TLR3 signaling enhances the immunosuppressive properties of human periodontal ligament stem cells.
184 citations
,
September 2006 in “PLoS Genetics” The Apc gene is crucial for normal skin and thymus development.
138 citations
,
June 2012 in “Genes & Development” Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.
128 citations
,
August 2015 in “Cell Stem Cell” Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.
47 citations
,
January 2019 in “Nature communications” Polyamines help fix DNA damage accurately in cells.
42 citations
,
January 2008 in “Dermatology” Dermoscopy effectively distinguishes between acute total hair loss and other types of female hair loss.
39 citations
,
April 2015 in “Regeneration” Lizards can regrow their tails, and studying this process helps understand scar-free healing and limb regeneration.
39 citations
,
December 2001 in “JNCI: Journal of the National Cancer Institute” Using a gene therapy with the Sonic Hedgehog gene helps mice regrow hair faster after losing it from chemotherapy.
36 citations
,
January 2014 in “Evidence-based Complementary and Alternative Medicine” Pumpkin seed oil helps hair growth in men with hair loss.
26 citations
,
May 2014 in “BioEssays” Using neurohormones to control keratin can lead to new skin disease treatments.
22 citations
,
June 1980 in “International Journal of Dermatology” The document concludes that correct diagnosis of alopecia types is crucial, scalp biopsies are important, and more research is needed.
20 citations
,
December 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” Blocking IL-12/IL-23 does not help with hair loss in alopecia areata for mice or humans.
19 citations
,
August 2012 in “Cell death and differentiation” Intu gene is crucial for hair follicle formation by helping keratinocytes differentiate through primary cilia.
13 citations
,
August 2020 in “Frontiers in Immunology” Gamma delta T cells in the skin help with healing and defense but can also cause autoimmune issues, and more research is needed to understand how they are activated.
9 citations
,
January 2017 in “Organic Process Research & Development” In 2017, a new method was created to efficiently produce a topical antiandrogen, a compound used to treat excess sebum and acne, with a high yield and purity.
9 citations
,
July 2001 in “Cell” Cells from certain embryo parts can induce head formation in another embryo, involving complex signaling pathways.
7 citations
,
January 2023 in “Frontiers in cell and developmental biology” Celsr1 is crucial for skin cell alignment, while Celsr2 has little effect on this process.
5 citations
,
October 2024 in “International Journal of Biological Sciences” A peptide from hair follicle stem cells can boost hair growth.
3 citations
,
April 2010 in “Endocrinology” The mouse model suggests male pattern baldness may be due to an enzyme increasing DHT and higher androgen receptor levels in hair follicles.
1 citations
,
November 2017 The document concludes that while some organisms can regenerate body parts, mammals generally cannot, and cancer progression is complex, involving mutations rather than a strict stem cell hierarchy.
The mesenchymal stem cell secretome may effectively treat various diseases as an alternative to traditional stem cell therapies.
December 2023 in “Biological & pharmaceutical bulletin” IPM enhances skin penetration of hydrophilic drugs.
January 2018 in “Springer eBooks” PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.
August 2021 in “Journal of advances in medicine and medical research” Excimer light therapy is more effective than low level laser therapy for treating alopecia areata.
20 citations
,
April 2020 in “Journal of advanced Biomedical and Pharmaceutical Sciences” Niosomal methylene blue gel effectively improves moderate to severe acne.
14 citations
,
January 2005 in “Pediatric Dermatology” UVA1-light therapy successfully treated a child's skin condition, mycosis fungoides.
10 citations
,
March 2024 in “Frontiers in Bioengineering and Biotechnology” Photothermal hydrogels can kill bacteria and help heal tissue using light-converted heat.
6 citations
,
May 2022 in “Pharmaceutics” Zinc pyrithione dissolves quickly on the skin and in hair follicles, especially in smaller particles.
January 1963 in “Stain technology” Ziehl-Neelsen's stain helps identify different parts of hair in sheep and goats.
January 2019 in “Dermatologic Surgery” Pulsed Dye Laser effectively treats skin lesions in Rosai–Dorfman Disease.