Search

for
Search:

Did you mean Regulatory T Cells?

GlossaryRegulatory T Cells

specialized immune cells that prevent autoimmune responses

Regulatory T Cells, often abbreviated as Tregs, are a specialized subset of T cells in the immune system that help maintain immune tolerance and prevent autoimmune diseases. They function by suppressing the activity of other immune cells, thereby preventing excessive or misdirected immune responses that could damage the body's own tissues.

Related Terms

Sort by

Research

30 / 1000+ results

Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease

research Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease

30 citations , July 2019 in “PloS one”

Patients with Alopecia areata have fewer specific immune cells that normally regulate the immune system, which may contribute to the condition.

research Low-Dose IL-2 for Treating Moderate to Severe Alopecia Areata: A 52-Week Multicenter Prospective Placebo-Controlled Study Assessing its Impact on T Regulatory Cell and NK Cell Populations

22 citations , September 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

The study's results on the effectiveness of low-dose IL-2 for alopecia areata and its impact on immune cells were not provided.

research A humanized IL-2 fusion protein enhances T regulatory cells in vivo and restrains disease in a murine model of Alopecia Areata 4760

November 2025 in “The Journal of Immunology”

A humanized IL-2 fusion protein boosts T regulatory cells and helps control hair loss in Alopecia Areata.

research The imbalance between Type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris

49 citations , August 2022 in “Frontiers in Immunology”

Psoriasis involves an imbalance between certain immune cells, and targeting these could help restore skin health.

research HuR ablation destabilizes Foxp3 mRNA and impairs regulatory T cell function, contributing to an autoimmune phenotype

1 citations , September 2025 in “Frontiers in Immunology”

HuR is essential for Treg function and preventing autoimmunity.

Human Regulatory T Cells: Role in Autoimmune Skin Diseases and Post-Transplant Nonmelanoma Skin Cancers

research Human Regulatory T Cells: Understanding the Role of Tregs in Select Autoimmune Skin Diseases and Post-Transplant Nonmelanoma Skin Cancers

1 citations , January 2023 in “International Journal of Molecular Sciences”

Understanding how Regulatory T Cells work could help create treatments for certain skin diseases and cancers.

research 039 Expansion of regulatory T Cells restrains pathogenic CD8 T Cells in a murine model of alopecia areata

July 2024 in “Journal of Investigative Dermatology”

Expanding regulatory T cells may help treat alopecia areata by reducing harmful immune cells.

research The potential of regulatory T cell-based therapies for alopecia areata

May 2023 in “Frontiers in Immunology”

Treg cell-based therapies might help treat hair loss from alopecia areata, but more research is needed to confirm safety and effectiveness.

research Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues

140 citations , March 2013 in “The journal of immunology/The Journal of immunology”

Memory regulatory T cells need IL-7, not IL-2, to stay in peripheral tissues.

T Helper 17 Cell/Regulatory T-Cell Imbalance in Hidradenitis Suppurativa/Acne Inversa: The Link to Hair Follicle Dissection, Obesity, Smoking, and Autoimmune Comorbidities

research T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities

66 citations , March 2018 in “British journal of dermatology/British journal of dermatology, Supplement”

An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.

research Regulatory T Cells in Autoimmune Diseases and their Potential

3 citations , November 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Enhancing regulatory T cells may help treat autoimmune diseases like alopecia areata.

research Imbalance of T‐helper 17 and regulatory T cells in patients with alopecia areata

62 citations , June 2015 in “The Journal of Dermatology”

People with alopecia areata have more Th17 cells and fewer Treg cells, which may be key to the condition's development.

CD80CD86 Deficiency Disrupts Regulatory CD4+FoxP3+ T Cell Homeostasis and Induces Autoimmune-Like Alopecia

research CD80CD86 deficiency disrupts regulatory CD4+FoxP3+T cell homoeostasis and induces autoimmune-like alopecia

6 citations , April 2017 in “Experimental dermatology”

CD80CD86 deficiency causes hair loss by disrupting regulatory T cells.

research The Role of T‐Helper 17 Cells and Regulatory T Cells in Acute Diffuse and Total Alopecia: The Increased Function of Regulatory T Cells May Explain the Favorable Prognosis

1 citations , May 2025 in “The Journal of Dermatology”

Increased regulatory T cell activity may lead to better outcomes in acute diffuse and total alopecia.

research 0009 Regulatory γδ T cells protect human scalp hair follicles from alopecia areata in vivo and represent potential therapeutic target

July 2025 in “Journal of Investigative Dermatology”

γδ T cells can prevent and treat alopecia areata, offering a new therapy option.

research 001 Human scalp hair follicles are protected from alopecia areata in vivo by regulatory γδT cells

November 2024 in “Journal of Investigative Dermatology”

γδT cells can protect hair follicles from alopecia areata and promote hair regrowth.

Human Regulatory Gamma Delta T Lymphocytes as Novel Autoimmunity-Protective Cells: Lessons from Alopecia Areata

research Human regulatory γδT lymphocytes as novel autoimmunity-protective cells: Lessons from alopecia areata

November 2024

γδTregs may help treat autoimmune diseases like alopecia areata by promoting hair regrowth and reducing immune attacks.

Regulatory Gamma Delta T Cells Protect Human Scalp Hair Follicles From Alopecia Areata In Vivo

research 52993 Regulatory γδ T cells protect human scalp hair follicles from alopecia areata in vivo

September 2024 in “Journal of the American Academy of Dermatology”

Regulatory γδ T cells help protect hair follicles from alopecia areata and promote hair regrowth.

research Role of regulatory T cells in pathogenesis and therapeutics of alopecia areata

January 2024 in “Elsevier eBooks”

Increasing regulatory T cells may help treat alopecia areata by reducing autoimmunity and promoting hair growth.

research 185 Regulatory γδ T cells protect human scalp hair follicles from alopecia areata in vivo

November 2023 in “Journal of Investigative Dermatology”

γδTregs can protect hair follicles from alopecia areata and may help regrow hair.

research Early skin seeding regulatory T cells modulate PPARγ-dependent skin pigmentation

October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Early regulatory T cells are crucial for normal skin pigmentation.

research 42905 Role of regulatory T and T-helper 17 cells in patients with acute diffuse and total alopecia

September 2023 in “Journal of the American Academy of Dermatology”

Increased Treg cells and IL-10 may help quick recovery in acute diffuse and total alopecia.

research 068 Pathogenic Th17 cells, CD8+CD69+CD49a- tissue-resident memory T cells and common γ chain receptor + natural killer cells express more IL-17, compared to IFN-γ, under the foxp3+ memory regulatory T cells-depleted microenvironment in patients with chronic alopecia areata

April 2023 in “Journal of Investigative Dermatology”

IL-17 plays a key role in severe hair loss in chronic alopecia areata.

research Regulatory T-Cells: Potential Regulator of Tissue Repair and Regeneration

188 citations , March 2018 in “Frontiers in Immunology”

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.

research Regulatory T Cells: the Many Faces of Foxp3

125 citations , September 2019 in “Journal of Clinical Immunology”

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

Regulatory T Cells in Skin: Role of Foxp3+ CD4+ Tregs in Skin Homeostasis and Immune Tolerance

research Regulatory T cells in skin

110 citations , July 2017 in “Immunology”

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

research Regulatory T cells in inflammatory skin disease: from mice to humans

43 citations , February 2019 in “International immunology”

Special immune cells called Regulatory T cells help control skin inflammation and repair in various skin diseases.

research Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity

39 citations , April 2019 in “The journal of immunology/The Journal of immunology”

Malt1 protease is essential for regulatory T cell function and could be targeted to boost antitumor immunity.

research Regulatory T cells in dominant immunologic tolerance

26 citations , September 2023 in “Journal of Allergy and Clinical Immunology”

Regulatory T cells help prevent autoimmunity and have potential for treating autoimmune diseases.

research Regulatory T cells in autoimmune skin diseases

24 citations , March 2018 in “Experimental Dermatology”

Treg dysfunction is linked to various autoimmune skin diseases, and understanding Treg properties is key for new treatments.