research Beyond Expectations
Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.
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research Synergistic delivery of ginseng exosomes and biomimetic melanosomes via temporally controlled hydrogel microneedles restrain the pathologic triad of vitiligo
A new microneedle treatment can effectively repigment skin in vitiligo.
research Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatitis
Blocking certain immune signals can reduce skin damage from radiation therapy.
research Exogenous Alpha-Ketoglutaric Acid Alleviates the Rabbit Dermal Papilla Cell Oxidative Damage Caused by Hydrogen Peroxide Through the ERK/Nrf2 Signaling Pathway
Alpha-ketoglutarate protects rabbit skin cells from oxidative damage by activating a specific cell pathway.
research Obesity and Wound Healing: Focus on Mesenchymal Stem Cells
Obesity can worsen wound healing by negatively affecting the function of stem cells in fat tissue.
research Clinical and Physiological Determinants of Restorative Dermopigmentation:
Restorative dermopigmentation improves skin appearance and function by addressing specific skin issues.
research Hair Follicle Stem Cell SLC3A2 Regulates Epithelial Regenerative Properties
SLC3A2 is crucial for hair follicle stem cell function and hair growth.
research Fibroblast depletion reveals mammalian epithelial resilience across neonatal and adult stages
The skin can still regenerate and function well even with fewer fibroblasts.
research 265 Loss of Langerhans cells in scar lesion of lichen planopilaris is caused by downregulation of integrin αvβ6 in the epidermal keratinocytes
Scarred skin in lichen planopilaris loses immune cells due to a decrease in a specific protein in skin cells.
research Autoimmune Diseases and Acquired Von Willebrand Disease in Two Cases of Progeria
Premature aging increases the risk of immune problems and autoimmune diseases.
research IMMUNOPATHOLOGY OF THE HUMAN HAIR FOLLICLE
The document concludes that immune system abnormalities cause alopecia areata, but the exact process is still not completely understood.
research Regulatory T cells in skin regeneration and wound healing
Regulatory T cells help heal skin and grow hair, and their absence can lead to healing issues and hair loss.
research First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases
Thymus transplantation successfully restored immune function in infants with FOXN1 deficiency.
research IL-15 in T-Cell Responses and Immunopathogenesis
IL-15 is key for T cell function and could help improve treatments for immune-related diseases.
research Immunopathology and Immunotherapy of Inflammatory Skin Diseases
New targeted immunotherapies are improving treatment for inflammatory skin diseases.
research Novel TMEM173 Mutation and the Role of Disease Modifying Alleles
A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.
research Human adipose tissue-derived small extracellular vesicles promote soft tissue repair through modulating M1-to-M2 polarization of macrophages
Tiny fat-derived particles can help repair soft tissues by changing immune cell types.
research The Enrichment of Specific Hair Follicle-Associated Cell Populations in Plucked Hairs Offers an Opportunity to Study Gene Expression Underlying Hair Traits
Plucked hairs can be used instead of skin biopsies to study hair traits because they contain specific cells related to hair.
research Delta‐6 desaturase knockout mouse illustrates previously undocumented pathology
Lack of certain fatty acids causes skin, immune, and fertility issues in mice.
research The Mitochondrial Blueprint of Skin Aging: From Damage Signals to Dermatologic Interventions
Targeting mitochondria can improve skin health and slow aging.
research Protein S-Palmitoylation as Potential Therapeutic Target for Dermatoses
Targeting protein S-palmitoylation could lead to new skin disease treatments.
research Carcinogenesis of the Human Scalp. An Immunometabolic Centered View
Hair protects the scalp from skin cancer by aiding immune defense.
research Topical JAK Inhibitors for the Treatment of Alopecia Areata and Vitiligo
Topical JAK inhibitors can effectively treat alopecia areata and vitiligo by modulating immune responses.
research Skin microbiota and diabetic foot ulcers
Imbalanced skin bacteria worsen diabetic foot ulcers, but adjusting them might improve healing.
research Innovations in skin microphysiological systems for nonclinical testing and FDA modernization
New technologies replicate human skin for testing without animals.
research Bioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations
Bioactive glasses help heal skin wounds by promoting tissue repair and preventing infections.
research Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin® with Marilex® in Pattern Hair Loss and Telogen Effluvium
Proteoglycans are important for hair growth, and a specific treatment can help reduce hair loss.
research Hormonal interventions in skin wounds – a mini review
Hormones can improve wound healing by regulating the healing process.
research Vitiligo: are microbes to blame?
Microbes might play a role in vitiligo.
research Lipid Modulation and Systemic Inflammation
Dietary lipids affect inflammation and are crucial for normal cell function and immune health.