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GlossaryQuantitative Real-Time PCR

laboratory technique to amplify and quantify DNA in real-time

Quantitative Real-Time PCR (qPCR) is a laboratory technique used to amplify and simultaneously quantify a targeted DNA molecule. It allows scientists to measure the amount of DNA in a sample in real-time, making it a powerful tool for diagnosing diseases, studying gene expression, and detecting genetic mutations.

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research Molecular mapping of lymph node metastases by real-time reverse transcription polymerase chain reaction in two melanoma patients

March 2011 in “Journal of Dermatology”

The conclusion is that a certain test might help find cancer spread in lymph nodes for melanoma patients, but more research is needed due to false positives.

research Accurate quantification of minimal residual disease at day 15, by real-time quantitative polymerase chain reaction identifies also patients with B-precursor acute lymphoblastic leukemia at high risk for relapse

13 citations , August 2000 in “Blood”

Measuring minimal residual disease on day 15 helps identify high-risk leukemia patients.

research Characterization and expression analysis of KAP7.1, KAP8.2 gene in Liaoning new-breeding cashmere goat hair follicle

48 citations , February 2010 in “Molecular biology reports”

KAP7.1 and KAP8.2 genes are crucial for cashmere quality in goats.

Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

research Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis

38 citations , June 2005 in “Matrix Biology”

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit Hair Follicle Cycle by RNA Sequencing

research Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit (Oryctolagus cuniculus) Hair Follicle Cycle by RNA Sequencing

35 citations , May 2019 in “Frontiers in genetics”

Non-coding RNAs play key roles in the hair growth cycle of Angora rabbits.

Fibromodulin Deficiency Alters Temporospatial Expression Patterns of Transforming Growth Factor-β Ligands and Receptors During Adult Mouse Skin Wound Healing

research Fibromodulin-Deficiency Alters Temporospatial Expression Patterns of Transforming Growth Factor-β Ligands and Receptors during Adult Mouse Skin Wound Healing

32 citations , March 2014 in “PLOS ONE”

Mice lacking fibromodulin have disrupted healing patterns, leading to abnormal skin repair and scarring.

research Lgr6+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors

7 citations , November 2016 in “Oncotarget”

UV exposure reduces Lgr6+ stem cells in mouse skin and they don't significantly contribute to skin cancer development.

research TR3 is preferentially expressed by bulge epithelial stem cells in human hair follicles

7 citations , January 2016 in “Laboratory Investigation”

TR3 is mainly found in hair follicle stem cells and may be involved in hair loss.

research Hair Follicle Transcriptome Analysis Reveals Differentially Expressed Genes That Regulate Wool Fiber Diameter in Angora Rabbits

3 citations , March 2023 in “Biology”

Genes affecting wool fiber thickness in Angora rabbits were identified, which could help breed finer wool.

research The murine hair follicle is a melatonin target

September 2004 in “Experimental dermatology”

Melatonin directly affects mouse hair follicles and may influence hair growth.

research Transcription factor FOXC1 positively regulates SFRP1 expression in androgenetic alopecia

May 2021 in “Experimental Cell Research”

FOXC1 boosts SFRP1 in hair loss, suggesting new treatments.

research Expression patterns of TRα and CRABPII genes in Chinese cashmere goat skin during prenatal development

August 2015 in “Han'gug dongmul jawon gwahag hoeji/Han-guk dongmul jawon gwahak hoeji/Journal of animal science and technology”

TRα and CRABPII genes change their activity levels during goat fetal skin development.

research Spatiotemporal Expression Characterization of KRTAP6 Family Genes and Its Effect on Wool Traits

January 2024 in “Genes”

KRTAP6 genes affect wool quality in sheep.

To Identify the Expression of Intracellular Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Alopecia Areata

research TO IDENTIFY THE EXPRESSION OF INTRACELLULAR TOLL-LIKE RECEPTORS (TLRS) IN PERIPHERAL BLOOD MONONUCLEAR CELLS OF ALOPECIA AREATA

November 2023

Alopecia areata patients have higher levels of certain immune receptors, suggesting new treatment possibilities.

research Effects of Exogenous Melatonin on the Gene Expression of BMP2 in the Skin of Inner Mongolia Cashmere Goat

January 2013

Melatonin reduces BMP2 gene expression in goat hair follicles during the resting period.

research Association Between Human Hair Loss and the Expression Levels of Nucleolin, Nucleophosmin, andUBTFGenes

5 citations , February 2016 in “Genetic Testing and Molecular Biomarkers”

Hair loss is significantly linked to lower levels of certain genes in hair follicles.

research Canine Ringworm Caused by Trichophyton mentagrophytes - Detection by SYBR-Green real-time PCR

3 citations , March 2023 in “ACTA SCIENTIAE VETERINARIAE”

Real-time PCR quickly and accurately detects ringworm in dogs.

research Epithelial–mesenchymal transition in keloid tissues and TGF‐β1–induced hair follicle outer root sheath keratinocytes

46 citations , July 2015 in “Wound repair and regeneration”

Keloid scars may form due to changes in skin cell characteristics and specific protein signaling.

Fibroblast Growth Factor 5-Short (FGF5s) Inhibits the Activity of FGF5 in Primary and Secondary Hair Follicle Dermal Papilla Cells of Cashmere Goats

research Fibroblast growth factor 5-short (FGF5s) inhibits the activity of FGF5 in primary and secondary hair follicle dermal papilla cells of cashmere goats

42 citations , September 2015 in “Gene”

FGF5s can block the effects of FGF5, which may help control hair growth in cashmere goats.

research Homozygous Nonsense Mutation in DSC3 Resulting in Skin Fragility and Hypotrichosis

8 citations , June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

A boy's skin fragility and sparse hair were caused by a genetic mutation affecting skin cell adhesion.

Trastuzumab Induced Chemobrain, Atorvastatin Rescued Chemobrain with Enhanced Anticancer Effect and without Hair Loss Side Effect

research Trastuzumab Induced Chemobrain, Atorvastatin Rescued Chemobrain with Enhanced Anticancer Effect and without Hair Loss-Side Effect

15 citations , February 2019 in “Journal of clinical medicine”

Atorvastatin reversed memory problems caused by cancer drug trastuzumab and improved its cancer-fighting abilities without causing hair loss.

research Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation and Pigmentation Revealed by Molecular Profiling

9 citations , May 2012 in “PLOS ONE”

ILK is essential for skin development, pigmentation, and healing.

research Overexpression of hypoxia-inducible factor-1α in hidradenitis suppurativa: the link between deviated immunity and metabolism

5 citations , March 2023 in “Archives of dermatological research”

Increased HIF-1α is linked to the inflammation and severity of hidradenitis suppurativa, suggesting treatments that lower HIF-1α could help.

EDA and EDAR Expression at Different Stages of Hair Follicle Development in Cashmere Goats and Effects on Expression of Related Genes

research EDA and EDAR expression at different stages of hair follicle development in cashmere goats and effects on expression of related genes

12 citations , December 2020 in “Archives animal breeding/Archiv für Tierzucht”

EDA and EDAR are important for hair follicle development in cashmere goats and affect other related genes.

research Genomewide differential expression profiling of long non-coding RNAs in androgenetic alopecia in a Chinese male population

11 citations , April 2017 in “Journal of The European Academy of Dermatology and Venereology”

Found different long non-coding RNAs in balding Chinese men, which may help create new treatments.

Chondrogenic Differentiation of Human Scalp Adipose-Derived Stem Cells in Polycaprolactone Scaffold Using Freeze Thaw Freeze Method

research Chondrogenic differentiation of human scalp adipose‐derived stem cells in Polycaprolactone scaffold and using Freeze Thaw Freeze method

6 citations , January 2018 in “Journal of Cellular Physiology”

Human scalp fat stem cells showed improved cartilage-like development on a special scaffold with freeze-thaw treatment.

research Gene Expression of Osteopontin in Alopecia Areata? A Case-Controlled Study

1 citations , October 2014 in “Skin Pharmacology and Physiology”

People with alopecia areata have higher levels of osteopontin, which might be important in the disease's development, but this doesn't relate to how severe the disease is.

Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

research Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

91 citations , May 2003 in “American Journal of Pathology”

Prolactin affects hair growth cycles and can cause early hair follicle regression.

L-(+)-Tartaric Acid Minimally Affects Viability or Molecular Signature but Increases Expression of Selected Hair Growth-Associated Genes in Human Dermal Papilla Cells

research L-(+)-Tartaric Acid Minimally Affects the Viability or Molecular Signature but Increase the Expression of Selected Hair Growth Associated Genes in Human Dermal Papilla Cells

January 2021 in “Journal of cosmetology & trichology”

L-(+)-Tartaric Acid may help increase certain hair growth genes without harming cells.

Analysis of the Expression Pattern of the Carrier Protein Transthyretin and Its Receptor Megalin in the Human Scalp Skin and Hair Follicles: Hair Cycle-Associated Changes

research Analysis of the expression pattern of the carrier protein transthyretin and its receptor megalin in the human scalp skin and hair follicles: hair cycle-associated changes

6 citations , November 2010 in “Histochemistry and cell biology”

The proteins transthyretin and megalin are more present in the growth phase of hair, suggesting they might affect hair health and growth.