93 citations
,
January 2007 in “Skin Pharmacology and Physiology” Caffeine in shampoo quickly enters the body through hair follicles.
90 citations
,
November 2014 in “Journal of Biomedical Optics” Silver nanoparticles can penetrate porcine skin up to about 15.6 μm, possibly through hair follicles.
87 citations
,
September 2016 in “Journal of Controlled Release” Nanoparticles can improve drug delivery to hair follicles but struggle to penetrate deeper skin layers.
67 citations
,
January 2012 in “Biological and Pharmaceutical Bulletin” Nanoparticles don't penetrate intact skin but can enter through pores or damaged skin.
66 citations
,
February 2002 in “Veterinary dermatology” Malassezia in cat skin biopsies may indicate internal cancer.
64 citations
,
October 2017 in “Colloids and surfaces. B, Biointerfaces” Chitosan-coated nanoparticles can effectively deliver positively charged drugs through the skin using iontophoresis.
62 citations
,
October 2010 in “Journal of biomedical nanotechnology” Nanoparticles can enter the skin, potentially causing toxicity, especially in damaged skin.
62 citations
,
May 1997 in “Journal of Pharmaceutical Sciences” Sebaceous glands in the skin play a key role in absorbing the antiandrogen drug RU 58841, especially when it's encapsulated in liposomes.
61 citations
,
May 2016 in “Scientific reports” The peptide IMT-P8 can effectively deliver proteins into the skin and cells for potential skin treatments.
60 citations
,
January 2023 in “Biomaterials Science” PLGA-based microneedles are promising for safe and effective skin delivery of drugs and vaccines.
60 citations
,
August 1969 in “British Journal of Dermatology” Germicides mostly stay on the skin's surface, but some penetrate deeper depending on the product used.
55 citations
,
June 2013 in “Dermatologic Surgery” Ablative fractional resurfacing could improve how well topical drugs penetrate the skin, but more research is needed to fine-tune the method.
49 citations
,
May 1974 in “Biochimica et Biophysica Acta (BBA) - Protein Structure” Transamidases are present in the epidermis but their exact role is unclear.
48 citations
,
July 2023 in “Biomedicines” Hydrogel-forming microneedles are promising for safe, efficient, and controlled drug delivery through the skin.
48 citations
,
March 1997 in “Veterinary Dermatology” Some cats with sudden hair loss and tiredness might have cancer-related alopecia.
46 citations
,
April 2020 in “Clinical Cosmetic and Investigational Dermatology” Hydroquinone may harm skin, while kojic acid and aloe vera could reduce its negative effects.
44 citations
,
May 2008 in “Acta Zoologica” Keratinization in embryos helped vertebrates adapt to land by forming a protective skin barrier.
41 citations
,
May 2018 in “Nutrition and healthy aging” Skin aging is largely due to differences in stiffness and elasticity between skin layers, leading to wrinkles.
40 citations
,
January 2022 in “Frontiers in Chemistry” The patch speeds up deep wound healing.
34 citations
,
August 2019 in “Journal of Allergy and Clinical Immunology” mTORC2 is crucial for healthy skin barrier by regulating lipids and filaggrin.
34 citations
,
October 2014 in “European journal of pharmaceutics and biopharmaceutics” The new drug delivery system releases the drug better in sebum and targets follicles more effectively than the conventional cream.
34 citations
,
October 1994 in “Journal of Pharmaceutical Sciences” Ethanol over 50% helps minoxidil absorb better into skin.
34 citations
,
June 1992 in “Journal of Cutaneous Pathology” Harlequin ichthyosis involves abnormal skin cell structures and giant mitochondria, affecting skin and hair.
33 citations
,
June 2007 in “International Journal of Pharmaceutics” The conclusion is that measuring how drugs partition into artificial sebum is important for predicting their delivery into hair and sebaceous follicles, and it provides better information than traditional methods.
31 citations
,
July 2012 in “Journal of Lipid Research” ACBP is crucial for healthy skin in mice.
28 citations
,
September 2013 in “European Journal of Histochemistry” Keratins in Malayan pangolins vary by region, suggesting scales evolved from the tail towards the head.
27 citations
,
January 2016 in “Indian Dermatology Online Journal” Dermoscopy is better than a magnifying lens for examining skin because it shows deeper details.
26 citations
,
April 2024 in “Particle and Fibre Toxicology” Nanoplastics can penetrate skin cells, triggering inflammation and immune responses.
26 citations
,
December 2022 in “Future Journal of Pharmaceutical Sciences” Invasomes with natural terpenes can improve drug delivery through the skin.
26 citations
,
June 2020 in “Polymers” Microneedle made of iron oxide and PVA helps hair regrowth in alopecia treatment.