81 citations
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May 2007 in “Fertility and Sterility” Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.
20 citations
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October 2008 in “European journal of endocrinology” Lower lipin 1β in belly fat is linked to insulin resistance in people with polycystic ovary syndrome.
239 citations
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July 2002 in “Clinical and Experimental Dermatology” Low iron and L-lysine levels can cause hair loss in women, and increasing these nutrients can reduce hair shedding.
204 citations
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February 2000 in “Current Medicinal Chemistry” Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.
193 citations
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August 1985 in “Endocrinology” Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.
192 citations
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September 2003 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.
179 citations
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October 2018 in “American Journal of Clinical Dermatology” Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.
153 citations
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January 2001 in “Science” Using CDK inhibitors on rats showed a reduction in chemotherapy-caused hair loss, but later experiments could not repeat these results.
150 citations
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December 2012 in “EMBO Reports” Stem cell self-renewal is complex and needs more research for full understanding.
130 citations
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October 2006 in “Allergy” Allergic reactions to blood thinners are rare but can be serious, requiring careful testing and alternative treatments.
126 citations
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January 2009 in “International Journal of Trichology” Oxidative stress contributes to hair graying and loss as we age.
118 citations
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May 2015 in “European journal of pharmaceutics and biopharmaceutics” The hydrogel with a 1:3 ratio of hydroxyethyl cellulose to hyaluronic acid is effective for delivering drugs through the skin to treat acne.
118 citations
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April 1998 in “Dermatologic Clinics” Finasteride and minoxidil are effective for hair regrowth, while treatments for alopecia areata have varying success and continuous treatment is necessary.
116 citations
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May 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.
110 citations
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July 2010 in “Journal of The American Academy of Dermatology” Hair loss linked to higher heart disease risk in both men and women.
109 citations
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October 2007 in “Journal of pineal research” Melatonin helps regulate hair growth and protects the hair follicle from stress.
103 citations
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June 2006 in “British journal of sports medicine” The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.
97 citations
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December 2010 in “Journal of Neuroscience” Midazolam impairs learning and memory by increasing neurosteroids through specific receptor activation.
91 citations
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May 2005 in “The Journal of Clinical Endocrinology & Metabolism” A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.
77 citations
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August 2025 in “Signal Transduction and Targeted Therapy” Extracellular vesicles show promise for treating diseases but face challenges in development and regulation.
77 citations
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July 2020 in “Journal of the European Academy of Dermatology and Venereology” Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.
75 citations
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June 1999 in “Pediatric Clinics of North America” The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.
72 citations
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January 2001 in “Drugs” Minoxidil and finasteride treat hair loss; more research needed for other options.
67 citations
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September 2003 in “Journal of cutaneous pathology” Skin problems are very common in people with end-stage kidney disease.
64 citations
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November 2012 in “EMBO reports” Lamins are vital for cell survival, organ development, and preventing premature aging.
62 citations
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January 2003 in “Dermatology” Sunlight worsens hair loss; protect scalp.
60 citations
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January 2023 in “Biogerontology” Adequate testosterone is crucial for men's health and quality of life, but its decline with age needs more research.
59 citations
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January 2005 in “Endocrine Journal” Sex steroids influence skin appendage function and neoplasm development, with changes in AR and ERalpha in certain gland neoplasms.
56 citations
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July 2008 in “European journal of endocrinology” Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.
53 citations
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January 2011 in “Diabetes” People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.