research A Mouse Model for Conditional Expression of Activated β-Catenin in Epidermal Keratinocytes
Activated β-catenin affects hair growth and skin thickness, and changes are reversible.
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research NF-κB in biology and targeted therapy: new insights and translational implications
NF-κB signaling is crucial in many diseases and can be targeted for new treatments.
research Characterisation of CD4+ stem cells of the skin and their role in skin homeostasis and tumourigenesis
CD4+ skin cells may be precursors to basal cell carcinoma.
research Characterisation of Myotonic Dystrophy type I cell models and drug evaluation by a cell- based quantification platform.
The study on Myotonic Dystrophy type I (DM1) focuses on characterizing cell models and evaluating potential therapies using a cell-based quantification platform. It highlights the roles of DMPK and MBNL1 proteins in DM1 pathology, where misregulation and sequestration lead to disrupted splicing and multisystemic symptoms. The research identifies antisense oligonucleotides (ASOs) as promising therapeutic agents, capable of increasing MBNL1 protein levels without affecting DMPK protein levels. The study underscores the importance of robust in vitro models and advanced techniques like digital droplet PCR and In-Cell Western for drug screening and understanding DM1's complex molecular mechanisms.
research The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target
Targeting the HEDGEHOG-GLI1 pathway could help treat keloids.
research A Review on Nanoparticle Based Herbal Remedies for the Management of Alopecia
Nanoparticle-based herbal remedies could be promising for treating hair loss with fewer side effects and lower cost, but more research is needed.
research Posters Presented at the 19th Joint Meeting of the International Society of Dermatopathology, March 2–3, 2016, Hilton Crystal City at Washington Reagan National Airport, Arlington, Virginia, USA
The meeting showcased rare skin disease cases, highlighting the need for accurate diagnosis and treatment.
research An Investigation of Keratin 15 Function by Small Interfering Ribonucleic Acid Technology
Keratin 15 affects cell behavior and characteristics in skin cells.
research Calreticulin: non‐endoplasmic reticulum functions in physiology and disease
Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.
research Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning
Changing how mesenchymal stromal cells are grown can improve their healing abilities.
research KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype
Removing both KLK5 and KLK7 proteins can prevent death and skin issues in Netherton syndrome.
research Compartmentalized organization: a common and required feature of stem cell niches?
Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.
research Pattern Hair Loss in Men
Male pattern hair loss caused by follicular miniaturization; early diagnosis and treatment can reduce psychological burden.
research An Ovol2‐Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation
The Ovol2-Zeb1 circuit is crucial for skin healing and hair growth by guiding cell movement and growth.
research The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine
Hair follicles are valuable for regenerative medicine and wound healing.
research Topical application of synthetic melanin promotes tissue repair
Synthetic melanin applied to skin speeds up wound healing.
research Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells in vitro by Forming a Complex With Tcf4 and β-Catenin
Twist1 helps maintain important features of cells crucial for hair growth by working with Tcf4 and β-catenin.
research Efficacy of an agonist ofα-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation
Palmitoyl tetrapeptide-20 may help reduce hair greying and increase melanin production.
research THE EFFECT OF HAIR TONIC FROM SECRETOME MESENCHYMAL STEM CELL ON HAIR GROWTH IN HAIR LOSS CASES
A 10% MSC secretome hair tonic best promotes hair growth in alopecia.
research EXPLORING THE ROLE OF UMBILICAL CORD AND CORD BLOOD IN REGENERATIVE MEDICINE
Umbilical cord and cord blood stem cells are promising for treating chronic diseases due to their versatility and ethical acceptability.
research WPŁYW INFLUENCERÓW NA KOMUNIKACJĘ MEDYCZNĄ: DOBRE I ZŁE STRONY NOWEGO FENOMENU
Influencers impact medical communication both positively and negatively.
research INTEGRAL MANAGEMENT OF THE PATIENT WITH EPILEPSY
Effective epilepsy management involves accurate diagnosis, understanding seizure types, identifying causes, and choosing the right treatment.
research CZY SZTUCZNA INTELIGENCJA MA I BĘDZIE MIAŁA WPŁYW NA EFEKTYWNIEJSZE LECZENIE W CHIRURGII NACZYNIOWEJ?
AI improves vascular surgery by enhancing diagnostics, planning, and monitoring.
research ROBOTYKA W STOMATOLOGII: OBECNE ZASTOSOWANIA I PRZYSZŁE KIERUNKI
Robotics will greatly change dentistry with ongoing tech advancements.
research POSTĘP W DIAGNOZIE I LECZENIU STWARDNIENIA ROZSIANEGO
AI and advanced technologies are improving medical diagnostics and treatments.
research KRAKOWSCY UCZNIOWIE ESKULAPA
In the late 19th century, Jagiellonian University in Krakow was a hub for medical innovations in surgery, diagnostics, and cardiology.
research DEPRESJA W XXI WIEKU – STARA CHOROBA, NOWE ROZWIĄZANIA
New methods are improving treatment for depression.
research MEDYCYNA LOTNICZA I KOSMICZNA, ROLA LEKARZA I WYZWANIA DŁUGOTERMINOWYCH LOTÓW W KOSMOS
Doctors ensure the health and safety of pilots and astronauts in challenging aviation and space environments.
research SYNERGIA AI I MEDYCYNY: SZANSE I WYZWANIA
AI is transforming healthcare by improving diagnostics and therapy, despite challenges with data and trust.
research POSTAWY SPOŁECZNE MŁODZIEŻY W KRAJACH PO OBU STRONACH WSCHODNIEJ GRANICY UE WOBEC OSÓB Z OGRANICZONĄ MOBILNOŚCIĄ W OBLICZU KONSEKWENCJI WOJNY W UKRAINIE
Ukrainian students affected by war showed more positive attitudes towards people using wheelchairs.