research Increased androgen bioavailability is associated with non-alcoholic fatty liver disease in women with polycystic ovary syndrome
Women with PCOS and higher androgen levels are more likely to have fatty liver disease.
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research Patient’s experience with subcutaneous and oral methotrexate for the treatment of rheumatoid arthritis
Methotrexate for rheumatoid arthritis often causes side effects like diarrhea, fatigue, and hair loss, especially at higher doses.
research Teriflunomide: a novel oral treatment for relapsing multiple sclerosis
Teriflunomide is an effective and safe first-line oral treatment for relapsing multiple sclerosis.
research Mechanism of apoptosis in oral squamous cell carcinoma promoted by cardamonin through PI3K/AKT signaling pathway
Cardamonin may help treat oral cancer by promoting cell death and stopping cancer cell growth.
research Drug interactions between herbal medicines and oral contraceptives
Herbal medicines can reduce the effectiveness of birth control pills.
research PLASMA C19 STEROID SULPHATE LEVELS AND INDICES OF ANDROGEN BIOAVAILABILITY IN FEMALE PATTERN ANDROGENIC ALOPECIA
Women with female pattern hair loss have higher levels of certain androgens, suggesting increased androgen exposure to hair follicles.
research Long-Term Clinical Effects, Bioavailability, and Kinetics of Minoxidil in Relation to Renal Function
research A Simple Decision Tree Suited for Identification of Early Oral Drug Candidates With Likely Pharmacokinetic Nonlinearity by Intestinal CYP3A Saturation
The decision tree can predict drug absorption issues with good accuracy but needs more validation and adjustments for other factors.
research Dermatologic Manifestations of Polycystic Ovary Syndrome
Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.
research Open-Label, Randomized, Multicenter, Phase III Study Comparing Oral Paclitaxel Plus Encequidar Versus Intravenous Paclitaxel in Patients With Metastatic Breast Cancer
Oral paclitaxel plus encequidar improved tumor response and caused less neuropathy but more serious infections than intravenous paclitaxel.
research Oral delivery of marine shellfish supramolecule peptides for skin wound healing
Eating peptides from certain shellfish may help wounds heal faster by reducing inflammation.
research Treatment of hirsutism with the pure antiandrogen flutamide
Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.
research Sublingual minoxidil for the treatment of male and female pattern hair loss: a randomized, double‐blind, placebo‐controlled, phase 1B clinical trial
Sublingual minoxidil safely promotes hair growth.
research Use of Minoxidil Sulfate versus Minoxidil Base in Androgenetic Alopecia Treatment: Friend or Foe?
Minoxidil base is preferred for hair loss treatment, but minoxidil sulfate may be an alternative for unresponsive patients.
research Is the Safety of Finasteride Correlated With Its Route of Administration: Topical Versus Oral? A Pharmacovigilance Study With Data From the United States Food and Drug Administration Adverse Event Reporting System
Topical finasteride may be safer than oral finasteride, but more research is needed.
research Medical treatment of hirsutism
The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.
research Ritlecitinib: First Approval
Ritlecitinib is approved in the USA and Japan for treating severe hair loss in people aged 12 and older.
research Targets to treat androgen excess in polycystic ovary syndrome
The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.
research Effect of finasteride particle size reduction on its pharmacokinetic, tissue distribution and cellular permeation.
Smaller finasteride particles increase effectiveness in treating hair loss.
research Formulation of a film-coated dutasteride tablet bioequivalent to a soft gelatin capsule (Avodart®): Effect of γ-cyclodextrin and solubilizers
Created tablet similar to Avodart using γ-cyclodextrin and solubilizers.
research ORAL AND TOPICAL FINASTERIDE IN THE TREATMENT OF MALE ANDROGENETIC ALOPECIA – NARRATIVE REVIEW
Finasteride effectively treats male hair loss, with oral and topical forms improving hair growth, but oral use may have side effects.
research Exploring the therapeutic potential of phytochemicals apigenin and ellagic acid in managing polycystic ovarian syndrome and its comorbidities: a comprehensive review
Apigenin and ellagic acid may help manage PCOS symptoms.
research Polycystic ovary syndrome
PCOS is a complex condition with major health impacts, needing more research for better diagnosis and treatment.
research American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1
The guide recommends specific methods for diagnosing PCOS and various treatments for its symptoms, while considering the health impacts on adolescents.
research Evidence-Based and Potential Benefits of Metformin in the Polycystic Ovary Syndrome: A Comprehensive Review
Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.
research Cosmetics and Cosmeceutical Applications of Chitin, Chitosan and Their Derivatives
Chitin and chitosan are useful in cosmetics for oral care, haircare, and skincare, including UV protection and strength improvement.
research The diagnosis and treatment of iron deficiency and its potential relationship to hair loss
Iron deficiency may be related to hair loss, but there's not enough evidence to recommend iron screening or supplements for all hair loss patients.
research Oxidative stress in ageing of hair
Oxidative stress contributes to hair graying and loss as we age.
research Acne and Systemic Disease
Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.
research Management of Hair Loss
Minoxidil and finasteride are effective for male hair loss, minoxidil for female hair loss, and various treatments like corticosteroids work for alopecia areata; treatment should be tailored to the individual.