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GlossaryPermeation Studies

measure substance passage through barriers like skin or membranes

Permeation studies are scientific tests used to measure how substances, such as drugs or chemicals, pass through a barrier, like skin or a membrane. These studies are crucial in fields like dermatology and pharmacology to understand how effectively a treatment can penetrate the skin and reach its target area.

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Development and Ex-Vivo Skin Permeation Studies of Finasteride–Poly(Lactic Acid-Co-Glycolic Acid) and Minoxidil–Chitosan Nanoparticulate Systems

research Development and ex-vivo skin permeation studies of finasteride–poly(lactic acid-co-glycolic acid) and minoxidil–chitosan nanoparticulate systems

12 citations , March 2020 in “Journal of Bioactive and Compatible Polymers”

Nanoparticles show potential for controlled release of hair loss drugs, improving treatment effectiveness.

research Simple and Selective HPLC-UV/Vis Bioanalytical Method to Determine Aluminum Phthalocyanine Chloride in Skin Permeation Studies

8 citations , January 2018 in “Journal of Analytical Methods in Chemistry”

A new method accurately measures a drug in skin for cancer therapy research.

Targeting Potential of Zinc Oxide Nanoparticles and Finasteride-Loaded Nano Lipidic Carriers-Infused Topical Gel: In Vitro and In Vivo Skin Permeation Studies

research Targeting Potential of Zinc Oxide Nanoparticles and Finasteride-loaded Nano Lipidic Carriers-infused Topical Gel - In vitro and In vivo Skin Permeation Studies

November 2023

The new gel with Zinc Oxide nanoparticles and finasteride shows promise for treating hair loss when applied to the skin.

research Fabrication of Thymoquinone and Ascorbic Acid-Loaded Spanlastics Gel for Hyperpigmentation: In Vitro Release, Cytotoxicity, and Skin Permeation Studies

4 citations , January 2025 in “Pharmaceutics”

The gel is a safe and effective treatment for hyperpigmentation.

New Insight for Enhanced Topical Targeting of Caffeine for Effective Cellulite Treatment: In Vitro Characterization, Permeation Studies, and Histological Evaluation in Rats

research New Insight for Enhanced Topical Targeting of Caffeine for Effective Cellulite Treatment: In Vitro Characterization, Permeation Studies, and Histological Evaluation in Rats

7 citations , October 2024 in “AAPS PharmSciTech”

CA-SLN-Ngel significantly reduces cellulite more effectively than regular caffeine gel.

research Preparation, Optimization, In vitro Evaluation and Ex vivo Permeation Studies of Finasteride loaded gel Formulations Prepared by using Response SurfaceMethodology

3 citations , September 2018 in “Current Drug Delivery”

The combination of propylene glycol and Tween® 80 improves finasteride gel effectiveness.

research Targeting Potential of Zinc Oxide Nanoparticles and Finasteride-loaded Nano Lipidic Carriers-infused Topical Gel - In vitro and In vivo Skin Permeation Studies

February 2024 in “International journal of pharmaceutical sciences and nanotechnology”

Nanocarriers in gel may reduce side effects of oral hair loss treatments.

research 501 Next-generation in vitro testing: microfluidic models for aging, wound healing, and oral tissue analysis in safety, efficacy, and permeation studies

November 2024 in “Journal of Investigative Dermatology”

Microfluidic models improve testing for aging, wound healing, and oral tissue, reducing animal testing.

Systematically Optimized Coenzyme Q10-Loaded Novel Proniosomal Formulation for Treatment of Photo-Induced Aging in Mice: Characterization, Biocompatibility Studies, Biochemical Estimations, and Anti-Aging Evaluation

research Systematically optimized coenzyme q10-loaded novel proniosomal formulation for treatment of photo-induced aging in mice: characterization, biocompatibility studies, biochemical estimations and anti-aging evaluation

28 citations , August 2015 in “Journal of Drug Targeting”

The new CoQ10 gel protects mouse skin better against aging from UV light than the old gel.

Drug Permeation Through Hair Follicles: Importance and Potential

research Related Topic: Drug Permeation Through Hair Follicles

1 citations , January 2017 in “Springer eBooks”

Hair follicles are important for drug delivery through the skin, but better methods are needed to understand and improve this process.

Application of Validated UV Spectrophotometric and Colorimetric Method to Quantify Minoxidil in the Development of Trilayer Dissolving Microneedle: Proof of Concept in Ex Vivo and In Vivo Studies in Rats

research Application of validated UV spectrophotometric and colorimetric method to quantify minoxidil in the development of trilayer dissolving microneedle: Proof of concept in ex vivo and in vivo studies in rats

December 2023 in “Annales Pharmaceutiques Françaises”

The UV–Vis Spectrophotometry method effectively measures minoxidil in rat skin for alopecia treatment.

research Generic Development of Topical Dermatologic Products: Formulation Development, Process Development, and Testing of Topical Dermatologic Products

188 citations , October 2012 in “The AAPS Journal”

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

research Niosomes as Vesicular Nanocarriers in Cosmetics: Characterisation, Development and Efficacy

14 citations , February 2025 in “Pharmaceutics”

Niosomes improve delivery and effectiveness of cosmetic ingredients.

research Synthesis and Evaluation of Finasteride-Loaded HPMC-Based Nanogels for Transdermal Delivery: A Versatile Nanoscopic Platform

2 citations , January 2022 in “BioMed Research International”

Finasteride-loaded nanogels are effective, safe, and improve drug absorption through the skin.

research Formulation and design of finasteride coated microneedles

January 2021 in “Zenodo (CERN European Organization for Nuclear Research)”

Finasteride-coated microneedles effectively deliver the drug with minimal scalp damage and high stability.

research Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases

26 citations , January 2024 in “Gels”

Nanoemulgels could effectively treat skin diseases and may replace or complement current therapies.

research Formulation and Characterization of Transethosomes for Enhanced Transdermal Delivery of Propranolol Hydrochloride

11 citations , January 2020 in “Micro and Nanosystems”

The new gel improves skin delivery of a drug, potentially reducing dose frequency and side effects.

research Cutaneous Permeation and Penetration of Sunscreens: Formulation Strategies and In Vitro Methods

79 citations , December 2017 in “Cosmetics”

Effective sunscreen formulations can reduce skin absorption and enhance protection.

Age, Health, and Attractiveness Perception of Virtual Human Hair

research Age, Health and Attractiveness Perception of Virtual (Rendered) Human Hair

11 citations , December 2016 in “Frontiers in Psychology”

Hair style affects perceptions of age, health, and attractiveness more than hair color does.

research Perception of Hair Transplant for Androgenetic Alopecia

24 citations , August 2016 in “JAMA Facial Plastic Surgery”

Hair transplants make people look more attractive, successful, approachable, and younger.

research Transdermal Permeation of Drugs in Various Animal Species

149 citations , September 2017 in “Pharmaceutics”

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

research Are We Ready to Measure Skin Permeation of Modern Antiaging GHK–Cu Tripeptide Encapsulated in Liposomes?

1 citations , January 2025 in “Molecules”

More research is needed to effectively measure how well GHK–Cu in liposomes penetrates the skin.

Niosomal Versus Cubosomal Gels of Cetirizine Hydrochloride: Cost-Effective Permeation Enhancement for Potential Transdermal Application

research Niosomal versus cubosomal gels of cetirizine hydrochloride: Cost-effective permeation enhancement for potential transdermal application

October 2025 in “Pharmaceutical Development and Technology”

Cubosomal gels enhance skin absorption of cetirizine better than niosomal gels.

research Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin

22 citations , September 2022 in “International Journal of Nanomedicine”

CUR-loaded micelles improve skin delivery and effects of curcumin for pain and infections.

research Enhancement of drug permeation across skin through stratum corneum ablation

January 2024 in “RSC pharmaceutics”

Removing the outer skin layer increases drug absorption and offers non-invasive treatment options, with some methods allowing for quick skin recovery.