May 2023 in “International Journal of Trichology” A witch-hazel-based 5% minoxidil solution is effective and safe for women with hair loss who didn't respond to regular minoxidil, especially if they're sensitive to propylene glycol.
18 citations
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March 2014 in “Drug Development and Industrial Pharmacy” New gel formulas without ethanol and propylene glycol, containing a minoxidil-methyl-β-cyclodextrin complex, have been created for treating hair loss.
January 2021 in “Social Science Research Network” The optimized microemulsion with finasteride and cinnamon oil can effectively deliver the drug through the skin without using ethanol.
1 citations
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January 2022 in “Journal of Drug Delivery Science and Technology” The optimized microemulsion with cinnamon oil effectively delivers finasteride through the skin without damaging hair.
1 citations
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June 2021 in “International journal of pharmaceutical compounding” Minoxidil in FOAMIL is stable for at least 180 days at various concentrations.
February 2024 in “PubMed” The new minoxidil lotion using Aloplus Total is stable and can be mixed with other ingredients for treating hair loss.
4 citations
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January 2009 in “International journal of trichology” Minoxidil topical foam is a better, less irritating treatment for hair loss.
December 2025 in “PubMed” The minoxidil and finasteride foam remains stable and effective for 180 days at room temperature.
4 citations
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January 2016 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)” 5% minoxidil foam is a safe, effective treatment for male pattern hair loss, with increased hair count and few side effects.
7 citations
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February 2019 in “Journal of Molecular Liquids” Minoxidil dissolves better in propylene glycol and water as temperature and propylene glycol amount increase.
January 2021 in “Medical research archives” The 5% minoxidil lotion without propylene glycol is effective, well-tolerated, and cosmetically acceptable for hair loss.
123 citations
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February 2002 in “Journal of The American Academy of Dermatology” Minoxidil can cause skin allergy; use alternative solvents or treatments if allergic.
68 citations
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March 2002 in “Journal of pharmaceutical sciences” Nonionic liposomes are the best for delivering genes to skin cells.
8 citations
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April 2020 in “Journal of The American Academy of Dermatology” Oral minoxidil is a reasonably safe alternative for patients allergic to the topical form.
December 2022 in “Journal of Tropical Pharmacy and Chemistry” The hair tonic made from oil palm leaf extract is very effective in preventing hair damage from the sun.
March 2002 in “Clin-Alert” In 2002, various drugs caused serious side effects, including vitamin B12 deficiency, heart issues, blindness, hypersexuality, allergic reactions, blood clotting problems, pupil dilation, capillary leak syndrome, muscle breakdown, hepatitis, skin reactions, and lupus.
55 citations
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June 2009 in “Journal of Pharmaceutical Sciences” Minoxidil promotes hair growth by penetrating skin, with ethanol-containing formulas working best.
38 citations
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June 2005 in “Contact Dermatitis” Patient had scalp allergy from minoxidil; test helped identify cause and suggest alternative treatments.
34 citations
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September 1985 in “Contact Dermatitis” Minoxidil can cause skin irritation like eczema and rash in some users.
28 citations
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November 2020 in “Fluid Phase Equilibria” Minoxidil dissolves better in propylene glycol + water than in supercritical CO2.
16 citations
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December 2016 in “Skin appendage disorders” Nickel, cobalt, balsam of Peru, fragrance mix, carba mix, and propylene glycol are common allergens causing scalp contact dermatitis.
The new minoxidil gel may improve hair loss treatment by staying on the scalp longer and penetrating better.
7 citations
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January 2021 in “Cureus” A woman had an allergic skin reaction to a hair loss treatment containing minoxidil and should not use it.
Both 5% minoxidil solution and milky lotion effectively and safely treat male hair loss, with the lotion being a good alternative for those sensitive to certain ingredients.
December 2023 in “Journal of molecular structure” Hair treatments and dehydration affect hair's lipid and protein behavior, influencing its flexibility and appearance.
October 2025 in “Journal of Drug Delivery Science and Technology” Resveratrol-loaded carriers may help reduce hair loss from chemotherapy when used with scalp cooling.
August 2025 in “International Journal of Pharmaceutical Sciences and Nanotechnology” The new minoxidil nanoemulgel may treat hair loss more effectively with fewer side effects.
May 2024 in “Pharmacia/Farmaciâ” Purple sweet potato leaf extracts can help treat hair loss and fungal infections.
April 2025 in “Acta Dermato Venereologica” Accurate diagnosis is crucial to distinguish between allergy and irritation from topical minoxidil.
11 citations
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January 2006 in “Drug development and industrial pharmacy” Adding TPGS to minoxidil solutions can improve skin penetration and retention, especially in water and PEG 400-based solutions.