Search

for
Search:

Did you mean Signaling Pathways?

GlossarySignaling Pathways

series of molecular interactions transmitting signals within cells

Signaling pathways, also known as signal transduction pathways or cell signaling pathways, are a series of molecular interactions that transmit signals from a cell's exterior to its interior, leading to a specific cellular response. These pathways involve receptors, enzymes, and other proteins that work together to regulate various biological processes, such as cell growth, differentiation, and apoptosis. Understanding these pathways is crucial for developing treatments for conditions like cancer and alopecia, where signaling disruptions can lead to disease.

Related Terms

Sort by

Research

30 / 1000+ results

An Analysis of Gene Expression Data Involving Examination of Signaling Pathways Activation Reveals New Insights into the Mechanism of Action of Minoxidil Topical Foam in Men with Androgenetic Alopecia

research An analysis of gene expression data involving examination of signaling pathways activation reveals new insights into the mechanism of action of minoxidil topical foam in men with androgenetic alopecia

12 citations , June 2017 in “Cell Cycle”

Minoxidil foam helps hair growth by increasing good proteins and decreasing bad pathways in men with hair loss.

Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells

research Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells

3 citations , February 2022 in “Frontiers in Genetics”

The LncRNA AC010789.1 slows down hair loss by promoting hair follicle growth and interacting with miR-21 and the Wnt/β-catenin pathway.

research Analysis of Sonic Hedgehog signalling pathway gene expression in Basal Cell Carcinoma and in GLII induced systems

January 2007 in “Queen Mary Research Online (Queen Mary University of London)”

GLI and EGF signalling affect Basal Cell Carcinoma development and could be therapeutic targets.

research Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma

15 citations , September 2014 in “PloS one”

The study found that analyzing certain cell signaling pathways is not a reliable method to tell apart two types of skin tumors.

research Identification of Key Genes and Signaling Pathways in Male Androgenetic Alopecia by Bioinformatics Analysis

July 2020 in “Bioinformatics and Bioengineering”

Found key genes affecting hair loss, immune response, and skin development; more research needed for better treatments.

research Linc-PINT downregulation of TGF-β signaling pathway in heart arrhythmia: an in silico analysis

April 2025 in “Journal of Diabetes & Metabolic Disorders”

Monitoring TGF-β and linc-PINT expression may help identify and treat high-risk heart arrhythmia patients.

research Transcriptomic analysis identifies regulators of the Wnt signalling and hypoxia-inducible factor pathways as possible mediators of androgenetic alopecia

October 2022 in “British Journal of Dermatology”

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Network Pharmacology and In Vivo Experimental Analysis for Validating the Antifibrotic Potential of Punica Granatum Leaves Against Skin Scleroderma: The Role of Oxidative Stress, Inflammation and TGF-β1/Snail 1/p-Smad 3 Signaling Pathway

research Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway

April 2026 in “Inflammopharmacology”

Punica granatum leaf extract may help treat skin fibrosis by reducing inflammation and oxidative stress.

research Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling

13 citations , September 2022 in “Biomolecules”

The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.

In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

research In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos (Anser cygnoides)

6 citations , May 2022 in “Frontiers in physiology”

Injecting CHIR-99021 into goose embryos improves feather growth by changing gene activity and energy processes.

research Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

6 citations , February 2013 in “Journal of Visualized Experiments”

The method quickly analyzes hair growth genes and shows that blocking Smo in skin cells stops hair growth.

research Differential expression of mTOR signaling pathway proteins in lichen planopilaris and frontal fibrosing alopecia

5 citations , September 2018 in “Acta histochemica”

The mTOR pathway proteins are altered in the hair follicles of patients with Lichen Planopilaris and Frontal Fibrosing Alopecia.

research Wnt/β-Catenin Signaling Pathway Targeting Androgenetic Alopecia: How Far Can We Go Beyond Minoxidil and Finasteride?

September 2025 in “Journal of Medicinal Chemistry”

Targeting the Wnt/β-catenin pathway may lead to better treatments for hair loss.

research Integrated miRNA-mRNA analysis reveals regulatory pathways underlying the curly fleece trait in Chinese tan sheep

17 citations , May 2018 in “BMC genomics”

Researchers found genes and microRNAs that control curly fleece in Chinese Tan sheep.

research Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts

9 citations , March 2019 in “Molecular & cellular proteomics”

Reductive stress messes up collagen balance and alters cell signaling in human skin cells, which could help treat certain skin diseases.

Identification of Potential Key Genes and Pathways Associated with the Pashmina Fiber Initiation Using RNA-Seq and Integrated Bioinformatics Analysis

research Identification of potential key genes and pathways associated with the Pashmina fiber initiation using RNA-Seq and integrated bioinformatics analysis

36 citations , January 2021 in “Scientific Reports”

Key genes and pathways, including Wnt, NF-Kappa, and JAK-STAT, are crucial for starting Pashmina fiber growth in goats.

Hibiscus Rosa Sinensis Linn. Petals Modulate Glycogen Metabolism and Glucose Homeostasis Signaling Pathway in Streptozotocin-Induced Experimental Diabetes

research Hibiscus rosa sinensis Linn. Petals Modulates Glycogen Metabolism and Glucose Homeostasis Signalling Pathway in Streptozotocin-Induced Experimental Diabetes

10 citations , November 2015 in “Plant Foods for Human Nutrition”

Hibiscus petals helped control blood sugar and improve liver and pancreas health in diabetic rats.

Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

research Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Re-Growth in Androgenetic Alopecia. Biomolecular Pathway Analysis and Clinical Evaluation

69 citations , April 2019 in “Biomedicines”

PRP and HF-MSCs treatment improves hair growth, thickness, and density in androgenetic alopecia.

Differential Gene Expression Analysis Between Anagen and Telogen of Capra Hircus Skin Based on the De Novo Assembled Transcriptome Sequence

research Differential gene expression analysis between anagen and telogen of Capra hircus skin based on the de novo assembled transcriptome sequence

31 citations , March 2013 in “Gene”

Signaling pathways are crucial for hair growth in goats.

research Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats

127 citations , March 2016 in “PLoS ONE”

Key genes and pathways crucial for hair follicle development in cashmere goats were identified, aiding fleece production improvement.

Proteomic Analysis of Two Stem Cell Secretomes Used in Combination in a Topical Skin Care Product Demonstrating Efficacy in a Double-Blinded, Vehicle-Controlled Clinical Trial

research Proteomic Analysis of Two Stem Cell Secretomes Used in Combination in a Topical Skin Care Product That Has Demonstrated Efficacy in a Double-Blinded, Vehicle-Controlled Clinical Trial

March 2026 in “Preprints.org”

The combined stem cell secretome in the skin care product effectively reduces inflammation and promotes tissue regeneration.

research Genome-wide detection and sequence conservation analysis of long non-coding RNA during hair follicle cycle of yak

September 2020 in “Research Square (Research Square)”

Researchers found that certain RNA sequences play a role in yak hair growth and these sequences are somewhat similar to those in cashmere goats.

research Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys cahirinus and Scarring Mus musculus

13 citations , January 2020 in “Scientific Reports”

The African spiny mouse heals skin without scarring due to different protein activity compared to the common house mouse, which heals with scarring.

research Genome-wide detection and sequence conservation analysis of long non-coding RNA during hair follicle cycle of yak

July 2020 in “Research Square (Research Square)”

The study found key long non-coding RNAs involved in yak hair growth cycles.

research Expression profile analysis of microRNAs during hair follicle development in the sheep foetus

9 citations , April 2019 in “Bioscience, biotechnology, and biochemistry”

Ten miRNAs may play key roles in starting secondary hair follicle development in sheep foetuses.

research Expression profile analysis of dermal papilla cells mRNA in response to WNT10B treatment

7 citations , December 2019 in “Experimental and Therapeutic Medicine”

WNT10B affects hair growth by altering gene activity in hair cells.

research Integrated multiomics analysis reveals the molecular features and crucial regulators of hair follicles in yak (Bos grunniens)

January 2026 in “Communications Biology”

Yak hair follicles adapt to cold through specific gene regulation, enhancing cell growth.

research Olink proteomics analysis of scalp psoriasis reveals a cytokine storm inflammatory mainly related to bacterial-derived antigens

July 2025

Scalp psoriasis inflammation is mainly caused by bacteria-related triggers.

In Silico Analysis of Gene Expression Data from Bald Frontal and Haired Occipital Scalp to Identify Candidate Genes in Male Androgenetic Alopecia

research In silico analysis of gene expression data from bald frontal and haired occipital scalp to identify candidate genes in male androgenetic alopecia

6 citations , September 2019 in “Archives of Dermatological Research”

Found 32 genes linked to male baldness, affecting hair growth and stress-related pathways.