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GlossarySurvivin

protein that inhibits cell death and regulates cell division

Survivin is a protein that inhibits cell death (apoptosis) and is involved in regulating cell division. It is often found at high levels in cancer cells, making it a target for cancer therapies. In the context of hair and alopecia, its role in cell survival and proliferation could be significant for understanding hair follicle health and regeneration.

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research Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study

58 citations , May 2004 in “British Journal of Dermatology”

Diphenylcyclopropenone treatment helps hair growth in alopecia areata by promoting blood vessel growth and cell survival.

research Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I

29 citations , January 2016 in “Disease Markers”

Survivin and IGF-I may play a role in acne and scarring.

Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs

research Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs

11 citations , October 2019 in “Cancers”

Spironolactone may make some cancer treatments more effective by blocking a protein that helps cancer cells survive.

research A Therapeutic Role for Survivin in Mitigating the Harmful Effects of Ionizing Radiation

2 citations , January 2016 in “Sarcoma”

Inducing survivin in normal tissues can protect against radiation damage.

research Assessment of scalp hair survivin in patients with premature greying of hair

July 2025 in “International Journal of Dermatology Venereology and Leprosy Sciences”

Examining Survivin levels may help understand premature greying of hair.

research Serum Level of Survivin in Patients with Alopecia Areata and its Association with Disease Severity and Progression

February 2023 in “Suez Canal University Medical Journal”

Lower survivin levels in blood are linked to more severe and progressing alopecia areata.

research Severe Unilateral Alopecia in a Long-Term Surviving Male Adolescent Glioblastoma Multiforme Patient

June 2025 in “Clinical Cosmetic and Investigational Dermatology”

There's an urgent need for better treatments for hair loss caused by radiation therapy.

research Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling

43 citations , January 2016 in “Cellular physiology and biochemistry”

Epidermal Growth Factor helps hair follicle cells grow and move by activating a specific cell signaling pathway.

research Targeted disruption of Bcl‐x_L in mouse keratinocytes inhibits both UVB‐ and chemically induced skin carcinogenesis

36 citations , March 2009 in “Molecular Carcinogenesis”

Disrupting Bcl-xL in mice reduces skin cancer risk.

research Platelets Facilitate Wound Healing by Mitochondrial Transfer and Reducing Oxidative Stress in Endothelial Cells

27 citations , February 2023 in “Oxidative Medicine and Cellular Longevity”

Platelets help heal wounds by transferring mitochondria to cells, reducing stress and cell death.

Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells In Vitro by Forming a Complex With Tcf4 and β-Catenin

research Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells in vitro by Forming a Complex With Tcf4 and β-Catenin

13 citations , August 2020 in “Frontiers in Cell and Developmental Biology”

Twist1 helps maintain important features of cells crucial for hair growth by working with Tcf4 and β-catenin.

research From stem cells protection to skin microbiota balance: Orobanche rapum extract, a new natural strategy

9 citations , November 2018 in “Journal of cosmetic dermatology”

Orobanche rapum extract rejuvenates skin and protects skin bacteria, leading to healthier skin.

research Proteomics as a tool to improve novel insights into skin diseases: what we know and where we should be going

3 citations , October 2022 in “Frontiers in Surgery”

Proteomics combined with other technologies can lead to a better understanding of skin diseases.

research Цинк-зависимые факторы в регуляции цикла фолликула волоса

January 2014 in “Международный журнал прикладных и фундаментальных исследований”

Zinc affects hair growth and may be linked to hair loss.

research Genome scan for signatures of adaptive evolution in wild African goat (capra nubiana)

August 2021

Wild African goats have genetic adaptations for surviving harsh desert conditions.

research PRZEWLEKŁY STAN KRYTYCZNY: WSPÓŁCZESNE SPOJRZENIE NA PROBLEM

January 2024 in “Wiadomości Lekarskie”

Chronic critical illness often leads to long ICU stays and ongoing health issues after surviving the initial critical phase.

research Donor hair follicle preservation by partial follicular unit extraction. A method to optimize hair transplantation

19 citations , April 2010 in “Journal of Dermatological Treatment”

Partial hair follicle extraction can effectively double the number of hair follicles for transplants, with most surviving and growing normally after a year.

research Cerebellar Medulloblastoma: Treatment by Irradiation of the Whole Central Nervous System

1 citations , April 1953 in “Acta Radiologica”

Irradiating the whole central nervous system can lead to over 50% of patients with cerebellar medulloblastoma surviving three years.

research Hot Comb Alopecia

107 citations , September 1968 in “Archives of Dermatology”

Using hot combs can cause permanent hair loss on the scalp's crown.

research CRISPR/Cas9‐mediated loss of FGF5 function increases wool staple length in sheep

47 citations , June 2017 in “The FEBS journal”

Disabling the FGF5 gene in sheep leads to longer wool.

research SYK inhibitor entospletinib prevents ocular and skin GVHD in mice

45 citations , October 2018 in “JCI Insight”

Entospletinib effectively prevents eye and skin GVHD in mice.

research Tanshinone IIA pretreatment protects free flaps against hypoxic injury by upregulating stem cell-related biomarkers in epithelial skin cells

13 citations , September 2014 in “BMC Complementary and Alternative Medicine”

Tanshinone IIA helps protect skin tissue from low oxygen damage by boosting certain cell markers.

MTORC1 Activity Negatively Regulates Human Hair Follicle Growth and Pigmentation

research Hot comb alopecia.

112 citations , September 1968 in “PubMed”

Hot comb use can cause permanent hair loss on the scalp.

research Towards Defining the Pathogenesis of the Hairless Phenotype

86 citations , June 1998 in “Journal of Investigative Dermatology”

The hairless gene mutation causes baldness by disrupting hair follicle structure.

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Related Terms

Research

research Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study

research Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I

research Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs

research A Therapeutic Role for Survivin in Mitigating the Harmful Effects of Ionizing Radiation

research Assessment of scalp hair survivin in patients with premature greying of hair

research Serum Level of Survivin in Patients with Alopecia Areata and its Association with Disease Severity and Progression

research Severe Unilateral Alopecia in a Long-Term Surviving Male Adolescent Glioblastoma Multiforme Patient

research Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling

research Targeted disruption of Bcl‐x_L in mouse keratinocytes inhibits both UVB‐ and chemically induced skin carcinogenesis

research Platelets Facilitate Wound Healing by Mitochondrial Transfer and Reducing Oxidative Stress in Endothelial Cells

research Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells in vitro by Forming a Complex With Tcf4 and β-Catenin

research From stem cells protection to skin microbiota balance: Orobanche rapum extract, a new natural strategy

research Proteomics as a tool to improve novel insights into skin diseases: what we know and where we should be going

research Цинк-зависимые факторы в регуляции цикла фолликула волоса

research Genome scan for signatures of adaptive evolution in wild African goat (capra nubiana)

research PRZEWLEKŁY STAN KRYTYCZNY: WSPÓŁCZESNE SPOJRZENIE NA PROBLEM

research Donor hair follicle preservation by partial follicular unit extraction. A method to optimize hair transplantation

research Cerebellar Medulloblastoma: Treatment by Irradiation of the Whole Central Nervous System

research Hot Comb Alopecia

research CRISPR/Cas9‐mediated loss of FGF5 function increases wool staple length in sheep

research SYK inhibitor entospletinib prevents ocular and skin GVHD in mice

research Tanshinone IIA pretreatment protects free flaps against hypoxic injury by upregulating stem cell-related biomarkers in epithelial skin cells

research mTORC1 activity negatively regulates human hair follicle growth and pigmentation

research Diffuse Hair Loss Following Multiple Honeybee Stings

research Using the follicular unit extraction technique in treatment of male androgenetic alopecia

research Treatment of invasive aspergillosis with itraconazole

research Tissue engineering of human hair follicles using a biomimetic developmental approach

research Cerebellar Medulloblastoma: Treatment by Irradiation of the Whole Central Nervous System

research Hot comb alopecia.

research Towards Defining the Pathogenesis of the Hairless Phenotype