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Candidate SNP Markers of Reproductive Potential Predicted by Significant Change in Affinity of TATA-Binding Protein for Human Gene Promoters

research Candidate SNP markers of reproductive potential are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters

16 citations , February 2018 in “BMC Genomics”

Certain genetic markers linked to reproductive potential were identified by their impact on a protein's ability to bind to genes.

research Central Centrifugal Cicatricial Alopecia Associated With PDL1 Loss and Increased Expression of Caspase 3: A Case Series

2 citations , April 2023 in “American Journal of Dermatopathology”

CCCA may involve the PD1/PDL1 pathway and increased caspase 3, leading to permanent hair loss.

research SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation

April 2026 in “Cellular and Molecular Immunology”

SPT6 prevents excessive skin inflammation by blocking a feedback loop.

research 303 The role of rare variants in male-pattern hair loss: Analysis of whole exome sequencing data in the UK Biobank

November 2022 in “Journal of Investigative Dermatology”

Rare genetic variants in 125 genes are linked to male-pattern hair loss.

research Human Hairless Protein Roles in Skin/Hair and Emerging Connections to Brain and Other Cancers

15 citations , May 2017 in “Journal of Cellular Biochemistry”

The hairless protein is important for skin, hair, and may influence cancer development.

research 1326 Hes1 regulates anagen initiation and hair follicle regeneration through modulation of hedgehog signaling

April 2018 in “Journal of Investigative Dermatology”

research Gene Expression Profiles of Melanocytes Over-Expressing miR-5110 in Alpaca

January 2026 in “Current Issues in Molecular Biology”

miR-5110 affects alpaca pigmentation by altering specific gene expressions.

research Phospholipase C 1 is required for skin stem cell lineage commitment

101 citations , June 2003 in “The EMBO Journal”

Phospholipase Cδ1 is crucial for normal skin and hair development.

research Folliculin: A surprising molecular brake in the human hair follicle

March 2026 in “Journal of Investigative Dermatology”

Folliculin slows hair growth, and blocking it might help treat hair loss.

research Identification of the Rat Rex Mutation as a 7-bp Deletion at Splicing Acceptor Site of the Krt71 Gene

45 citations , January 2010 in “Journal of Veterinary Medical Science”

A gene mutation causes curly hair and hair loss in rats.

Physiological Functions of PP2A: Lessons from Genetically Modified Mice

research Physiologic functions of PP2A: Lessons from genetically modified mice

87 citations , July 2018 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research”

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

research Krt6a-Cre Transgenic Mice Direct LoxP-Mediated Recombination to the Companion Cell Layer of the Hair Follicle and Following Induction by Retinoic Acid to the Interfollicular Epidermis

10 citations , January 2004 in “Journal of Investigative Dermatology”

Krt6a-Cre transgenic mice help study gene effects on hair follicle development and tumor suppression.

research The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor

16 citations , August 2021 in “Tumor Biology”

TMPRSS2 helps viruses enter cells and protects the prostate from inflammation-related cancer.

research Multi-omics analysis unveils the role of cancer-associated fibroblasts in cutaneous squamous cell carcinoma

November 2025 in “Cancer Cell International”

Cancer-associated fibroblasts promote tumor growth in skin cancer.

research Increased Expression of TSPEAR in Colorectal Cancer Predicts Poor Prognosis

February 2022 in “Research Square (Research Square)”

High TSPEAR levels in colorectal cancer predict worse outcomes.

research A novel homozygous variant in the dsp gene underlies the first case of non-syndromic form of alopecia

2 citations , July 2015 in “Archives of Dermatological Research”

A new gene variant in the DSP gene is linked to a unique type of hair loss.

research Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis

65 citations , November 2013 in “The EMBO Journal”

HDAC1 is crucial for skin development and preventing tumors.

research Novel Effect of Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) on Hair Follicle Cells Proliferation and Hair Growth

1 citations , August 2023 in “Biomolecules & therapeutics”

HAPLN1 can promote hair growth and may help treat hair loss.

research Pathogenic CD8+ T cells target K71+ Henle’s layer by forming cytolytic immune synapses in Alopecia Areata

April 2026 in “Research Square”

research Abstract 2962: Chemotherapy induced senescence drives peripheral neuropathy

March 2024 in “Cancer Research”

Eliminating senescent cells can prevent and reverse chemotherapy-induced peripheral neuropathy.

research Commentary on BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas

January 2019 in “Dermatologic Surgery”

research Mice Expressing a Mutant Krt75 (K6hf) Allele Develop Hair and Nail Defects Resembling Pachyonychia Congenita

46 citations , September 2007 in “Journal of Investigative Dermatology”

research EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression

12 citations , July 2020 in “Aging”

The protein EZH2 blocks microRNA-22, increasing STK40 protein, which helps hair follicle stem cells change and grow hair.

research First-in-human phase 1 study of ETC-159 an oral PORCN inhbitor in patients with advanced solid tumours.

33 citations , May 2017 in “Journal of Clinical Oncology”

ETC-159 was safe up to 30 mg, but no tumor shrinkage was seen.

research Protease-Activated Receptor-1 (Thrombin Receptor) Is Expressed in Mesenchymal Portions of Human Hair Follicle

7 citations , September 2003 in “Journal of Investigative Dermatology”

PAR-1 may play a role in hair growth regulation in human hair follicles.

research MicroRNA-149-Mediated MAPK1/ERK2 Suppression Attenuates Hair Follicle Stem Cell Differentiation

2 citations , February 2022 in “Human Gene Therapy”

Increasing miR-149 reduces hair follicle stem cell growth and hair development by affecting certain cell growth pathways.

CD27 and IL-35 as Diagnostic Biomarkers in Alopecia Areata: First Evidence of Association with Pathogenic Scalp Bacterial Infections

research CD27 and IL-35 as diagnostic biomarkers in alopecia areata: First evidence of association with pathogenic scalp bacterial infections

December 2025 in “Babcock University Medical Journal”

CD27 and IL-35 can help diagnose alopecia areata linked to bacterial infections.

research KERATIN PHENOTYPES IN BASAL-CELL CARCINOMAS OF THE SKIN

7 citations , March 1993 in “International Journal of Oncology”

Basal cell carcinoma shows keratin patterns similar to hair follicle structures.

research The role of hsa‐miR‐193a‐5p as an important factor for control of inositol in alopecia areata

June 2024 in “Skin Research and Technology”

hsa-miR-193a-5p may help diagnose and treat alopecia areata.

research Bioassay-guided isolation of two antiproliferative metabolites from Pterocarpus indicus Willd. against TGF-β-induced prostate stromal cells (WPMY-1) proliferation via PI3K/AKT signaling pathway

3 citations , October 2024 in “Frontiers in Pharmacology”

Compounds from Pterocarpus indicus may help treat benign prostatic hyperplasia by stopping cell growth.

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