research Histochemical studies on cutaneous stem cells in human fetal skin
Basal layer skin cells help form the epidermis and hair follicles.
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510-540 / 1000+ resultsresearch 3 Vascular endothelial cells: targets for studying the activity of hair follicle cell-produced VEGF
research Innovative Liposomes as a Transfollicular Drug Delivery System: Penetration into Porcine Hair Follicles
Liposomes with certain properties can effectively deliver drugs deep into hair follicles.
research Immunolocalization of Scaffoldin, a Trichohyalin‐Like Protein, in the Epidermis of the Chicken Embryo
Scaffoldin helps form hard skin structures in chicken embryos.
research Differentiation of Adipose Derived Stem Cells by Stimulating with Extracellular Vesicles Secreted from Dermal Papilla Cells Activated with Osteogenic and Adipogenic Inducers
The study investigated the differentiation of adipose-derived stem cells (ASCs) into dermal papilla cell (DPC)-like cells using extracellular vesicles (EVs) from DPCs activated with osteogenic and adipogenic inducers. The research demonstrated that the CAO1/2 medium, when supplemented with FGF2 and PDGF-AA, enhanced the expression of hair-inductive genes and maintained DPC-specific properties, leading to increased hair-forming activity. The study highlighted the role of specific microRNAs in regulating hair growth and suggested that DPC-EVs could effectively transform ASCs into cells with hair formation activity. This approach showed potential for hair regeneration therapies, offering a novel method for treating hair-related conditions like alopecia. However, the study acknowledged limitations in understanding miRNA expression and the characterization of DPC-EVs, indicating a need for further research.
research A biopsy-sized 3D skin model with a perifollicular vascular plexus enables studying immune cell trafficking in the skin
A small 3D skin model helps study how immune cells move in the skin.
research Follicular unit extraction as a treatment modality for stable segmental inguinoscrotal vitiligo: A case report
Follicular unit extraction can effectively treat a specific type of vitiligo.
research Epidermoid Cyst in the Bitch Mammary Gland
An epidermoid cyst in a dog's mammary gland is rare and benign.
research Epidermolysis bullosa in calves in the United Kingdom
Epidermolysis bullosa in UK calves is not caused by mutations in keratin genes.
research Epidermolysis Bullosa
Epidermolysis bullosa is an inherited condition causing fragile skin with no cure, managed by wound care and experimental treatments show promise.
research Epidermal stem cells: Interplay with the skin microenvironment during wound healing
Epidermal stem cells work with the skin's environment to heal wounds effectively.
research Changes in fibronectin, laminin and type IV collagen distribution relate to basement membrane restructuring during the rat vibrissa follicle hair growth cycle.
The rat vibrissa follicle can quickly remodel its basement membrane during hair growth, affecting cell signaling and activity.
research Isolation of Stem Cells and Progenitors from Mouse Epidermis
A method was developed to isolate and study hair follicle stem cells from mouse skin.
research Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice
EGFR hyperactivation increases sebaceous gland size and sebum production in mice.
research Follicular mucinous nevus: A possible new variant of mucinous nevus
Researchers found a potential new type of skin growth called follicular mucinous nevus.
research Expression of dermcidin in sebocytes supports a role for sebum in the constitutive innate defense of human skin
Sebum helps protect human skin from microbes.
research Differentiation of the sebaceous gland
The exact molecular mechanisms of sebaceous gland function are still unclear.
research Role of boundary conditions in an experimental model of epithelial wound healing
Mast cells and VEGF contribute to post-surgery adhesions, and blocking VEGF can reduce these adhesions; also, certain factors affect wound healing and fetal skin heals differently with age.
research In this Issue
New findings on hair keratin, wound healing, and skin blistering were presented.
research Present and Future Use of Exosomes in Dermatology
Exosomes could be key in treating skin conditions and healing wounds.
research Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10–p63 axis in epithelial homeostasis
ZIP10 is crucial for skin development and maintaining healthy skin.
research Epithelial elements in superficial angiomyxomas: mimicry of adnexal development, and mesenchymal‐to‐epithelial transition
Epithelial elements in superficial angiomyxomas are non-neoplastic growths mimicking embryogenesis.
research Mechanistic insights of desmopressin loaded elastic liposomes for transdermal delivery: HSPiP predictive parameters and instrumental based evidences
Desmopressin-loaded liposomes can effectively deliver drugs through the skin, improving bioavailability and patient compliance.
research Identification of somatic and germline mosaicism for a keratin 5 mutation in epidermolysis bullosa simplex in a family of which the proband was previously regarded as a sporadic case
The keratin 5 mutation in a family with epidermolysis bullosa simplex was due to mosaicism, not a new mutation.
research Application of Cell-Derived Extracellular Vesicles and Engineered Nanovesicles for Hair Growth: From Mechanisms to Therapeutics
Tiny natural vesicles from cells might help treat hair loss.
research Skin Barrier Dysfunction in Acne Vulgaris: Pathogenesis and Therapeutic Approaches
Improving skin barrier function is crucial for better acne treatment.
research Keratins as an Inflammation Trigger Point in Epidermolysis Bullosa Simplex
Mutant keratins cause inflammation in Epidermolysis Bullosa Simplex, suggesting targeting them could help treat the disorder.
research Harnessing the intradermal delivery of hair follicle dermal papilla cell spheroids for hair follicle regeneration in nude mice
Delivering specific cell clusters into the skin can help regrow hair in mice.
research Dermal papilla cell-derived exosomes promote hair follicle regeneration during wound healing by activating Wnt/β‐catenin signaling pathway
Tiny particles from skin cells can help grow new hair by activating a specific growth signal during skin healing.
research Genetic basis of skin appendage development
Hair, teeth, and mammary glands develop similarly at first but use different genes later.