research Phosphodiesterase inhibitors and prostaglandin analogues in dermatology: A comprehensive review
Certain drugs are effective for skin conditions like psoriasis, vitiligo, and hair loss.
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research SELF-ASSEMBLED CHITOSAN NANOPARTICLES FOR PERCUTANEOUS DELIVERY OF CAFFEINE: PREPARATION, CHARACTERIZATION AND IN VITRO RELEASE STUDIES
Chitosan nanoparticles are promising for sustained caffeine delivery through the skin.
research An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic Syndrome
Abnormal growth factor metabolism may link psoriasis and metabolic syndrome, and obesity can affect psoriasis treatment effectiveness.
research A Review of the Characteristics of Clinical Trials and Potential Medications for Alcohol Dependence: Data Analysis from ClinicalTrials.gov
No medications for alcohol dependence have been approved for marketing yet.
research JAK Inhibitors in the Treatment of Alopecia Areata: Efficacy, Safety, and Long-term Outcomes
JAK inhibitors can effectively regrow hair in alopecia areata patients, but ongoing treatment is needed to maintain results.
research Drug-Loaded Extracellular Vesicle-Based Drug Delivery: Advances, Loading Strategies, Therapeutic Applications, and Clinical Challenges
EV-based drug delivery shows promise but faces challenges in standardization and scalability.
research Platelet-rich plasma as a potential treatment for noncicatricial alopecias
Platelet-rich plasma, which carries growth factors, could be a promising treatment for non-scarring hair loss, promoting hair growth and density with no major side effects.
research NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium
NFAT5 triggers atherosclerosis under stress by activating inflammation in blood vessels.
research 67 Patterns of clinical response in patients with alopecia areata (AA) treated with ritlecitinib in the ALLEGRO phase 2b/3 and ongoing, phase 3, ALLEGRO-LT studies
This post-hoc analysis examined the response patterns of 191 patients with alopecia areata (AA) treated with ritlecitinib in the ALLEGRO phase 2b/3 and ALLEGRO-LT studies. Patients aged ≥12 years with ≥50% hair loss were categorized based on their Severity of Alopecia Tool (SALT) score trajectories over 96 weeks. Results showed that 45.5% of patients were responders, with 18.3% responding early, 16.8% in the middle period, and 10.5% late. Additionally, 12.6% were partial responders, 29.3% were non-responders, and 12.6% were relapsers. Factors such as female sex, younger age, absence of active shedding, shorter duration of scalp hair loss, and lower baseline SALT score were linked to a higher likelihood of response. The study suggests that over 45% of patients benefit from ritlecitinib, with most responding within 1 year, although some may require extended treatment.
research Absence of Heart Failure in Severe Cardiac and Autonomic Amyloidosis: The Essential Role of Sympathetic Activation and Venous Tone in the Development of the Congestive Heart Failure Syndrome
Sympathetic activation and venous tone are crucial for heart failure symptoms.
research A Profuse Pipeline of Promising Options
The document concludes that significant investment in agricultural innovation is necessary to achieve global food security and nutrition.
research Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway
The gene NM_026333 slows down aging by affecting the NCX1 pathway and could be targeted for anti-aging treatments.
research Intralesional methotrexate in patchy alopecia areata: trichoscopic evaluation and effect on lesional tumour necrosis factor alpha
Intralesional methotrexate effectively treats patchy alopecia areata by reducing inflammation.
research COMMENTS ON THE LETTER ON HYPONATREMIA ASSOCIATED WITH DIURETIC USE AND URINARY RETENTION IN AN OLDER MAN
Older adults on certain medications should be carefully monitored for urinary issues and low sodium levels.
research Granulomatous Alopecia Areata: A Rare Report With a Review
Granulomatous Alopecia Areata is rare and may be caused by hair antigens or follicle destruction.
research Wiederbehaarung bei einem Patienten mit Alopecia universalis und Psoriasis vulgaris unter Deucravacitinib‐Therapie
Deucravacitinib helped a man regrow hair and improve psoriasis.
research Is the severity of alopecia areata associated with arterial stiffness?
Severe alopecia areata may increase the risk of heart-related diseases.
research The Relative Efficacy and Safety of Monotherapies for Alopecia Areata: A Network Meta‐Analysis Study
Janus kinase inhibitors are effective and safe for treating Alopecia Areata.
research Efficacy of Local and Whole‐Body Phototherapy for the Treatment of Various Types of Alopecia Areata
Phototherapy effectively treats certain alopecia areata types, especially if started early.
research Case Report of a Patient With Psoriasis Vulgaris, Psoriatic Arthritis and Alopecia Universalis Successfully Treated With Tofacitinib and Methotrexate
Tofacitinib and methotrexate successfully treated a woman's severe skin, joint, and hair loss issues.
research Interleukin 15 Gene Polymorphism in patients with Alopecia Areata
Targeting IL-15 may help treat Alopecia Areata.
research Effectiveness and Safety Profile of Oral Tofacitinib in Alopecia Areata: An Observational Study from a Tertiary Hospital
This observational study assessed the effectiveness and safety of oral tofacitinib in 30 patients with alopecia areata over 18 months. Results showed significant hair regrowth, with most patients experiencing a >50% reduction in the Severity of Alopecia Tool (SALT) score at 3 and 6 months. The treatment was generally well-tolerated, with mild side effects such as raised liver enzymes and acne. The study concluded that tofacitinib is a promising treatment for alopecia areata, though further research with larger sample sizes and longer follow-up is recommended to evaluate long-term efficacy and relapse rates.
research Approach to Nail Pitting in Pediatric and Adolescent Patients: A Dermatology Perspective
Nail pitting in kids can be harmless or indicate other health issues, so thorough evaluation is crucial.
research Insights into the Diagnostics and Therapeutics of Alopecia Areata—An Indian Context
Improved diagnosis and affordable topical treatments are essential for managing alopecia areata in India.
research Revisión y avances en tricología
Recent advancements in hair loss treatments include new therapies and insights for different types of alopecia.
research INTEGRATIVE APPROACH TO KHALITYA: BRIDGING AYURVEDA AND MODERN SCIENCE
Dietary habits and stress management are key to preventing hair loss.
research INTEGRATIVE APPROACH TO KHALITYA: BRIDGING AYURVEDA AND MODERN SCIENCE
Dietary habits and stress management are key to preventing hair loss.
research Minoxidil/salicylic acid hydrogel formulated for alopecia treatment: Supramolecular interactions modulate physicochemical properties and biological activities revealed by experimental and theoretical studies
The new minoxidil and salicylic acid hydrogel improves alopecia treatment.
research Evaluation of the Efficacy and Safety of Oral Tofacitinib for the Treatment of Alopecia Areata in Children
Tofacitinib effectively reduces hair loss in children with alopecia areata but may cause mild side effects and relapses.
research Ann Robinson’s research reviews —12 May 2022
Self-monitoring blood pressure in pregnant women didn't improve outcomes, diabetes drugs may increase gallbladder disease risk, a new drug helps severe hair loss, a plant-based COVID-19 vaccine is 69.5% effective, and new anticoagulants are safer for diabetics with heart rhythm issues than warfarin.