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January 2013 in “MedChemComm” PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.
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October 2021 in “Cancer Communications” RC48 shows promise for treating certain advanced cancers, but more research is needed.
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December 1994 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” The treatment effectively reduced hair growth and was safe for patients with PCOS, but it needs better bleeding control.
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December 2024 in “European Journal of Medicinal Chemistry” New pyrazole-based inhibitors show promise for treating metabolic diseases and other conditions.
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June 2011 in “Movement Disorders” THAP1 gene changes do not affect DYT1 dystonia; finasteride may help reduce tics and OCD in Tourette syndrome.
March 2023 in “Frontiers in Cell and Developmental Biology” Proteoglycans are vital for tissue growth and healing, with potential as treatment targets.
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December 2012 in “Epilepsia” Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.
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December 2011 in “Journal of Neuroscience” Neurosteroids are crucial for stress response, and targeting specific receptors may help treat certain disorders.
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February 2017 in “Journal of neuroscience research” Removing certain brain receptors in mice worsens seizure severity and response to treatment during hormone withdrawal.
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March 2023 in “Science Translational Medicine” Blocking a certain signal in the gp130 receptor can improve tissue healing and lessen osteoarthritis symptoms.
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August 2017 in “International Journal of Molecular Medicine” Panax ginseng extract may help prevent hair loss caused by DKK-1.
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September 2025 in “Biomolecules” The effect of GLP-1 RAs on erectile function is unclear and needs more research.
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January 2015 in “Journal of the American Academy of Dermatology” Pioglitazone may help treat lichen planopilaris, but more research is needed.
April 2026 in “Frontiers in Cell and Developmental Biology” G-protein-coupled receptors (GPCRs) are crucial in the wound healing process, influencing immune cell recruitment and signaling pathways like Hedgehog-GLI, Hippo-YAP1, and Wnt/β-catenin, which are involved in epidermal cell proliferation and differentiation. By modifying GPCR activity with agonists or antagonists, it is possible to impact immune cell infiltration, inflammatory mediator production, and the rate of wound healing. This review discusses the fundamental mechanisms of GPCR signaling in wound healing and recent discoveries about their roles and functions.
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June 2015 in “Expert Opinion on Therapeutic Targets” Blocking the prolactin receptor might help treat various diseases, but more research is needed.