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Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The vitamin D receptor can regulate genes and affect hair and hormone levels without its usual activator.

PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.

Pfizer found that pantolactam-based compounds can reduce sebum (skin oil) production when applied topically.

Non-canonical Wnt signaling helps intestinal stem cells move to injury sites for tissue repair.

Enhanced stem cells from the placenta can help treat Graves' eye disease by stopping fat cell growth.

CRF can cause hair loss, but blocking its receptors might prevent this.

Thioredoxin reductase 1 does not affect glucocorticoid receptor activity in hair follicle cells.

ODC expression in mouse skin and tumors is varied and can be inhibited by retinoic acid or cycloheximide.

Potassium channels are important drug targets for treating conditions like hypertension, hair loss, and diabetes.

TPA promotes hair growth by increasing stem cell activity and activating specific cell signals.

Androgen-deprivation therapies increase the risk of certain heart conditions, but testosterone treatment may help.

Seven new genetic risk areas for prostate cancer were found.

A genetic change in the EDAR gene causes the unique hair traits found in East Asians.

EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.

Inhibiting the PI3K/Akt pathway may help prevent radiation-induced liver injury.

EPDS and MS might share an immune-related cause.

Natural compounds may help treat advanced papillary thyroid cancer by targeting specific molecular pathways.

NDP-MSH protects brain cells and reduces inflammation in Parkinson's disease by activating MC1R and involving Tregs.

Overexpression of hurpin in mice leads to abnormal skin and higher skin cancer risk.

ME1 and PPAR signaling may influence hair loss in androgenetic alopecia.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

A new method allows for controlled, long-lasting delivery of retinoic acid through the skin with fewer side effects.

Human placenta extract reduces inflammation and symptoms in atopic dermatitis.

New mutations in the VDR gene cause vitamin D-resistant rickets without hair loss.

Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.