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Steroid 5α-reductase evolved from protists and diversified in eukaryotes, with specific roles in mammals and plants.

The 2024 guideline updates recommendations for genetic testing, imaging, and sperm retrieval in male infertility.

Men who start puberty later may have lower sperm quality and different hormone levels in adulthood.

Finasteride improves hair but may reduce sperm quality at higher doses.

Advancements in reproductive technologies for carnivores help conserve species and offer insights into human reproductive issues.

A man's breast enlargement from low-dose finasteride for hair loss didn't go away, even with treatment, and might be more common than reported.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

KATP channel openers may cause peripheral edema by reducing lymphatic contractions and flow.

Myo-inositol and D-chiro-inositol, especially in a 40:1 ratio, effectively treat PCOS by improving insulin sensitivity and ovulation.

Origanum vulgare leaf extract reduces liver and kidney damage caused by finasteride in mice.

Higher androgen levels during puberty are linked to shorter adult height in boys with Silver-Russell syndrome.

Understanding genes and hormones is crucial for managing male puberty and sex development disorders.

Targeting protein S-palmitoylation could lead to new skin disease treatments.

The meeting highlighted promising genetic treatments for male fertility issues but noted concerns about certain cancer risks and ICSI safety.

Hairless protein can block vitamin D activation in skin cells.

Certain gene variants can influence acne risk and severity.

DA-9401 protects against hair loss, improves organ function, and prevents infertility caused by finasteride.

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

Testosterone affects brain functions and contributes to sex differences, influencing conditions like autism.

Finasteride doesn't harm male fertility or sperm quality, but may slightly reduce ejaculate volume.

Finasteride doesn't change rat testicle weight or sperm production.

Finasteride 1-mg doesn't harm sperm or pregnancy chances.

Men and women in infertile couples feel using donor sperm may cause more stress and marital issues than using donor eggs.

Father's finasteride use may affect son's fertility and testicular function.

PDRN, derived from salmon sperm, shows promise in healing wounds, reducing inflammation, and regenerating tissues, but more research is needed to understand its mechanisms and improve its use.

Resveratrol helps prevent finasteride-induced damage in male rats, improving reproductive function.

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

Stem cell niches support, regulate, and coordinate stem cell functions.

Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.

A man with testotoxicosis was fertile despite low FSH levels, suggesting high testosterone may allow sperm production without FSH.