, Human Placental Enzymes, Human Placental Lipids, Human Umbilical Extract, Placental Protein, Hydrolyzed Placental Protein, Placental Enzymes, Placental Lipids, and Umbilical Extract

13 citations , April 2002 in “International Journal of Toxicology”

The safety of placental and umbilical extracts in cosmetics is uncertain, requiring more research.

research Selective androgen receptor modulators: a critical appraisal

2 citations , September 2025 in “Frontiers in Endocrinology”

SARMs show promise but need more evidence to prove they're better than traditional androgens.

Clinical Aspects, Pathogenesis, and Therapy Options of Alopecia Induced by Hormonal Therapy for Breast Cancer

research Clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer

2 citations , October 2021 in “Exploration of targeted anti-tumor therapy”

Breast cancer hormone therapy can cause hair loss, which can be treated with daily applications of specific topical solutions like minoxidil and hydrocortisone butyrate.

research Could the use of personal care oils in black women contribute to recent findings of an increased risk of breast cancer in this population?

2 citations , May 2020 in “Journal of the American Academy of Dermatology”

Using certain hair products may increase breast cancer risk in black women.

research A Phytochemical and Pharmacological Review on Cynomorium songaricum as Functional and Medicinal Food

2 citations , April 2018 in “Natural Product Communications”

Cynomorium songaricum has many health benefits and could help with hair regrowth.

research Drugs and Androgenetic Alopecia: What to look out for

September 2024

Certain drugs can worsen hair loss in people prone to androgenetic alopecia.

research PSSD,PFS,PRSD: A perspective for aetiology and treatment

April 2023

The paper suggests that a decrease in estrogen receptor activity may cause sexual dysfunction syndromes and proposes hormonal treatments.

research Contaminants of emerging concern in the fetal environment

November 2022

Fetal environments contain various chemicals that may disrupt hormones.

research Low sex-hormone binding globulin levels in young women with diffuse hair loss

40 citations , March 1982 in “British Journal of Dermatology”

Young women with diffuse hair loss may have low SHBG levels, which could lead to more active testosterone and contribute to their hair loss.

research Roles of steroid receptors in the lung and COVID-19

9 citations , July 2021 in “Essays in Biochemistry”

Sex hormones may influence COVID-19 severity, with males at higher risk, and certain hormone therapies could potentially treat the virus.

research Dermal papilla cells induce keratinocyte tubulogenesis in culture Elina S. ChermnykhEkaterina A. VorotelyakKsenia Y. Gnedeva • Marianna V. MoldaverYegor E. YegorovAndrey V. Vasiliev •

January 2010

Dermal papilla cells can help form hair-like structures in lab-grown skin cells.

research Dermal papilla cells induce keratinocyte tubulogenesis in culture

28 citations , March 2010 in “Histochemistry and cell biology”

Skin cells can help create early hair-like structures in lab cultures.

research Lentiviral Arrays for Live-cell Dynamic Monitoring of Gene and Pathway Activity During Stem Cell Differentiation

13 citations , June 2014 in “Molecular therapy”

The lentiviral array can monitor and predict gene activity during stem cell differentiation.

research Effects of dihydrotestosterone on osteoblast activity in curdlan-administered SKG mice and osteoprogenitor cells in patients with ankylosing spondylitis

8 citations , May 2020 in “Arthritis research & therapy”

DHT inhibition may increase spinal bone growth in ankylosing spondylitis.

research TMT-Based Proteomic Explores the Influence of DHEA on the Osteogenic Differentiation of hBMSCs

5 citations , August 2021 in “Frontiers in Cell and Developmental Biology”

DHEA boosts bone cell growth and differentiation in elderly stem cells.

research Intracrinology and The Skin

82 citations , January 2000 in “Hormone Research in Paediatrics”

DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.

research [Androgenetic alopecia].

May 2002 in “PubMed”

Androgenetic alopecia, or hair loss, is caused by genetic factors and hormones, with different mechanisms in men and women, and can be linked to insulin resistance and polycystic ovary syndrome.

Sulphation Catalyzed by the Human Cytosolic Sulphotransferases: Chemical Defense or Molecular Terrorism?

research Sulphation catalysed by the human cytosolic sulphotransferases - chemical defence or molecular terrorism?

48 citations , July 1996 in “Human & Experimental Toxicology”

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

research Mitochondrial Oxygen Consumption and Immunocytochemistry of Human Dental Pulp Stem Cell Following 808 nm PBM Therapy: A 3D Cell Culture Study

April 2025 in “Journal of Biophotonics”

PBM therapy improves mitochondrial function and promotes tissue regeneration in dental pulp stem cells.