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research Synthesis and biological activity evaluation of new isatin-gallate hybrids as antioxidant and anticancer agents (in vitro) and in silico study as anticancer agents and coronavirus inhibitors

3 citations , June 2024 in “Pharmacia”

New isatin-gallate hybrids show promise as antioxidants, cancer treatments, and coronavirus inhibitors.

research Synthesis and biological evaluation of dimeric peptide derivatives as proliferation‐stimulating agents in human follicle dermal papilla cells

3 citations , September 2021 in “Bulletin of the Korean Chemical Society”

Dimeric peptide derivatives could help hair growth and treat hair loss safely.

$Synthesis and Structural Characterization of a New Dinuclear Platinum(III) Complex, [Pt2Cl4(NH3)2{μ-HN=C(O)Bu^t}2]$

research Synthesis and structural characterization of a new dinuclear platinum(III) complex, [Pt₂Cl₄(NH₃)₂{μ-HN=C(O)Bu^t}₂]

2 citations , November 2022 in “Acta crystallographica. Section B, Structural science, crystal engineering and materials./Acta crystallographica. Section B, Structural science, crystal engineering and materials”

A new platinum complex was made and studied, which might help fight cancer better.

research Synthesis and Evaluation of Finasteride-Loaded HPMC-Based Nanogels for Transdermal Delivery: A Versatile Nanoscopic Platform

2 citations , January 2022 in “BioMed Research International”

Finasteride-loaded nanogels are effective, safe, and improve drug absorption through the skin.

Synthesis of Novel Iron Nanoparticles Using the Aqueous Extract of the Pumpkin Plant and Their Use in the Treatment of Burns

research Synthesis of novel Iron Nanoparticles using the aqueous extract of the Pumpkin plant, and used it in the treatment of burns

2 citations , October 2021 in “Egyptian Journal of Chemistry”

Iron nanoparticles made from pumpkin extract effectively treated burns and promoted healing in mice.

research Synthesis and biological activity of raltitrexed-carrier conjugates.

2 citations , March 2010 in “Acta Biochimica Polonica”

Raltitrexed conjugates are less potent than the free drug but more effective at high concentrations.

research Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System

1 citations , December 2021 in “Androgens”

Testosterone and its metabolites affect brain functions and could help treat neurological disorders.

research Synthesis and Study of Some 17a-aza-D-homo Steroids as 5α-Reductase Inhibitors

1 citations , October 2020 in “Current Drug Discovery Technologies”

The research found that compound 6, a newly created steroid, is more effective at inhibiting 5α-reductase (an enzyme) than current treatments, suggesting it could be a better option for treating urinary tract symptoms in men.

research FACILE WATER MEDIATED SYNTHESIS OF FINASTERIDE FORM-I, AN AZAANDROSTANE STEROID

1 citations , January 2007 in “Heterocyclic Communications”

A simple and eco-friendly method was developed to make finasteride Form-I using water.

research Synthesis of Sericin based Stretchable and Self-healing Hydrogel Loaded with Psidium guajava L. Extract for Treatment of Burn Wound

January 2026 in “Journal of Burn Care & Research”

The hydrogel with sericin and guava extract significantly improved burn wound healing in mice.

research Synthesis of a new amino acid derivative with long‐lasting hair shape control effects and elucidation of its mechanisms

February 2025 in “International Journal of Cosmetic Science”

A new amino acid derivative, ATS, improves hair texture and moisture, making it easier to straighten curly hair.

Synthesis of Cu4O3 Nanoparticles Using Pumpkin Seed Extract: Optimization, Antimicrobial, and Cytotoxicity Studies

research Synthesis of Cu ₄ O ₃ nanoparticles using pumpkin seed extract: Optimization, antimicrobial, and cytotoxicity studies

January 2025 in “Nanotechnology Reviews”

Pumpkin seed extract can create copper oxide nanoparticles with potential antibacterial and cancer-fighting properties.

Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides and Their Effect on 5α-Reductase Isoform 2, Androgen Receptor, and Androgen-Dependent Glands

research Synthesis of novel andostane-N-cyclohexyl-17-carboxamides, and their effect on the 5α-reductase isoform 2, the androgen receptor, and androgen-dependent glands

November 2021 in “Pharmaceutical Sciences”

New compounds were made and tested, with compound 6 showing potential for treating prostate-related diseases.

research Synthesis, Biological Evaluation and in silico Studies of Novel 5α-aza-Bhomo-3,5-secosteroids as Potential 5-reductase Inhibitors

October 2016 in “Letters in Drug Design & Discovery”

research Synthesis of avicequinone c and analogs toward the study of 5α-reductase inhibitory activity

January 2015

2-Hydroxy-1,4-naphthoquinone is a strong 5α-reductase inhibitor.

research Synthesis and anticancer activity evaluation of Novel 6 mercaptopurine derivatives.

January 2015 in “Journals & Books Hosting (International Knowledge Sharing Platform)”

Compound 1 showed promising anticancer activity.

research Synthesis of 4-amidinoimidazoles incorporating a cyanamide moiety : novel precursors for biologically important purines

November 2012 in “Journal of Clinical Pathology”

research Synthesis of 5α-Reductase Special inhibitor Finasteride

January 2009 in “Journal of Xingtai University”

Finasteride is made through a series of chemical reactions starting from a specific intermediate compound.

research Synthesis of finasteride

January 2007 in “The Journal of Pharmaceutical Practice”

The process to make finasteride is simple, cheap, and gives a good amount.

research Synthesis of Finasteride,5α-reductase inhibitors

January 2003 in “Natural Science Journal of Xiangtan University”

The improved process makes Finasteride suitable for industrial production.

research Synthesis of mimics of steroid A ring as potential enzyme inhibitors

September 2002 in “Research Repository (Kingston University London)”

Mimicking the steroid A-ring may help create effective enzyme inhibitors for prostate disease treatment.

research Synthesis, Characterization and Evaluation of 5α, 6β-Dihalo Androsterone Derivatives as 5α-Reductase Inhibitors

May 2022 in “Current Enzyme Inhibition”

Compound 7b is a promising candidate for treating benign prostatic hyperplasia and prostate cancer.

Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations , August 2011 in “Cancer research”

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

research Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep

100 citations , April 2007 in “Neuroscience”

Reducing neurosteroid levels worsens brain injury in fetal sheep.

Novel Synthesis of Nicotinamide Derivatives with Cytotoxic Properties

research Novel synthesis of nicotinamide derivatives of cytotoxic properties

51 citations , March 2006 in “Bioorganic & Medicinal Chemistry”

Newly made nicotinamide compounds could potentially treat cancer.

research Leveraging nature’s nanocarriers: Translating insights from extracellular vesicles to biomimetic synthetic vesicles for biomedical applications

49 citations , February 2025 in “Science Advances”

Biomimetic synthetic vesicles could improve precision medicine by combining natural and synthetic benefits.

research <p>Effect of Hyaluronic Acid and Poly-L-Lactic Acid Dermal Fillers on Collagen Synthesis: An in vitro and in vivo Study</p>

34 citations , September 2020 in “Clinical, cosmetic and investigational dermatology”

Hyaluronic acid increases collagen synthesis safely, while poly-L-lactic acid may cause complications by affecting fibroblasts.

research Neo-synthesis of estrogenic or androgenic neurosteroids determine whether long-term potentiation or depression is induced in hippocampus of male rat

32 citations , October 2015 in “Frontiers in Cellular Neuroscience”

DHT is needed for long-term depression, while E2 is needed for full long-term potentiation in male rat brains.

research peri ‐Xanthenoxanthene (PXX): a Versatile Organic Photocatalyst in Organic Synthesis

11 citations , April 2021 in “Advanced synthesis & catalysis”

PXX is an effective and affordable photocatalyst for creating new chemical bonds in organic synthesis.

research Anti-Zika Activity of a Library of Synthetic Carbohydrate Receptors

11 citations , March 2019 in “Journal of Medicinal Chemistry”

Some synthetic carbohydrate receptors, especially compounds 3 and 15, show strong potential for treating Zika virus.

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