research Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signalling pathways
Hair loss involves immune responses, inflammation, and disrupted signaling pathways.
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510-540 / 1000+ results research Circ 0020938 inhibits hair follicle stem cells proliferation via the miR-142-5p/DSG4 axis in cashmere goats
Circ 0020938 slows down hair growth in cashmere goats.
research Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.
research Targeting integrin pathways: mechanisms and advances in therapy
New therapies are being developed that target integrin pathways to treat various diseases.
research MiR-23b and miR-133 cotarget TGFβ2/NOTCH1 in dermal fibroblasts and affect hair follicle development in sheep
Two microRNAs affect hair follicle development in sheep by targeting specific genes.
research The AR/miR-221/IGF-1 pathway mediates the pathogenesis of androgenetic alopecia
A specific pathway involving AR, miR-221, and IGF-1 plays a key role in causing common hair loss.
research Developmental signals in skin morphogenesis
Key signals like Wnt and β-catenin are crucial for skin and hair development, with potential for treating skin disorders.
research Impaired Lef1 activation accelerates iPSC-derived keratinocytes differentiation in Hutchinson-Gilford Progeria Syndrome
Impaired LEF1 activation speeds up skin cell development in Hutchinson-Gilford Progeria Syndrome.
research Beyond Wavy Hairs
EGFR signaling is crucial for skin and hair health, and targeting it could help treat skin diseases and cancer.
research Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege
A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.
research Chaperones as thermodynamic sensors
New cancer treatments show promise in reducing tumor growth and improving skin regeneration in mice.
research Glutamate transporter Slc1a3 mediates inter‐niche stem cell activation during skin growth
The protein SLC1A3 is important for activating skin stem cells and is necessary for normal hair and skin growth in mice.
research Single-cell analysis of basal cell carcinoma reveals heat shock proteins promote tumor growth in response to WNT5A-mediated inflammatory signals
Heat shock proteins help basal cell carcinoma grow by responding to inflammation signals.
research The role of lipids in promoting hair growth through HIF-1 signaling pathway
Lipids may help treat hair loss by promoting hair growth through the HIF-1 pathway.
research A hairy kinase
Sgk3 kinase is essential for normal hair growth in mice.
research Author response: Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta
Sphingosine 1-phosphate affects inflammation and gene expression in different aorta cells.
research Signalling Underlying Wound Healing
Wound healing involves complex signaling that stops bleeding, reduces damage, and repairs skin, sometimes without scarring.
research Wnt/β-catenin and ERK pathway activation: The possible mechanism of various light-emitting diode light regulates the proliferation of human outer root sheath cells
LED light helps human hair root cells grow and move by activating certain cell pathways.
research PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration
PI3K/Akt pathway is crucial for hair growth and regeneration.
research Expression of truncated latent TGF-β-binding protein modulates TGF-β signaling
Truncated LTBP-1 disrupts TGF-β signaling, affecting hair growth.
research 613 Bacteria induce skin regeneration via IL-1β signaling
Bacteria can help skin regenerate through a process called IL-1β signaling.
research MiR-325-3p functions as a suppressor miRNA and inhibits the proliferation and metastasis of glioma through targeting FOXM1
miR-325-3p can slow down brain tumor growth by targeting FOXM1.
research Hairless Up‐Regulates Tgf‐β2 Expression via Down‐Regulation of miR‐31 in the Skin of “Hairpoor” (HrHp) Mice
HR protein causes abnormal hair cycles by increasing Tgf-β2 and reducing miR-31.
research Role of ASLNC168501 in regulating hair follicle stem cell activity via the AR/miR-128-3p/IGF-1 pathway
ASLNC168501 may help treat hair loss by boosting hair follicle stem cell activity.
research Therapeutic Potential of Secretome from Hypoxic-Mesenchymal Stem Cell (SH-MSC) in Regulating PDGF and IL-1β Gene Expression in Fluconazole-Related Alopecia
SH-MSCs can improve hair growth by balancing gene expressions in fluconazole-related hair loss.
research RAGE and Its Ligands in Melanoma
RAGE is a potential target for melanoma treatment, but its effectiveness is uncertain due to variable expression levels.
research Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
IL-1 promotes fat cell growth in skin, while WNT inhibits it and encourages scar formation.
research Optogenetically Controlled TrkA Activity Improves the Regenerative Capacity of Hair‐Follicle‐Derived Stem Cells to Differentiate into Neurons and Glia
Blue-light activation of TrkA improves hair-follicle stem cells' ability to become neurons and glial cells.
research 132 Design of an in vitro skin 3D model mimicking a disruption of the barrier function
Activating the hexosamine pathway can improve skin health and increase hair follicle stem cells.
research The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds
Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.