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GlossaryVascularization

process of forming new blood vessels in tissue

Vascularization refers to the process by which new blood vessels form within a tissue. This is crucial for delivering oxygen and nutrients to tissues, promoting healing, and supporting the growth of new cells. In the context of hair and alopecia, proper vascularization of the scalp is essential for healthy hair growth, as it ensures that hair follicles receive the necessary nutrients and oxygen.

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The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization, and Hair Growth in a Porcine Model

research The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization and Hair Growth in a Porcine Model

16 citations , April 2016 in “PLoS ONE”

Negative pressure treatment improved skin thickness, blood vessel growth, and hair growth.

research Macrophages are necessary for skin regeneration during tissue expansion

44 citations , January 2019 in “Journal of Translational Medicine”

Macrophages are essential for successful skin growth in reconstructive surgery.

research A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro?

133 citations , July 2020 in “Cells”

Creating fully functional artificial skin for chronic wounds is still very challenging.

research Tissue engineering of human hair follicles using a biomimetic developmental approach

184 citations , December 2018 in “Nature Communications”

Researchers created human hair follicles using a new method that could help treat hair loss.

Successive Release of Tissue Inhibitors of Metalloproteinase-1 Through Graphene Oxide-Based Delivery System Can Promote Skin Regeneration

research Successive Release of Tissue Inhibitors of Metalloproteinase-1 Through Graphene Oxide-Based Delivery System Can Promote Skin Regeneration

9 citations , September 2017 in “Nanoscale Research Letters”

Graphene oxide helps deliver a skin healing agent over time, improving skin and hair follicle regeneration.

research In Vitro Culture Methods of Skin Cells for Optimal Skin Reconstruction by Tissue Engineering

2 citations , August 2011 in “InTech eBooks”

New methods for growing skin cells can improve skin grafts by building blood vessels within them.

research Role of Growth Factors-Rich Plasma, Gel and Membrane in Dermal Wound Healing and Injured Tissue Restoration and Regeneration

1 citations , November 2021 in “European journal of medical and health sciences”

Growth factors-rich plasma treatments can significantly speed up wound healing and tissue regeneration.

research Biocompatibility of tissue engineering scaffolds made from keratin biomaterials

1 citations , March 2006 in “The FASEB journal”

Keratin-based scaffolds are safe and effective for tissue engineering.

research Biological Roles and Prospects of using Adipose Tissue Derivatives and Platelet-Rich Plasma in Surgical Practice: A Review

May 2025 in “The Open Biomedical Engineering Journal”

Adipose tissue and PRP together improve healing and surgery outcomes but need more research for consistent use.

research Hair Growth Promoting Effect of Dermal Papilla Like Tissues from Canine Adipose-Derived Mesenchymal Stem Cells in Athymic Nude Mice

January 2016

Tissue from dog stem cells helped grow hair in mice.

research Multipotent adult progenitor cells grown under xenobiotic-free conditions support vascularization during wound healing

4 citations , September 2020 in “Stem Cell Research & Therapy”

Xenobiotic-free progenitor cells improve wound healing and blood vessel formation.

research Head and Neck 3D Bioprinting—A Review on Recent Advancements in Soft Tissue 3D Bioprinting and Medical Applications

5 citations , June 2025 in “Journal of Functional Biomaterials”

3D bioprinting offers new ways to treat head and neck defects with bioinks that mimic natural tissues.

research 3D multicellular micropatterning biomaterials for hair regeneration and vascularization

3 citations , January 2023 in “Materials horizons”

The new biomaterial helps grow blood vessels and hair for skin repair.

research [Skin tissue engineering in China].

1 citations , October 2008 in “PubMed”

China made major progress in creating artificial skin for better burn treatment.

research Surgical Anatomy of the Scalp

July 2002 in “Dermatologic Surgery”

Understanding the scalp's five-layer structure is crucial for better surgical outcomes and fewer complications.

research Asymmetric adhesive SIS-based wound dressings for therapeutically targeting wound repair

13 citations , January 2024 in “Journal of Nanobiotechnology”

The new wound dressing improves healing and tissue repair better than conventional dressings.

Gelatin-Chondroitin-6-Sulfate-Hyaluronic Acid Scaffold Seeded with Vascular Endothelial Growth Factor 165 Modified Hair Follicle Stem Cells as a Three-Dimensional Skin Substitute

research Gelatin-chondroitin-6-sulfate-hyaluronic acid scaffold seeded with vascular endothelial growth factor 165 modified hair follicle stem cells as a three-dimensional skin substitute

45 citations , October 2014 in “Stem cell research & therapy”

Modified rat stem cells on a special scaffold improved blood vessel formation and wound healing in skin substitutes.

research The Angiogenic Potential of Mesenchymal Stem Cells from the Hair Follicle Outer Root Sheath

8 citations , February 2021 in “Journal of Clinical Medicine”

Hair follicle stem cells are promising for blood vessel formation and tissue repair.

research Efficiency and safety of autologous platelet-rich plasma

May 2025 in “Medicine and ecology”

The effectiveness of platelet-rich plasma is unclear due to inconsistent preparation methods.

research Injectable Polypeptide‐Protein Hydrogels for Promoting Infected Wound Healing

262 citations , May 2020 in “Advanced Functional Materials”

The hydrogel promotes faster healing of infected wounds by enhancing tissue regeneration and preventing infection.

research Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration

24 citations , October 2024 in “International Journal of Extreme Manufacturing”

3D skin bioprinting has advanced but still faces challenges like safety and the need for better integration with sensors.

research Effect of Topical Linum usitatissimum on Full Thickness Excisional Skin Wounds

15 citations , September 2016 in “Trauma Monthly”

Linum usitatissimum gel improves wound healing and tissue regeneration.

research The influence of CD26+ and CD26− fibroblasts on the regeneration of human dermo-epidermal skin substitutes

11 citations , February 2022 in “Scientific Reports”

CD26+ fibroblasts improve skin healing and integration better than CD26− fibroblasts.

research Hydrogel-mediated extracellular vesicles for enhanced wound healing: the latest progress, and their prospects for 3D bioprinting

1 citations , February 2024 in “Journal of nanobiotechnology”

Hydrogels combined with extracellular vesicles and 3D bioprinting improve wound healing.

research Skin Organoids for Disease Modelling, Drug Screening and Regenerative Medicine: Recent Advances and Future Perspectives

January 2026 in “Wound Repair and Regeneration”

Skin organoids are improving research but need better blood supply, nerve function, and immune system integration.

All-In-One Polysaccharide Hydrogel With Resistant Vascular Burst Pressure And Cooperative Wound Microenvironment Regulation For Fatal Arterial Hemorrhage And Diabetic Wound Healing

research All-in-one polysaccharide hydrogel with resistant vascular burst pressure and cooperative wound microenvironment regulation for fatal arterial hemorrhage and diabetic wound healing

June 2024 in “International journal of biological macromolecules”

The hydrogel effectively stops bleeding and heals diabetic wounds quickly.

research 3D bioprinting in plastic and reconstructive surgery: current concepts, progress, and clinical application

August 2023 in “European Journal of Plastic Surgery”

3D bioprinting is advancing in plastic and reconstructive surgery, especially for creating tissues and improving surgical planning, but faces challenges like vascularization and material development.

research Histological evaluation of hair keratin based templates in mice

January 2017 in “DR-NTU (Nanyang Technological University)”

Keratin sponges are as biocompatible as collagen, but keratin gels are slightly less so.

Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

research Impact of the Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma (A-PRP) and Activated Platelet-Rich Plasma (AA-PRP) in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

58 citations , January 2020 in “International Journal of Molecular Sciences”

Different methods of preparing Platelet-Rich Plasma (PRP) can affect wound healing and hair regrowth in plastic surgery. Using a kit with specific standards helps isolate PRP that meets quality criteria. Non-Activated PRP and Activated PRP have varying effects depending on the tissue and condition treated. For hair regrowth, Non-Activated PRP increased hair density more than Activated PRP. Both treatments improved various aspects of scalp health.

research Shh pathway in wounds in non-diabetic Shh-Cre-eGFP/Ptch1-LacZ mice treated with MAA beads

14 citations , June 2016 in “Biomaterials”

MAA beads improved wound healing in male mice by activating the Shh pathway, but not in females.