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GlossaryRNA-induced silencing complex

molecular machine that regulates gene expression by degrading mRNA

The RNA-induced silencing complex (RISC) is a molecular machine within cells that plays a crucial role in gene regulation. It uses small RNA molecules, such as microRNAs (miRNAs) or small interfering RNAs (siRNAs), to identify and bind to specific messenger RNA (mRNA) sequences, leading to the degradation of the mRNA or the inhibition of its translation into proteins. This process is essential for controlling gene expression and maintaining cellular function.

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T-Cell Induced-Self MHC Class I/Peptide Complexes May Enable De Novo Tolerance Induction to Neo-Antigens Occurring Outside of the Thymus

research T-cell “induced-self” MHC class I/peptide complexes may enable “de novo” tolerance induction to neo-antigens occurring outside of the thymus

8 citations , October 2016 in “Experimental dermatology”

Hair follicles may help teach the immune system to tolerate new self-antigens, but this can sometimes cause hair loss.

research Use of genetics in the prediction of success in male pattern hair loss therapy and mechanistic studies

February 2026 in “Frontiers in Pharmacology”

Genetics can help tailor treatments for male pattern hair loss, improving outcomes like stabilization or modest regrowth.

research Keratin disorders: from gene to therapy

109 citations , September 2011 in “Human molecular genetics online/Human molecular genetics”

New treatments targeting specific genes show promise for treating keratin disorders.

research The circular RNA circNlgnmediates doxorubicin-inducedcardiac remodeling and fibrosis

19 citations , March 2022 in “Molecular therapy. Nucleic acids”

A specific RNA, circNlgn, contributes to heart damage and scarring caused by the cancer drug doxorubicin.

research Specific inhibition of FGF5-induced cell proliferation by RNA aptamers

15 citations , February 2021 in “Scientific Reports”

RNA aptamers can specifically block FGF5-related cell growth, potentially treating related diseases or hair disorders.

research 944 Non-coding double stranded RNA induces retinoic acid synthesis and retinoid signaling to control regeneration

April 2019 in “Journal of Investigative Dermatology”

Non-coding RNA boosts retinoic acid production and signaling, aiding regeneration.

research Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75

6 citations , September 2015 in “Journal of Investigative Dermatology”

Using special RNA to target a mutant gene fixed hair problems in mice.

Epidermal Stem Cells Are Defined by Global Histone Modifications Altered by Myc-Induced Differentiation

research Epidermal Stem Cells Are Defined by Global Histone Modifications that Are Altered by Myc-Induced Differentiation

98 citations , August 2007 in “PLoS ONE”

Myc changes chromatin in stem cells, causing them to leave their niche.

research From gene to therapy in spinal and bulbar muscular atrophy: Are we there yet?

17 citations , July 2017 in “Molecular and Cellular Endocrinology”

Effective treatments for spinal and bulbar muscular atrophy are not yet available; more research is needed.

research An Overview of Alopecias

53 citations , March 2014 in “Cold Spring Harbor Perspectives in Medicine”

The document explains different types of hair loss, their causes, and treatments, and suggests future research areas.

research Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage

101 citations , December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Scientists turned mouse stem cells into skin cells that can grow into skin layers and structures.

research Identification of key genes induced by platelet-rich plasma in human dermal papilla cells using bioinformatics methods

16 citations , December 2016 in “Molecular Medicine Reports”

Platelet-rich plasma may help hair follicle cells grow by affecting certain genes and pathways.

research Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin cells and certain hair follicle areas produce hemoglobin, which may help protect against oxidative stress like UV damage.

Skin Regeneration: Strategies and Innovations

research Skin Regeneration

January 2016 in “Springer eBooks”

New materials and methods could improve skin healing and reduce scarring.

research Oncogenic senescence: a multi-functional perspective

32 citations , February 2017 in “Oncotarget”

Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.

research Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after wounding

28 citations , October 2019 in “Seminars in Cell & Developmental Biology”

Hair can regrow in large wounds through a process similar to how hair forms in embryos, and understanding this could lead to new treatments for hair loss or scarring.

research Knockout of p16INK4a promotes aggregative growth of dermal papilla cells

2 citations , October 2017 in “Revista Da Associacao Medica Brasileira”

Removing p16INK4a from skin cells can lead to faster and more clumped growth, which might help with hair growth.

Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

research Pharmacological Activation of Thermo–Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

12 citations , June 2019 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics”

Activating TRPV3 channels stops hair growth by killing hair follicle cells.

Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

research Human epithelial hair follicle stem cells and their progeny: Current state of knowledge, the widening gap in translational research and future challenges

106 citations , March 2014 in “BioEssays”

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

research TMPRSS2: A Key Host Factor in SARS-CoV-2 Infection and Potential Therapeutic Target

4 citations , June 2025 in “Medeniyet Medical Journal”

TMPRSS2 is crucial for COVID-19 infection and is a potential target for treatment.

research TGF-β family signaling in stem cells

132 citations , August 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects”

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

research Regulation of somatic cell reprogramming through inducible mir-302 expression

308 citations , September 2010 in “Nucleic acids research”

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

LncRNA-599547 Contributes to the Inductive Property of Dermal Papilla Cells in Cashmere Goats Through miR-15b-5p/Wnt10b Axis

research LncRNA-599547 contributes the inductive property of dermal papilla cells in cashmere goat through miR-15b-5p/Wnt10b axis

7 citations , August 2020 in “Animal biotechnology”

A specific RNA in cashmere goats helps improve hair growth by interacting with certain molecules.

research miR-29a-5p Inhibits Prenatal Hair Placode Formation Through Targeting EDAR by ceRNA Regulatory Network

May 2022 in “Frontiers in Cell and Developmental Biology”

miR-29a-5p prevents the formation of early hair structures by targeting a gene important for hair growth and is regulated by a complex network involving lncRNA627.1.