research Pharmacodynamic modeling of finasteride, a 5 alpha-reductase inhibitor.
Finasteride, a drug that changes testosterone to a different hormone, was studied and its effects over time were modeled successfully.
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research Whole-genome sequencing of eight goat populations for the detection of selection signatures underlying production and adaptive traits
Researchers identified genes linked to coat color, body size, cashmere production, and high altitude adaptation in goats.
research Evaluation of the predictive capacity of DNA variants associated with straight hair in Europeans
Certain DNA variants can predict straight hair in Europeans but are not highly specific.
research Clinical Management of Prostate Cancer in High-Risk Genetic Mutation Carriers
More research and guidelines are needed for managing prostate cancer in people with high-risk genetic mutations.
research Development of validated methods for the simultaneous quantification of Finasteride and Tadalafil in newly launched FDA-approved therapeutic combination: greenness assessment using AGP, analytical eco-scale, and GAPI tools
The study developed accurate, precise, and environmentally friendly methods to measure Finasteride and Tadalafil in a new FDA-approved combination.
research Drug-associated gingival disorders: a retrospective pharmacovigilance assessment using disproportionality analysis
Certain medications can cause gum problems, so patients and healthcare providers should be aware and monitor oral health.
research Editorial: Prevention and treatment of skin diseases
Personalized medicine and new technologies offer promising strategies for better skin disease treatments.
research Selected variants of the melanocortin 4 receptor gene (MC4R) do not confer susceptibility to female pattern hair loss
MC4R gene variants not linked to female hair loss.
research MARFATIA AWARD
The document presents three studies. The first study, conducted in Telangana, assessed the validity of a two-staged screening method for identifying youth at high risk for psychosis. It involved 2,025 participants and found that the Prime Screen Revised (PS-R) had high sensitivity (98.41%) and specificity (90.74%) for predicting psychosis transition, with a hazard ratio of 11.4. The second study examined the association between valproate levels, biotinidase activity, and hair loss in 150 participants, finding a significant link between valproate use and hair loss, with 24% of the study group experiencing hair loss compared to 2.66% in the control group. The third study evaluated the Indian Disability Evaluation and Assessment Scale (IDEAS) for assessing disability in common mental disorders, finding strong concurrent validity with the Sheehan Disability Scale (SDS) among 220 patients.
research Pallister-Killian Syndrome
Pallister-Killian Syndrome is a complex genetic disorder requiring coordinated care and genetic counseling.
research Clinical and genetic findings in a Chinese family with VDR-associated hereditary vitamin D-resistant rickets
A Chinese family had a child with a specific gene mutation causing vitamin D-resistant rickets, but the child improved with calcium and low-dose calcitriol.
research Analysis of Genetic Diversity and Construction of a Core Collection of Ginkgo biloba Germplasm Using EST-SSR Markers
Ginkgo biloba has high genetic diversity, useful for future breeding.
research Re: Associations Between Variants in the Cyclooxygenase 2 Enzyme Gene (PTGS2) and Development of Benign Prostate Enlargement
Certain gene variants may raise the risk of prostate enlargement, but taking NSAIDs could reduce this risk.
research Cross-species amplification of human microsatellite markers in pig-tailed and stump-tailed macaques
Some human genetic markers work for genetic studies in pig-tailed and stump-tailed macaques, which can help in their conservation.
research Microarray analysis reveals distinct RNA expression profiles in endothelial progenitor cells exposed to pro-inflammatory environment or oxidized LDL
Different cells affect hair follicle blood vessels, endothelial cells react differently to inflammation and oxidized fats, and prasugrel better protects heart vessels during a procedure than clopidogrel.
research A genetically informed brain atlas for enhancing brain imaging genomics
GIANT improves brain imaging by using genetics to better map brain regions.
research Preformulation studies of finasteride to design matrix systems for topical delivery
research Azathioprine-induced Agranulocytosis and Severe Alopecia After Kidney Transplantation Associated With a NUDT15 Polymorphism: A Case Report
A woman experienced severe side effects from a drug due to a specific genetic variation, suggesting genetic testing could prevent such risks.
research Signal Detection for Adverse Events of Finasteride Using Korea Adverse Event Reporting System (KAERS) Database
research Clin-Alert
In 2002, various drugs caused serious side effects, including vitamin B12 deficiency, heart issues, blindness, hypersexuality, allergic reactions, blood clotting problems, pupil dilation, capillary leak syndrome, muscle breakdown, hepatitis, skin reactions, and lupus.
research Pediatric Features of Genetic Predisposition to Polycystic Ovary Syndrome
Genetic risk for PCOS can affect children's growth, metabolism, and development from early life into adulthood.
research Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness
A specific genetic mutation may increase male pattern baldness risk, especially in Europeans.
research No genetic support for a contribution of prostaglandins to the aetiology of androgenetic alopecia
Prostaglandins don't genetically contribute to hair loss.
research Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions
Paxillin may help manage androgen-related disorders like PCOS by stabilizing androgen receptor proteins.
research International evidence‐based guideline on assessment and management of PCOS —A Nordic perspective
The guideline refines PCOS diagnosis, promotes a healthy lifestyle, reviews treatments, and stresses long-term follow-up.
research Clinical-exome sequencing unveils the genetic landscape of polycystic ovarian syndrome (PCOS) focusing on lean and obese phenotypes: implications for cost-effective diagnosis and personalized treatment
Early diagnosis and personalized treatment for PCOS are crucial, especially for young women in West Bengal, India.
research Abordagens da farmácia estética no tratamento da alopecia androgenética.
Combining treatments like minoxidil, microneedling, and platelet-rich plasma is more effective for hair loss than using them alone.
research Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors: A Mendelian randomization investigation
Testosterone is linked to cardiovascular risk factors and stroke, but its exact role is unclear.
research Targeting receptor–regulator interactions
New treatments for cancer and skin disorders show promise in disrupting harmful cell interactions and promoting hair growth.
research RESPOSTA TERAPÊUTICA DA ALOPÉCIA ANDROGENÉTICA APÓS DRUG DELIVERY DIGITAL COM APLICAÇÃO DE PRODEW 500®, NANOFACTOR® AFGF, NANOFACTOR® VEGF, COPPER PEPTÍDEO®, PROHAIRIN B4®, CAPILLISIL HC® E ARCT-ALG®
The document does not give specific results for hair loss treatment effectiveness.