8 citations
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October 2019 in “The Journal of surgical research/Journal of surgical research” Sodium valproate helps skin healing by affecting GABA and histone deacetylase.
1 citations
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January 2019 in “Elsevier eBooks” New scaffold materials help heal severe skin wounds and improve skin regeneration.
578 citations
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April 1993 in “Cell” TGFα gene mutation in mice causes abnormal skin, wavy hair, curly whiskers, and sometimes eye inflammation.
471 citations
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October 2012 in “Cellular and Molecular Life Sciences” Understanding developmental pathways can improve wound healing treatments.
353 citations
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November 2014 in “Molecular immunology” Porcine skin is very similar to human skin, making it a useful model for research.
291 citations
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April 2010 in “Gastroenterology” Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.
289 citations
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May 2003 in “Journal of Investigative Dermatology” Human skin can produce steroids from cholesterol.
286 citations
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June 2012 in “Nature Immunology” Hair follicles help attract immune cells to the skin during stress.
256 citations
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October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Growing human skin cells in a 3D environment can stimulate new hair growth.
202 citations
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June 2005 in “Aaps Pharmscitech” Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.
162 citations
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August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” The new "differential stripping" method effectively measures how much substance gets into hair follicles.
146 citations
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January 2004 in “Hormones” Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.
113 citations
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June 2019 in “F1000Research” Scarless healing is complex and influenced by genetics and environment, while better understanding could improve scar treatment.
101 citations
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December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists turned mouse stem cells into skin cells that can grow into skin layers and structures.
99 citations
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January 2002 in “Plastic & Reconstructive Surgery” Fetal rat wounds heal without scars at 16.5 days gestation.
95 citations
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July 2010 in “Genes & development” Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.
86 citations
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April 2009 in “Journal of anatomy” Hard skin features like scales, feathers, and hair evolved through specific protein changes in different animal groups.
81 citations
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February 2014 in “EMBO molecular medicine” Activating Nrf2 in skin cells causes skin disease similar to chloracne in mice.
73 citations
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August 2019 in “Cell Proliferation” Human skin models are essential for studying skin's sensory, immune, and nervous system interactions.
69 citations
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August 1999 in “Developmental biology” The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.
69 citations
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May 1997 in “Veterinary Pathology” The angora mouse mutation causes long hair and hair defects due to a gene deletion.
68 citations
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September 2003 in “British Journal of Dermatology” Shrinking skin cancer increases the chance of cancer in nearby lymph nodes.
66 citations
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May 2012 in “Scientific Reports” Scientists successfully created and transplanted bioengineered hair follicles that function like natural ones, suggesting a new treatment for hair loss.
64 citations
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January 1998 in “Drugs” Dienogest combined with ethinylestradiol is a highly effective birth control that improves menstrual symptoms and has manageable side effects.
60 citations
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June 1997 in “Journal of The American Academy of Dermatology” Apoptosis is crucial for healthy skin and treating skin diseases.
58 citations
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June 2006 in “Plastic and Reconstructive Surgery” Mice healed without scars as fetuses but developed scars as adults, suggesting scarless healing might be replicated with further research.
51 citations
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August 2013 in “Journal of Investigative Dermatology” Human skin cells can create new hair follicles when transplanted into mice.
50 citations
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December 2017 in “British Journal of Dermatology” Different skin cells produce unique materials, which can improve skin substitutes for healing.
50 citations
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February 2004 in “Genomics” A gene mutation causes lanceolate hair in rats by disrupting hair shaft integrity.
48 citations
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June 2000 in “Japanese Journal of Cancer Research” Dimethylarsinic acid speeds up skin tumor growth in certain mice.