research Premature aging and cancer development in transgenic mice lacking functional CYLD
Lack of functional CYLD in mice leads to early aging and cancer.
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research Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts
Cyanidin 3-O-arabinoside may help treat a common form of hair loss by protecting cells against aging and improving cell function.
research Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo
Adult skin cell-based early-stage skin substitutes improve wound healing and hair growth in mice.
research Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development
MicroRNAs are important for hair growth regulation, with Dicer being crucial and Tarbp2 less significant.
research Exploring machine learning strategies for single-cell transcriptomic analysis in wound healing
Machine learning and single-cell analysis improve understanding and treatment of wound healing.
research Physiological skin oxygen levels: An important criterion for skin cell functionality and therapeutic approaches
Maintaining natural oxygen levels is crucial for healthy skin cells and effective treatments.
research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling
4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.
research Premature hair graying: a multifaceted phenomenon
Premature hair graying is caused by genetics, stress, and lifestyle, and affects mental health.
research 549 Temporary cell cycle arrest in human scalp hair follicles and their epithelial stem cells by ALRN-6924: A novel strategy to selectively protect p53-wildtype cells against paclitaxel-induced alopecia
ALRN-6924 may prevent hair loss caused by chemotherapy.
research Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation
Understanding how certain proteins and genetic changes control skin stem cells is key to treating skin diseases.
research Stem cell-based therapies for alopecia areata: a narrative review
Stem cell therapies show promise for hair regrowth in alopecia areata but need more research for safety and effectiveness.
research The possibilities of correction of premature greying of hair and involutive hair changes
Premature graying and hair changes can be treated with certain peptides and possibly targeting the endocannabinoid system.
research Cell Therapy for Androgenetic Alopecia: Elixir or Trick?
Stem cell therapies could be a promising alternative for hair loss treatment, but more research is needed to understand their full potential and safety.
research 517 Regulation of the lipidome and lipid metabolism in prematurely senescent human dermal fibroblasts
Aging skin cells change their lipid profiles due to stress, affecting skin health.
research Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease
The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.
research Imbalanced redox dynamics induce fibroblast senescence leading to impaired stem cell pools and skin aging
Imbalanced redox dynamics cause skin aging by damaging fibroblasts and stem cells.
research The stem cell niche
Stem cell niches are essential for tissue health and repair.
research Progenitor Cell Dysfunctions Underlie Some Diabetic Complications
Diabetes causes lasting cell dysfunctions, leading to serious complications even after blood sugar is controlled.
research Neuregulin3 alters cell fate in the epidermis and mammary gland
Neuregulin3 affects cell development in the skin and mammary glands.
research Stem Cell Therapies for Epidermolysis Bullosa Treatment
Stem cell therapies may help improve symptoms and quality of life for people with epidermolysis bullosa.
research Progenitor Cell Dynamics in Androgenetic Alopecia: Insights from Spatially Resolved Transcriptomics
Targeting EMT and fibrotic remodeling may help treat androgenetic alopecia.
research Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo
ING5 is crucial for stem cell maintenance and preventing certain cancers.
research Stem Cell-Derived and Plant-Derived Exosomes: Promising Therapeutics for Skin Healing and Regeneration
Stem cell and plant exosomes may help heal and regenerate skin.
research Advances in single-cell transcriptomics in animal research
Single-cell transcriptomics helps improve animal health and productivity by studying gene expression in individual cells.
research Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
Low levels of vitamin B12 and ferritin are linked to early hair graying.
research Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis
Keratin 15 helps maintain skin cell growth and repair.
research A study of micronutrient levels in premature canities in children
Children with early graying hair might have lower levels of certain nutrients like zinc, magnesium, and Vitamin B12.
research Two Opposing Faces of Retinoic Acid: Induction of Stemness or Induction of Differentiation Depending on Cell-Type
Retinoic acid can either maintain stem cells or make them specialize, depending on the cell type.
research Cellular senescence in tissue repair: every cloud has a silver lining
Cell aging can be both good and bad for tissue repair.
research The Stem Cell Niche in Regenerative Medicine
Targeting and modifying the stem cell niche can improve regenerative therapies.