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Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

research Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

40 citations , December 2012 in “PLoS ONE”

The study explored the role of Ctip2/Bcl11b in epidermal keratinocytes by selectively deleting it in adult mice, leading to atopic dermatitis-like skin inflammation characterized by alopecia, pruritus, and immune cell infiltration. The absence of Ctip2 resulted in increased expression of Th2-type cytokines and chemokines, such as TSLP, CCL17, IL13, and IL4, which are crucial in inflammatory skin diseases. The findings highlighted Ctip2's essential role in maintaining skin barrier function and suppressing inflammatory responses, suggesting its potential involvement in atopic dermatitis pathogenesis and providing a model for further research into therapeutic strategies.

Normal Fur Development and Sebum Production Depend on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands

research Normal Fur Development and Sebum Production Depends on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands

40 citations , June 2011 in “Journal of biological chemistry/The Journal of biological chemistry”

FA2H is essential for normal fur and sebum production in mice.

research Gene Expression of Mouse S100A3, a Cysteine-Rich Calcium-Binding Protein, in Developing Hair Follicle

40 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

S100A3 protein is crucial for hair shaft formation in mice.

research A dopamine-methacrylated hyaluronic acid hydrogel as an effective carrier for stem cells in skin regeneration therapy

39 citations , August 2022 in “Cell Death and Disease”

DA-MeHA hydrogel effectively aids stem cell-based skin regeneration.

Adipose Mesenchymal Stem Cells Combined with Platelet-Rich Plasma Accelerate Diabetic Wound Healing by Modulating the Notch Pathway

research Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway

39 citations , July 2021 in “Stem Cell Research & Therapy”

Using fat stem cells and blood cell-rich plasma together improves healing in diabetic wounds by affecting cell signaling.

Combination of Herbal Extracts and Platelet-Rich Plasma Induced Dermal Papilla Cell Proliferation: Involvement of ERK and Akt Pathways

research Combination of herbal extracts and platelet-rich plasma induced dermal papilla cell proliferation: involvement of ERK and Akt pathways

39 citations , June 2013 in “Journal of Cosmetic Dermatology”

Herbal extracts and platelet-rich plasma together may help increase hair growth by making certain cells grow more, through specific cell growth pathways.

research Common variants in the sex hormone-binding globulin gene (SHBG) and polycystic ovary syndrome (PCOS) in Mediterranean women

39 citations , September 2012 in “Human Reproduction”

Certain genetic variations in the SHBG gene are linked to an increased or decreased risk of PCOS in Mediterranean women.

GLI2-Specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells

research GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells

39 citations , March 2008 in “Journal of biological chemistry/The Journal of biological chemistry”

GLI2 increases follistatin production in human skin cells.

research The effect of tripeptide-copper complex on human hair growth in vitro

39 citations , July 2007 in “Archives of Pharmacal Research”

A tripeptide-copper complex may help hair grow by increasing cell growth and decreasing cell death.

research Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity

38 citations , July 2019 in “Nature Communications”

Par3 protein is essential for skin cell balance and stability.

Knock-Down of Arabidopsis PLC5 Reduces Primary Root Growth and Secondary Root Formation While Overexpression Improves Drought Tolerance and Causes Stunted Root Hair Growth

research Knock-Down of Arabidopsis PLC5 Reduces Primary Root Growth and Secondary Root Formation While Overexpression Improves Drought Tolerance and Causes Stunted Root Hair Growth

38 citations , June 2018 in “Plant & cell physiology/Plant and cell physiology”

Changing the amount of PLC5 in Arabidopsis affects root growth and drought resistance, with less PLC5 slowing root growth and more PLC5 improving drought tolerance but hindering root hair growth.

Proteomic Tools for the Investigation of Human Hair Structural Proteins and Evidence of Weakness Sites on Hair Keratin Coil Segments

research Proteomic tools for the investigation of human hair structural proteins and evidence of weakness sites on hair keratin coil segments

38 citations , October 2011 in “Analytical biochemistry”

Hair proteins have weak spots in their α-helical segments.

Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor

research Lymphoid Enhancer-binding Factor-1 (LEF1) Interacts with the DNA-binding Domain of the Vitamin D Receptor

37 citations , April 2011 in “Journal of Biological Chemistry”

LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.

research Glucagon-like peptide-1 receptor and proglucagon expression in mouse skin

37 citations , March 2006 in “Regulatory Peptides”

Mice skin has components that could help with hair growth and might be used for diabetes treatment.

WISP-1 Induced by Mechanical Stress Contributes to Fibrosis and Hypertrophy of the Ligamentum Flavum Through Hedgehog-Gli1 Signaling

research WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling

36 citations , June 2021 in “Experimental & Molecular Medicine”

Targeting Hedgehog signaling may help treat ligamentum flavum fibrosis.

Convergent Evolution of Cysteine-Rich Keratins in Hard Skin Appendages of Terrestrial Vertebrates

research Higher PDCD4 expression is associated with obesity, insulin resistance, lipid metabolism disorders, and granulosa cell apoptosis in polycystic ovary syndrome

34 citations , February 2016 in “Fertility and Sterility”

More PDCD4 is linked to obesity, insulin problems, and cell death in ovaries for those with polycystic ovary syndrome.

Curcuma Aeruginosa, A Novel Botanically Derived 5α-Reductase Inhibitor In The Treatment Of Male-Pattern Baldness: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study

research Curcuma aeruginosa, a novel botanically derived 5α-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study

34 citations , July 2011 in “Journal of Dermatological Treatment”

Curcuma aeruginosa extract combined with minoxidil effectively treats male-pattern baldness.

research Regulation of VDR by ΔNp63α is associated with inhibition of cell invasion

34 citations , July 2009 in “Journal of Cell Science”

ΔNp63α helps control a protein that stops cancer cells from spreading.

research Molecular characterization of xerosis cutis: A systematic review

33 citations , December 2021 in “PLoS ONE”

It's unclear which molecules best characterize dry skin due to inconsistent findings.

Hair Regenerative Mechanisms of Red Ginseng Oil and Its Major Components in the Testosterone-Induced Delay of Anagen Entry in C57BL/6 Mice

research Hair Regenerative Mechanisms of Red Ginseng Oil and Its Major Components in the Testosterone-Induced Delay of Anagen Entry in C57BL/6 Mice

33 citations , September 2017 in “Molecules”

Red ginseng oil and its components help promote hair regrowth and could treat hair loss.

Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways

research Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways

33 citations , January 2017 in “Annals of Dermatology”

LED light can help hair growth by activating specific cell pathways.

Cell Wall-Associated Root Hair Specific 10, a Proline-Rich Receptor-Like Kinase, Is a Negative Modulator of Arabidopsis Root Hair Growth

research Cell wall-associated ROOT HAIR SPECIFIC 10, a proline-rich receptor-like kinase, is a negative modulator of Arabidopsis root hair growth

33 citations , February 2016 in “Journal of Experimental Botany”

ROOT HAIR SPECIFIC 10 (RHS10) reduces the length of root hairs in Arabidopsis plants.

Parathyroid Hormone-Related Protein and the PTH Receptor Regulate Angiogenesis of the Skin

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