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Modifying steroidal inhibitors shows promise for developing new cancer treatments.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

The study created a new method to test drugs that affect hormone processing in skin.

Women with PCOS have higher 5alpha-reductase activity, affecting steroid levels.

Steroid hormone binding in rat skin varies with pH, heat, and hair cycle phases.

Bone mineral and minocycline boost bone cell growth, aiding healing.

Steroid hormones may affect sexual maturation in cod by altering certain KCa channel expressions.

Combining 5α-reductase and aromatase inhibitors may better reduce estrogen levels.

DHEA affects various tissues by interacting with multiple receptors and can be converted into sex hormones.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

Researchers created human cells that can turn into sebocytes, which may help study and treat skin conditions like acne.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

A new compound with strong antiandrogenic effects was found, potentially useful for treating conditions like acne and prostate cancer.

Glioblastoma cells can make androgens, which might help the tumor grow.

Neurosteroids may help treat disorders with too much dopamine activity.

Researchers created a new method to measure brain steroids, finding higher levels of certain steroids and changes due to a drug.

Androgens and estrogens are crucial for male reproductive health, affecting hormone levels and tissue function.

Certain derivatives are more effective 5α-reductase type 2 inhibitors than finasteride.

Postmenopausal ovary stromal cells have a unique makeup and limited steroid production, suggesting androgens come from the adrenal gland.

Researchers found a gene in hamsters that responds to male hormones and may be indirectly controlled by them.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Dexamethasone may influence hair growth by altering estrogen receptor activity in hair cells.

Steroid hormones can be preserved in ancient hair, revealing insights into past health and fertility.

Increased 11β-HSD1 activity in skin may contribute to aging and could be targeted to reduce aging effects.

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

The pituitary gland functions normally even after losing most SOX2+ stem cells.

Activating androgen receptors in muscle can increase muscle mass and reduce fat.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Dihydrotestosterone (DHT) increases oil production in skin cells by activating mTOR, and mTOR inhibitors can reduce this effect.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.