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GlossarySmall Interfering RNA

molecule that silences specific genes by degrading their mRNA

Small Interfering RNA (siRNA) is a type of molecule that can silence or "turn off" specific genes within a cell. It works by binding to a complementary messenger RNA (mRNA) sequence, leading to its degradation and preventing the production of the corresponding protein. This mechanism is often used in research and therapeutic applications to study gene function or to target and reduce the expression of disease-related genes.

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The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis

research The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis

3 citations , February 2022 in “Frontiers in cell and developmental biology”

A specific RNA molecule, circCOL1A1, affects the growth and quality of goat hair by interacting with miR-149-5p and influencing cell growth pathways.

research Keratin disorders: from gene to therapy

109 citations , September 2011 in “Human molecular genetics online/Human molecular genetics”

New treatments targeting specific genes show promise for treating keratin disorders.

research Advances in transdermal siRNAs delivery: A review of current research progress

20 citations , May 2023 in “Non-coding RNA Research”

New delivery systems are improving siRNA treatments for skin conditions.

research Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75

6 citations , September 2015 in “Journal of Investigative Dermatology”

Using special RNA to target a mutant gene fixed hair problems in mice.

research Efficient Silencing of Androgen Receptor Gene via UTR-Targeting siRNAs for Androgenetic Alopecia Therapy

September 2025 in “Journal of Medicinal Chemistry”

AR-27 E-Chol siRNA can effectively regrow hair by reducing androgen receptor gene activity.

research Efficient Silencingof Androgen Receptor Gene viaUTR-Targeting siRNAs for Androgenetic Alopecia Therapy

September 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

AR-27 E-Chol siRNA can effectively promote hair regrowth for androgenetic alopecia.

research Genomic Markers and Personalized Medicine in Androgenetic Alopecia: A Comprehensive Review

August 2024 in “Cosmetics”

Personalized treatments for hair loss are becoming more effective by using genetic information.

research Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia

November 2022 in “Molecular Pharmaceutics”

cp-asiAR may effectively treat androgenetic alopecia by promoting hair growth and reducing androgen receptor activity.

Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors

research Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors

May 2023 in “Journal of Endocrinology and Reproduction”

Blocking cholesterol production may help control hair loss in Primary Cicatricial Alopecia by affecting key regulators.

research Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model

69 citations , February 2008 in “The American journal of pathology”

Controlled delivery of specific RNA and IL-4 restored hair growth in mice with autoimmune alopecia.

research Histidine decarboxylase expression influences the neofolliculogenesis of newborn mouse dermal cells

2 citations , June 2012 in “Journal of Dermatological Science”

The gene HDC is important for the development of hair follicles in newborn mice.

research DKK1-targeting cholesterol-modified siRNA implication in hair growth regulation

1 citations , May 2023 in “Biochemical and Biophysical Research Communications”

Blocking DKK1 with siRNA can improve hair growth.

research Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders

20 citations , December 2020 in “Frontiers in Immunology”

The immune processes causing VKH and vitiligo are similar in dogs and humans.

research Delivery Strategies of siRNA Therapeutics for Hair Loss Therapy

1 citations , July 2024 in “International Journal of Molecular Sciences”

Effective delivery systems are crucial for siRNA hair loss treatments to work better.

research Transposon control as a checkpoint for tissue regeneration

14 citations , November 2022 in “Development”

Controlling transposable elements is crucial for successful tissue regeneration.

research Therapeutic small extracellular vesicles from key human stem and immune cellular sources: A review

January 2026 in “Journal of Biomedical Research”

Small extracellular vesicles from stem and immune cells show promise for treating various diseases but face challenges in clinical use.

research The influence of interferon on healthy and diseased skin

32 citations , December 2018 in “Cytokine”

Type I interferons play a key role in the development of various skin diseases.

research Hair Coloration by Gene Regulation: Fact or Fiction?

15 citations , November 2015 in “Trends in biotechnology”

Gene regulation could revolutionize hair color by altering pigmentation from within.

research Cutaneous Drug Delivery: An Update

25 citations , December 2013 in “Journal of Investigative Dermatology Symposium Proceedings”

New methods like nanoparticles and microneedles show promise for better skin drug delivery, especially for hair disorders.

research Targeting the Wnt pathways for therapies

112 citations , January 2014 in “Molecular and cellular therapies”

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

research Formation of the cornified envelope

3 citations , September 2005 in “Experimental dermatology”

The cornified envelope is crucial for skin's barrier function and involves key proteins and genetic factors.

Screening and Identification of LncRNAs Related to Villus Growth of Liaoning Cashmere Goats and Their Effects on Growth After FGF5 Treatment

research Screening and Identification of LncRNAs Related to Villus Growth of Liaoning Cashmere Goats and Their Effects on Growth after FGF5 Treatment

August 2019 in “Research Square (Research Square)”

Certain long non-coding RNAs in cashmere goats affect hair growth when treated with a specific growth factor.

research A symphony of signals: the intricate role of lncRNAs in dermatological disorders

1 citations , November 2025 in “Clinical and Experimental Medicine”

lncRNAs are important for understanding and treating skin diseases.

research Somatostatin Expression in Human Hair Follicles and Its Potential Role in Immune Privilege

27 citations , January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

Somatostatin may help protect hair follicles from immune attacks.

research The Immune Functions of Keratinocytes in Skin Wound Healing

147 citations , November 2020 in “International Journal of Molecular Sciences”

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

research Novel TMEM173 Mutation and the Role of Disease Modifying Alleles

47 citations , December 2019 in “Frontiers in immunology”

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

research Comprehensive analysis of circRNAs from cashmere goat skin by next generation RNA sequencing (RNA-seq)

39 citations , January 2020 in “Scientific Reports”

Four circRNAs were found to be significantly different in cashmere goat skin, affecting cashmere fineness.

research Future Directions in the Treatment of Vitiligo

3 citations , March 2018

New treatments for vitiligo may focus on protecting melanocyte stem cells from stress and targeting specific pathways involved in the condition.

Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid Lupus Erythematosus by Weighted Gene Co-Expression Network Analysis

research Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid LupusErythematosus by Weighted Gene Co-Expression Network Analysis

December 2022 in “Research Square (Research Square)”

Key genes linked to immune response are upregulated in hair follicles and skin tissues in chronic discoid lupus erythematosus.

research Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid Lupus Erythematosus by Weighted Gene Co-Expression Network Analysis

October 2022 in “Research Square (Research Square)”

Key genes linked to immune response are highly active in lupus-affected hair follicles.