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Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

5α-reductase deficiency can cause ambiguous genitalia and gender dysphoria, treatable with testosterone.

Routine genetic testing is crucial for early diagnosis and better management of Turner’s syndrome with 21-hydroxylase deficiency.

Neurosteroids help protect fetal brains from asphyxia damage.

Testosterone in our bodies helps increase insulin secretion from the pancreas.

Testosterone therapy can improve skin and hair in men with low testosterone but may cause skin irritation with certain treatments.

Mothers with atopic dermatitis have higher risks of pregnancy complications and their children are more likely to develop certain health conditions.

Hair analysis alone can't confirm long-term drug exposure in children under 1 year old.

Testosterone undecanoate safely and effectively increased penis size in male children with 5-alpha-reductase deficiency.

Anastrozole and cyproterone acetate treatment can help increase adult height in boys with testotoxicosis.

During late pregnancy in rats, hormonal changes increased certain GABAA receptors in specific brain cells.

Genetics may play a significant role in gender dysphoria.

Transgender men on testosterone therapy need ongoing gynecologic care due to potential cancer risks.

Prostaglandin D2 increases testosterone levels in skin cells through reactive oxygen species, not enzymes, which could lead to new hair loss treatments.

Male cells need DHT to respond to testosterone, while female cells do not.

Testosterone in human pancreas cells boosts insulin production.

Breathing in newborn rats is affected differently by hormones based on their sex.

Girls with prepubertal simple hypertrichosis have higher dihydrotestosterone (DHT) levels.

The L457(3.43)R mutation in the human lutropin receptor causes increased activity and hormone insensitivity, leading to precocious puberty.

Low testosterone in men is a risk factor for a specific heart rhythm issue, and testosterone treatment may help prevent it.

Formalin-induced pain increases testosterone breakdown in the rat brain and spinal cord.

Exposure to certain sex hormones can increase health risks, while some hormone therapies may offer benefits for specific conditions.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Testosterone therapy in transgender men can cause acne.

Epitestosterone may act as a weak antiandrogen and can inhibit an enzyme involved in testosterone metabolism.

A specific metabolite, not a receptor protein, triggers the production of certain kidney enzymes, but this process is disrupted in mice with a mutation causing testicular feminization.

Parental support and gender-affirming care are crucial for the mental health of transgender adolescents.