research High-confidence cancer patient stratification through multiomics investigation of DNA repair disorders
CEP135 may predict cancer outcomes, and targeting PLK1 could help treat certain sarcomas.
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research Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin® with Marilex® in Pattern Hair Loss and Telogen Effluvium
Proteoglycans are important for hair growth, and a specific treatment can help reduce hair loss.
research Exploring caspase functions in mouse models
Caspases affect many cell functions and could help treat various diseases.
research T-cell “induced-self” MHC class I/peptide complexes may enable “de novo” tolerance induction to neo-antigens occurring outside of the thymus
Hair follicles may help teach the immune system to tolerate new self-antigens, but this can sometimes cause hair loss.
research Understanding the molecular basis of mesenchymal stem cell stemness: implications for clinical applications
Understanding how mesenchymal stem cells stay undifferentiated can improve their use in treating diseases.
research Structure and Development of the Skin and Cutaneous Appendages
Understanding skin structure and development helps diagnose and treat skin disorders.
research A novel hairless highly immunodeficient mice model optimized for in vivo imaging
The new Hairless R/J mice model improves imaging for tumor monitoring and cancer therapy evaluation.
research JAK-centric explainable few-shot gene-expression diagnosis framework for alopecia via MultiPLIER priors and relation-style set-to-set comparison
A new method helps diagnose alopecia areata using specific gene markers and could guide targeted treatments.
research Identification and single-cell analysis of prognostic genes related to mitochondrial and neutrophil extracellular traps in bladder cancer
Six key genes can predict bladder cancer outcomes and may serve as prognostic biomarkers.
research Fibroblast heterogeneity and functions: insights from single-cell sequencing in wound healing, breast cancer, ovarian cancer and melanoma
Different types of fibroblasts play specific roles in wound healing and cancer, which could help improve treatments.
research Development of novel wound dressing based on elastin-like recombinamers for skin regeneration
Elastin-like recombinamers show promise for better wound healing and skin regeneration.
research T cell and bacterial microbiota interaction at intestinal and skin epithelial interfaces
T cells and bacteria in the gut and skin help maintain health and protect against disease.
research Differentiation of Adipose Derived Stem Cells by Stimulating with Extracellular Vesicles Secreted from Dermal Papilla Cells Activated with Osteogenic and Adipogenic Inducers
Adipose-derived stem cells can be transformed into hair-forming cells using specific extracellular vesicles, offering potential for hair regeneration therapies.
research 1372 Biological effects of electrical epilation on human hair follicles and perifollicular skin ex vivo
Electrical epilation damages hair follicles and surrounding skin, likely preventing hair regrowth.
research 1375 Cutaneous adnexal cysts revisited: A novel classification based on morphological and molecular features
The conclusion introduces a new way to classify skin cysts using their shape and genetic markers.
research 1371 FGF7-dependent inhibition of human hair growth byan osteopontin-derived peptide: A novel solution for hirsutism and hypertrichosis?
A new peptide, FOL-005, may help treat excessive hair growth by reducing a hair growth promoter, FGF7.
research 1370 17β-estradiol may control human HF growth also via up-regulating the expression of cannabinoid receptor type1 expression
17β-estradiol may help hair growth by increasing cannabinoid receptor type 1.
research 1336 The de novo DNA methyltransferase DNMT3A is required for epidermal homeostasis
DNMT3A is crucial for healthy skin and hair growth.
research 251 Morphogenetic events in hair follicle heterotypic spheroids
The research concluded that hyaluronic acid affects the formation and growth of hair follicle-like structures in a lab setting.
research 250 Sweat glands shrink upward with aging, causing dermal layer defects that lead to loss of skin elasticity and wrinkling-establishment of 3D imaging method for skin appendages
Aging causes sweat glands to shrink and move upward, leading to less elastic skin and more wrinkles.
research 307 Dermatologic toxicities associated with chronic gamma-secretase inhibitor treatment for desmoid tumor
Most patients experienced mild to moderate skin problems during a trial for a desmoid tumor treatment.
research Hair Biology and Androgenetic Alopecia
Hair loss caused by genetics and hormones; more research needed for treatments.
research 1334 Beyond goosebumps: Interactions between the hair follicle, the arrector pili muscle, and the sympathetic nerve during development and hair follicle regeneration
Arrector pili muscle regulates hair follicle stem cells, DNA methylation needed for hair cycling, and Wnt/B-catenin signaling starts hair growth.
research Understanding the functional contribution of dermal stem cells to hair follicle regeneration and skin wound healing
Dermal stem cells help regenerate hair follicles and heal skin wounds.
research Follicular Stem Cells in Androgenetic Alopecia
Hair loss in Androgenetic Alopecia is not caused by damage to follicular stem cells.
research Cultured human and rat tooth papilla cells induce hair follicle regeneration and fiber growth
Tooth papilla cells can help regenerate hair follicles and grow hair.
research Screening and Identification of LncRNAs Related to Villus Growth of Liaoning Cashmere Goats and Their Effects on Growth after FGF5 Treatment
Certain long non-coding RNAs in cashmere goats affect hair growth when treated with a specific growth factor.
research Morphogenesis- and Hair Cycle-dependent Expression of Trichohyalin, Peptidylarginine Deiminase Type III and Deiminated Trichohyalin in Rat Dorsal Skin Hair Follicles
THH and PAD type III appear together early in hair growth, but deiminated THH appears later, suggesting another factor is involved.
research Hormesis and medicine
Low doses of some substances can be beneficial, while high doses can be harmful or toxic.
research Hair keratin film as a substitute device for human hair
Keratin film can effectively replace human hair for testing hair damage.