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January 2010 Finasteride is mainly broken down by the enzyme CYP3A4, affecting its levels in the body.
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November 2008 in “European Journal of Pharmaceutical Sciences” St. John's wort increases finasteride metabolism, reducing its effectiveness; use caution when combining them.
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St. John’s wort changes how finasteride works in the body, possibly affecting its effectiveness.
Finasteride's metabolites were identified, helping understand how the drug is processed in the body.
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March 2020 in “Frontiers in Neuroendocrinology” The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.
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