August 2024 in “Journal of the American Academy of Dermatology” Nail color change might be an early sign of skin pigmentation from minocycline.
September 2024 in “Pigment International” Vitiligo is now seen as a systemic disease with promising new treatments and may offer protection against some diseases.
PRP injections can improve stress incontinence symptoms in women.
32 citations
,
May 2023 in “Preprints.org” Skin pigmentation varies due to genetics, UV exposure, and medications, with treatments available but requiring medical advice.
Acitretin treatment unexpectedly darkened a patient's gray hair.
2 citations
,
September 2022 The PER3 rs772027021 SNP may cause mild skin pigmentation changes in a new subtype of dyschromatosis universalis hereditaria.
15 citations
,
January 2013 in “Dermatologic Surgery” Epithelial grafting can effectively repigment white hair in vitiligo patients.
2 citations
,
August 2025 in “Reports — Medical Cases Images and Videos” A rare pigmented skin tumor called melanotrichoblastoma was diagnosed in a 51-year-old woman.
January 2018 in “Acta dermato-venereologica”
10 citations
,
August 2016 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” Vitiligo patients often have nail problems, so checking their nails is important.
February 2006 in “Journal of The American Academy of Dermatology” Most patients with anal Pemphigus Vulgaris had repeated episodes but fully recovered with treatment, without long-term problems.
1 citations
,
January 2014 in “Elsevier eBooks” Melanocytes produce melanin; their defects cause vitiligo and hair graying, with treatments available for vitiligo.
10 citations
,
November 2009 in “Pigment cell & melanoma research” The document concludes that MGRN1 affects mouse fur color by interfering with a receptor's signaling, but its full role in the body is still unknown.
17 citations
,
February 2011 in “International Journal of Cosmetic Science” Grey hair is wilder, drier, and less manageable than pigmented hair.
27 citations
,
March 2006 in “Dermatologic surgery” Medical tattooing is a widely accepted, easy, and permanent treatment with few side effects but carries an infection risk without proper sterilization.
2 citations
,
September 2019 in “Neurology Neuroimmunology & Neuroinflammation” IVIg treatment improved symptoms but caused permanent dark hair loss.
PRP injections effectively improve stress urinary incontinence in women.
September 2011 in “Urology” The IPP index is linked to storage symptoms and leftover urine, and may help manage urinary tract symptoms.
31 citations
,
February 1999 in “Dermatologic surgery” Sun exposure after laser hair removal can cause skin darkening, which is hard to treat and requires avoiding UV light.
9 citations
,
December 2010 in “Journal of The European Academy of Dermatology and Venereology” Latanoprost therapy potentially caused a woman's white hair to darken again.
2 citations
,
November 1995 in “American Journal of Obstetrics and Gynecology” Taking vitamin B6 corrected a pregnant woman's metabolic disorder, which changed her hair color.
2 citations
,
January 1999 in “Dermatology” 16 citations
,
February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
4 citations
,
July 2019 in “Clinics in Dermatology” The document concludes that while white skin, nail, and mucosa diseases increase skin cancer risk, they are generally harmless, especially compared to darker pigmentation conditions.
September 2024 in “Journal of Investigative Dermatology” This pilot study explores the role of vasoactive intestinal peptide (VIP) as a negative regulator of human hair follicle pigmentation using ex vivo assays with scalp hair follicles from 4 male donors. The study found that VIP significantly reduces melanin production and tyrosinase activity, indicating an inhibition of melanogenesis at the post-dopachrome tautomerase level. Additionally, higher concentrations of VIP decreased the number of differentiated melanocytes without affecting apoptosis, suggesting an inhibition of melanocyte differentiation rather than survival. These findings imply that VIP may play a role in stress-induced hair graying and other depigmentation disorders, warranting further research in larger cohorts and potential therapeutic applications of VIP receptor antagonists.
2 citations
,
January 2015 in “Chinese Medical Journal” Lithium can cause skin discoloration even at normal levels, so monitor for signs of intoxication.
22 citations
,
September 2008 in “International Journal of Dermatology” The case suggests a possible autoimmune link between lichen sclerosus and vitiligo.
11 citations
,
April 2013 in “Homo” Darker skin in 10-year-old girls may be an early sign of puberty.
January 2008 in “대한피부과학회지” Micropigmentation is a safe procedure that effectively improves the appearance of scars on the scalp and eyebrows, with most patients showing excellent or good results.
February 2026 in “Frontiers in Medicine” Combining hyaluronic acid and oxygen may help improve urinary incontinence in menopausal women.