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GlossaryTissue Sectioning

process of cutting thin tissue slices for microscopic examination

Tissue sectioning, also known as microtomy, is the process of cutting thin slices of biological tissue for examination under a microscope. This technique is crucial for studying the detailed structure of tissues, diagnosing diseases, and conducting research. The thin sections, typically only a few micrometers thick, allow for the visualization of cellular and subcellular components when stained and viewed under a microscope.

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Immunofluorescence Tomography: High-Resolution 3D Reconstruction by Serial-Sectioning of Methacrylate Embedded Tissues and Alignment of 2D Immunofluorescence Images

research Immunofluorescence Tomography: High-resolution 3-D reconstruction by serial-sectioning of methacrylate embedded tissues and alignment of 2-D immunofluorescence images

8 citations , February 2019 in “Scientific Reports”

Immunofluorescence tomography is a cost-effective method for creating detailed 3-D images of tissues.

research Comparison betweenMalasseziaFolliculitis and Non-MalasseziaFolliculitis

17 citations , January 2014 in “Annals of Dermatology”

Malassezia folliculitis mainly affects the trunk in males and is better detected with d-PAS staining.

research Watching stem cells at work with a flexible multiphoton tomograph

February 2012 in “Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE”

A new imaging technique can observe stem cells in living mice without harming them.

research C003 Histopathology of the alopecias

September 1997 in “Journal of The European Academy of Dermatology and Venereology”

Examining scalp tissue under a microscope helps diagnose and understand hair loss diseases.

research What’s New in the Histologic Evaluation of Alopecia and Hair-Related Disorders?

4 citations , July 2012 in “Dermatologic Clinics”

New biopsy techniques and tools improve alopecia diagnosis, and both too much and too little selenium can cause hair loss.

research Confocal Laser Scanning Microscopy as a Tool for the Investigation of Skin Drug Delivery Systems and Diagnosis of Skin Disorders

4 citations , March 2013 in “InTech eBooks”

Confocal Laser Scanning Microscopy (CLSM) is a useful tool for studying how drugs interact with skin and diagnosing skin disorders, despite some limitations.

research Preparation of Mohs Micrographic Surgery Frozen Sections: Three New Pearls Leading to a Simplified, More-Effective Process

4 citations , May 2013 in “Dermatologic Surgery”

Three new techniques simplify and improve the preparation of tissue samples for skin cancer surgery.

research Histopathology of Scarring and Nonscarring Hair Loss

17 citations , September 2012 in “Dermatologic Clinics”

The conclusion is that accurate diagnosis of different types of hair loss requires careful examination of tissue samples and understanding of clinical symptoms.

research CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations

6 citations , August 2016 in “Journal of Visualized Experiments”

The CUBIC protocol allows detailed 3D visualization of proteins in mouse skin biopsies.

research Histopathology of alopecia: a clinicopathological approach to diagnosis

170 citations , December 2009 in “Histopathology”

The conclusion is that accurate diagnosis of different types of hair loss requires good teamwork between skin doctors and lab experts.

Development of Modified Montmorillonite-Bacterial Cellulose Nanocomposites as a Novel Substitute for Burn Skin and Tissue Regeneration

research Development of modified montmorillonite-bacterial cellulose nanocomposites as a novel substitute for burn skin and tissue regeneration

93 citations , November 2018 in “Carbohydrate Polymers”

New nanocomposites with copper show promise for healing burn wounds and regenerating skin.

research Stem cells tightly regulate dead cell clearance to maintain tissue fitness

2 citations , May 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Stem cells help remove dead cells to keep tissues healthy by balancing cell replacement and clearance.

research The HoVert technique: a novel method for the sectioning of alopecia biopsies

44 citations , January 2011 in “Journal of Cutaneous Pathology”

The HoVert technique is a simple, cost-effective new method that improves alopecia diagnosis by allowing detailed analysis from a single biopsy.

research Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration

25 citations , June 2021 in “Developmental Cell”

Dying cells can help with faster healing and new hair growth by releasing a growth-promoting molecule.

Injectable Silver Nanoclusters-Based Hydrogel for Wound Healing by Eliminating Bacterial Infection and Promoting Tissue Regeneration

research Injectable Ag nanoclusters-based hydrogel for wound healing via eliminating bacterial infection and promoting tissue regeneration

21 citations , November 2020 in “Chemical Engineering Journal”

The hydrogel with silver and mangiferin helps heal wounds by killing bacteria and aiding skin and tissue repair.

research Applications and Implications of Heparin and Protamine in Tissue Engineering and Regenerative Medicine

15 citations , January 2014 in “BioMed Research International”

Heparin and protamine are promising in tissue repair and organ regeneration, including skin and hair.

research The Effects of Multiple Power Densities of Carbon Dioxide Laser on Photothermal Damage in Rat Skin Tissue

May 2023 in “Current Applied Science and Technology”

Higher power CO2 laser causes more severe skin burns and damage.

research Radioprotection of Lung Tissue by Soy Isoflavones

25 citations , September 2013 in “Journal of thoracic oncology”

Soy isoflavones can protect lung tissue from radiation damage.

Plucked Human Hair as a Tissue to Assess Pharmacodynamic Endpoints During Drug Development Studies

research Plucked human hair as a tissue in which to assess pharmacodynamic end points during drug development studies

23 citations , May 2005 in “British Journal of Cancer”

Plucked human hair can be used to study drug effects on certain cell markers.

research Topical application of synthetic melanin promotes tissue repair

19 citations , November 2023 in “npj Regenerative Medicine”

Synthetic melanin applied to skin speeds up wound healing.

Biochemical and Histopathological Evaluation of Prostatic Tissue Under Effect of Pterostilbene in Benign Prostatic Hyperplasia Rat Model

research Biochemical and Histopathological evaluation of prostatic tissue under effect of Pterostilbene in benign prostatic hyperplasia rat model

2 citations , May 2023 in “Al Mustansiriyah Journal of Pharmaceutical Sciences”

Pterostilbene significantly reduces prostate enlargement and has strong antioxidant effects.

research The Role of Vimentin in Tissue Repair and Cell Growth

January 2023 in “Åbo Akademi University Research Portal”

Vimentin is crucial for wound healing, cell growth, and managing immune responses.

research 4D polycarbonates via stereolithography as scaffolds for soft tissue repair

101 citations , July 2021 in “Nature Communications”

4D polycarbonate scaffolds show promise for soft tissue repair due to their biocompatibility, shape memory, and minimal immune response.

Development and Molecular Characterization of Human Placental Mesenchymal Stem Cells from Aborted Fetal Tissue as a Model to Study Mechanism of Spontaneous Abortion

research Development and Molecular Characterization of Human Placental Mesenchymal Stem Cells from Human Aborted Fetal Tissue as a Model to Study Mechanism of Spontaneous Abortion

3 citations , February 2014 in “Advances in Stem Cells”

Placenta-derived stem cells can help study and treat spontaneous abortion.

Stimulation of the Follicular Bulge LGR5+ and LGR6+ Stem Cells with the Gut-Derived Human Alpha Defensin 5 Results in Decreased Bacterial Presence, Enhanced Wound Healing, and Hair Growth from Tissues Devoid of Adnexal Structures

research Stimulation of the Follicular Bulge LGR5+ and LGR6+ Stem Cells with the Gut-Derived Human Alpha Defensin 5 Results in Decreased Bacterial Presence, Enhanced Wound Healing, and Hair Growth from Tissues Devoid of Adnexal Structures

39 citations , October 2013 in “Plastic and Reconstructive Surgery”

Human alpha defensin 5 helps heal wounds, reduce bacteria, and grow hair on burned skin.

research The Transverse Anatomy of Androgenic Alopecia

42 citations , December 1990 in “The Journal of Dermatologic Surgery and Oncology”

The study found that horizontal sections of scalp biopsies are better for analyzing hair loss, showing fewer hairs and more fine hairs in balding areas.

research The influence of CD26+ and CD26− fibroblasts on the regeneration of human dermo-epidermal skin substitutes

11 citations , February 2022 in “Scientific Reports”

CD26+ fibroblasts improve skin healing and integration better than CD26− fibroblasts.

research Effect of decellularisation methods on methacryloyl-substituted placental ECM hydrogels

January 2020

PlacMA hydrogels from human placenta are versatile and useful for cell culture and tissue engineering.

Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987

research Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987

January 1989 in “Clinical and Experimental Dermatology”

The symposium concluded that hair growth involves complex processes, including the hair follicle life cycle, the role of the dermal papilla, hair strength, pigmentation, and the impact of diseases and treatments like minoxidil on hair and skin.

research Three-dimensional model of normal human dermal tissue using serial tissue sections

5 citations , March 2024 in “Frontiers in Bioengineering and Biotechnology”

A detailed 3D model of human skin was created to help develop artificial skin.