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GlossaryOncostatin M

cytokine involved in inflammation and cell growth regulation

Oncostatin M (OSM) is a cytokine, a type of protein involved in cell signaling, that plays a role in inflammation, immune responses, and the regulation of cell growth. It is part of the interleukin-6 (IL-6) family and can influence processes such as wound healing and the development of certain diseases, including cancer and autoimmune disorders.

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research A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth

101 citations , March 2019 in “Cell Stem Cell”

Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.

Hair Growth Induced by Blockade of Macrophage-Derived Oncostatin M and Downstream JAK-STAT5 Signaling in Hair Follicle Stem Cells

research 1359 Hair growth is induced by blockade of macrophage-derived oncostatin M and downstream JAK-STAT5 signaling in hair follicle stem cells

April 2018 in “Journal of Investigative Dermatology”

Blocking a specific immune cell signal can trigger hair growth.

research 700 Oncostatin M is upstream of JAK-STAT signaling during the murine hair cycle

April 2016 in “Journal of Investigative Dermatology”

Blocking Oncostatin M's role in the JAK-STAT pathway can stimulate hair growth in mice.

research Interleukin-6 Null Mice Paradoxically Display Increased STAT3 Activity and Wound-Induced Hair Neogenesis

16 citations , January 2016 in “Journal of Investigative Dermatology”

Mice without the IL-6 gene had more hair growth after injury due to higher activity of a related protein, Stat3.

research Causal relationship between inflammatory cytokines and polycystic ovary syndrome: a bidirectional mendelian randomization study

12 citations , November 2024 in “Journal of Ovarian Research”

Certain inflammatory factors may increase or decrease the risk of developing PCOS.

TREM2+ Macrophages Inhibit Hair Growth by Producing Oncostatin M

research TREMendous Macrophages Inhibit Hair Growth

4 citations , April 2019 in “Cell Stem Cell”

Certain immune cells in the skin can stop hair from growing.

research Pilomatricoma with Florid Osseous Metaplasia: A Cytologist’s Perspective

April 2024 in “Journal of Cytology”

A rare skin tumor with bone formation was successfully removed without recurrence.

research Effects of Cudrania tricuspidata and Sargassum fusiforme extracts on hair growth in C57BL/6 mice

February 2023 in “Laboratory Animal Research”

Cudrania tricuspidata and Sargassum fusiforme extracts improved hair growth in mice by affecting growth-related genes.

research 702 dsRNA induces ectopic KRT9 expression via WNT/β-catenin-mediated signaling

April 2016 in “Journal of Investigative Dermatology”

Double-stranded RNA activates a pathway that causes a skin protein to be expressed in the wrong place.

research Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production

22 citations , April 2020 in “Scientific reports”

Changthangi goats have specific genes that help produce Pashmina wool.

research Protective Role of Melatonin and Its Metabolites in Skin Aging

32 citations , January 2022 in “International Journal of Molecular Sciences”

Melatonin, a hormone, can help protect skin from aging by reducing stress, inflammation, and damage, and may also help treat hair loss in women.

research Research Progress in Chronic Autoimmune Urticaria

2 citations , November 2019 in “International Journal of Dermatology and Venereology”

Chronic autoimmune urticaria can be managed with specific therapies and requires improved diagnosis and treatment methods.

research Iatrogen male infertility

June 1998 in “Biomedicine & Pharmacotherapy”

Medical treatments like chemotherapy and radiotherapy can harm sperm production, so freezing sperm before treatment is important for men who want children later.

research Comparative regenerative mechanisms across different mammalian tissues

252 citations , February 2018 in “npj Regenerative Medicine”

Understanding different species' regeneration can improve mammalian healing.

research Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration

220 citations , March 2020 in “Advanced functional materials”

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

research The blastema and epimorphic regeneration in mammals

85 citations , December 2017 in “Developmental Biology”

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

research Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing

66 citations , May 2021 in “Science Advances”

Different scaffold patterns improve wound healing and immune response in mouse skin, with aligned patterns being particularly effective.

research Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases

59 citations , June 2022 in “Frontiers in medicine”

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

research Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment

38 citations , July 2021 in “ACS Nano”

Microneedles help treat hair loss by improving hair surroundings and promoting growth.

research Immune modulation of hair follicle regeneration

29 citations , May 2020 in “npj Regenerative Medicine”

Immune cells help regulate hair growth, and better understanding this can improve hair loss treatments.

research Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after wounding

28 citations , October 2019 in “Seminars in Cell & Developmental Biology”

Hair can regrow in large wounds through a process similar to how hair forms in embryos, and understanding this could lead to new treatments for hair loss or scarring.

research Molecular elements of the regulatory control of keratin filament modulator AHF/trichohyalin in the hair follicle

7 citations , July 2008 in “Experimental Dermatology”

The study concluded that a protein important for hair strength is regulated by certain molecular processes and is affected by growth phases.

research Impact of Preservation Solutions on the Trichogenicity of Hair Micrografts Ascertained by Dermal Papilla Gene Expression

6 citations , March 2019 in “Dermatologic surgery”

Chilled ATPv-supplemented saline best preserves hair grafts' key genes.

Efficacy and Influence Factors of 308-nm Excimer Lamp with Minoxidil in the Treatment of Alopecia Areata

research Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During The Cashmere Growth Cycle in Capra Hircus

October 2021 in “Research Square (Research Square)”

Melatonin affects certain genes and pathways involved in cashmere goat hair growth.