56 citations
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February 2006 in “American journal of physiology. Cell physiology” Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.
46 citations
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December 1992 in “The Journal of Steroid Biochemistry and Molecular Biology” Affected males are born with ambiguous genitalia, raised as females, but develop male traits at puberty due to enzyme deficiency.
43 citations
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January 2006 in “PubMed” Androgens and estrogens are crucial for male reproductive health, affecting hormone levels and tissue function.
34 citations
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December 1991 in “Annals of the New York Academy of Sciences” Differences in enzyme activity and androgen receptors in hair follicles may explain why hair loss appears differently in men and women.
30 citations
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August 1984 in “Archives of Dermatology” Antiandrogen therapy, like cyproterone acetate, effectively treats acne, hirsutism, and hair loss.
22 citations
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October 2001 in “Biochemical Pharmacology” GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.
8 citations
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March 2020 in “Metabolites” Finasteride treatment changes urine metabolomics and steroid signatures, potentially monitoring effectiveness but may cause sexual side effects.
7 citations
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October 2019 in “Case reports in endocrinology” A young woman's symptoms suggested PCOS, but tests and surgery confirmed and treated a rare ovarian tumor, resolving her condition.
5 citations
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January 1983 in “PubMed” Human skin releases different steroids, with some coming from sebaceous glands and others from sweat glands.
4 citations
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November 2022 in “Frontiers in endocrinology” The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.
2 citations
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August 2025 in “Harm Reduction Journal” Non-medical steroid use in gym-goers is risky and needs better prevention and care strategies.
1 citations
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January 2015 in “Elsevier eBooks” Certain pesticides and fungicides can interfere with male hormone functions, potentially causing reproductive issues in male rats.
1 citations
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January 2003 in “Expert Opinion on Therapeutic Patents” Steroid sulfatase inhibitors could potentially treat hormone-related disorders like certain cancers, hair loss, acne, and improve cognitive dysfunction.
1 citations
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February 1954 in “Journal of the American Geriatrics Society” Steroid hormones can help treat aging issues and improve health in elderly people.
January 2026 in “Biomedicines” Dysregulated lipid metabolism may play a role in male pattern baldness.
November 2025 in “Open Access CRIS of the University of Bern” Androgen levels are more linked to body size in boys than girls.
November 2025 in “European Journal of Endocrinology” Hair steroid profiling is a feasible, non-invasive alternative to serum analysis for assessing hormone levels and metabolism.
August 2025 in “Al-Salam Journal for Medical Science” Steroid hormones are vital for body functions and disease management.
May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.
January 2022 in “Journal of Morphological Sciences” A woman's rare ovarian tumor was treated with surgery, which stopped her symptoms and normalized her hormone levels.
December 1976 in “PubMed” Androgens affect skin conditions like acne and hirsutism, treatable with hormone therapy and other methods.
April 2014 in “The FASEB Journal” Women with androgenetic alopecia often have other symptoms of high androgen levels, requiring further hormone testing.
December 2006 in “8th European Congress of Endocrinology incorporating the British Endocrine Societies” Men with early hair loss and hormonal changes like PCOS could be the male equivalent of PCOS, not linked to metabolic syndrome.
December 1990 in “PubMed” Hirsutism and androgenetic alopecia in women are often due to increased androgen effects, and antiandrogen treatment is recommended to prevent further issues.
227 citations
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January 1998 in “Journal of biological chemistry/The Journal of biological chemistry” Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.
59 citations
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January 1976 in “Vitamins and hormones” Prostate cells have proteins that bind to specific hormones, which can increase protein production when activated by these hormones.
56 citations
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December 2002 in “The Journal of Clinical Endocrinology & Metabolism” Human bone cells mainly produce a type 1 enzyme that may help regulate bone health.
52 citations
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December 2000 in “Archives of Dermatological Research” Scalp skin barrier affects hair loss; personalized treatments needed.
19 citations
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December 2011 in “PubMed” Inflammation and immunity play a key role in androgenetic alopecia, with better treatment outcomes in certain immune-positive cases.
17 citations
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January 2013 in “Case Reports in Medicine” Steroid cell tumors in the ovary are rare, can cause hormone-related symptoms, and require surgery.