research A proposal for a new design: the exposure–crossover design
The "exposure–crossover design" helps assess individual changes in risk after events like car crashes.
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360-390 / 1000+ resultsresearch Alopecia areata treatment with baricitinib: different relapse phenotypes
Baricitinib can lead to hair regrowth in alopecia areata but may also cause relapses.
research ASSESSMENT OF THE FUNCTIONAL STATE OF THE RESPIRATORY SYSTEM AFTER RECOVERING FROM VIRAL INFECTION IN CHILDREN
Children may have lingering respiratory issues after recovering from COVID-19.
research Early post-natal neuroactive steroid manipulation modulates ondansetron effects on initial periods of alcohol consumption in rats
Early changes in brain chemicals affect how a drug reduces alcohol intake in rats.
research Health consequences of anabolic steroids: a sexual-medicine perspective
Anabolic steroid abuse can cause sexual, fertility, and health problems.
research Can we identify a post‐Serenoa syndrome (PSS)? A case series on sexual and psychiatric side effects of Serenoa repens
Serenoa repens may cause long-lasting sexual and psychiatric side effects.
research Interaction between early postnatal neurosteroid manipulations and adult infusion of neurosteroids into CA1 hippocampal region on the open field behaviour
Early neurosteroid changes can alter adult brain function and behavior.
research The prescribing cascade 3.0: a case for recreational drugs in HIV
Recreational drug use can cause misdiagnosed conditions and drug interactions in HIV patients.
research Nocebo effect in Dermatology
Negative expectations can cause adverse effects in dermatology treatments, like with finasteride for baldness, and careful communication can help reduce these nocebo responses.
research The effects of acute finasteride treatment in dopamine transporter knockout mice and MK-801-treated mice
research CUTANEOUS SIDE-EFFECTS OF BETA-ADRENERGIC BLOCKERS
Beta-blockers can cause rare skin side-effects, which usually improve after stopping the medication.
research How to Select Pharmacologic Treatments to Manage Recidivism Risk in Sex Offenders: Consider Patient Factors When Choosing Off-Label Hormonal and Nonhormonal Agents
Choose treatments for sex offenders based on individual needs, using hormonal and nonhormonal options to reduce sexual drive.
research Different synaptic stimulation patterns influence the local androgenic and estrogenic neurosteroid availability triggering hippocampal synaptic plasticity in the male rat
The availability of certain hormones and specific stimulation patterns affect long-term synaptic changes in the male rat brain.
research News & Notes
Loop diuretics may double bone loss in elderly men, finasteride lowers prostate cancer risk but may increase high-grade tumors, abarelix reduces testosterone quickly, and transdermal testosterone offers minimal sexual benefit for women.
research Induction and reversal of pulmonary lipid histiocytosis in rats following oral administration of anorectics cloforex and chlorphentermine
Rats developed lung issues from the drugs, but these cleared quickly after stopping them.
research Symptom Trajectories and Long-Term Sequelae of COVID-19: A Matched Case–Control Study with Population-Based Controls
COVID-19 can cause long-lasting non-respiratory symptoms, especially in women.
research Peer Review #3 of "Computational drug repositioning based on side-effects mined from social media (v0.1)"
Reviewers criticized the study for assuming drugs with similar side-effects work the same way and questioned the validity of its findings due to potential biases and data quality issues.
research Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats
Allopregnanolone can reduce gut inflammation and normalize neurotransmitter levels after finasteride withdrawal.
research Persistent Sexual and Psychological Symptoms After Finasteride Discontinuation: A Cross-Sectional Observational Study
Stopping finasteride can lead to lasting sexual and psychological issues.
research CARACTERIZAÇÃO DE SEQUELAS RELATADAS PELOS USUÁRIOS DO SUS RECUPERADOS DO COVID-19 EM UM BAIRRO DO MUNICÍPIO DA SERRA CATARINENSE
Many recovered COVID-19 patients, especially women, experience lingering symptoms like fatigue and headaches.
research The Impact of Glucagon-like Peptide-1 Receptor Agonists on Erectile Function: Friend or Foe?
The effect of GLP-1 RAs on erectile function is unclear and needs more research.
research The Acute Anticonvulsant Effects of Deoxycorticosterone in Developing Rats: Role of Metabolites and Mineralocorticoid‐receptor Responses
Deoxycorticosterone and its metabolites help prevent seizures by interacting with specific receptors.
research Comment on Current Investigations into the Postfinasteride Syndrome
Finasteride is effective for hair regrowth, but some believe it may cause persistent symptoms due to psychological factors.
research Empirical evidence of observer bias in randomized clinical trials: updated and expanded analysis of trials with both blinded and non-blinded outcome assessors
Non-blinded assessors tend to overestimate effects in trials by about 29%.
research Health Warnings Can Boost Sales: Regulators Beware
Health warnings can increase product sales over time.
research Reminder of finasteride-related psychiatric AEs and sexual dysfunction
research Sex hormone supplementation improves breathing and restores respiratory neuroplasticity following C2 hemisection in rats
Sex hormone supplements help improve breathing and nerve recovery after spinal injury in rats.
research Allopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models
Stress worsens Tourette symptoms by increasing allopregnanolone levels.
research Changes in expression of the δ subunit of the GABAAreceptor and in receptor function induced by progesterone exposure and withdrawal
Progesterone affects GABAA receptor function by altering δ subunit levels.
research The post-finasteride syndrome: possible etiological mechanisms and symptoms
Post-finasteride syndrome causes lasting sexual, mental, and physical issues, needing more research for solutions.