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The Relative Effect of Monotherapy with 5-Alpha Reductase Inhibitors and Minoxidil for Female Pattern Hair Loss: A Network Meta-Analysis Study

research The relative effect of monotherapy with 5‐alpha reductase inhibitors and minoxidil for female pattern hair loss: A network meta‐analysis study

June 2023 in “Journal of Cosmetic Dermatology”

Finasteride 5mg daily is the most effective for female pattern hair loss, with higher doses of treatments generally more effective.

research Androgenetic Alopecia Treated With Topical Minoxidil. A Case Report and Review of Treatment Options

January 2023 in “International Journal of Medicine in Developing Countries”

Topical minoxidil improved hair loss in a patient when used consistently.

Topical Minoxidil Fortified with Finasteride: Maintenance of Hair Density After Replacing Oral Finasteride

research Topical minoxidil fortified with finasteride: An account of maintenance of hair density after replacing oral finasteride

August 2016 in “International journal of scientific research”

Using minoxidil with finasteride in a cream helps maintain hair thickness after stopping oral finasteride.

research The use of liposomes in the topical application of steroids

33 citations , May 1984 in “Journal of Pharmacy and Pharmacology”

Liposomes are not better than acetone for applying DHT on skin.

research A Phase III, Multicenter, Parallel-Design Clinical Trial to Compare the Efficacy and Safety of 5% Minoxidil Foam Versus Vehicle in Women With Female Pattern Hair Loss.

1 citations , July 2016 in “PubMed”

5% minoxidil foam is effective and safe for hair regrowth in women with hair loss.

research Successful treatment of generalized discoid lupus erythematosus with imiquimod cream 5%: a case report and review of the literature.

24 citations , January 2014 in “PubMed”

Imiquimod cream 5% effectively treated generalized discoid lupus erythematosus.

research The pink tax: gender-based cost disparities of topical minoxidil

1 citations , July 2025 in “International Journal of Women’s Dermatology”

Women's minoxidil products cost more and are less effective than men's.

Hair Are the Rankings—5-Alpha Reductase Inhibitors and Minoxidil in Male Androgenetic Alopecia

research Hair Are the Rankings—5-α Reductase Inhibitors and Minoxidil in Male Androgenetic Alopecia

1 citations , February 2022 in “JAMA Dermatology”

Minoxidil and finasteride are FDA-approved treatments for male hair loss, but off-label use of oral minoxidil, dutasteride, and higher doses of finasteride and minoxidil is increasing.

research A New Era of 5α-Reductase Inhibitors for Androgenetic Alopecia

1 citations , January 2015 in “Hair therapy & transplantation”

New drug dutasteride effectively treats hair loss, but use cautiously due to potential sexual side effects.

research Sexual dysfunction associated with 5α-reductase inhibitors in the treatment of androgenetic alopecia: a systematic review

June 2026 in “Frontiers in Medicine”

This systematic review examines the sexual dysfunction associated with 5α-reductase inhibitors (5-ARIs) used for treating androgenetic alopecia (AGA). Analyzing 41 studies, it finds that sexual adverse events, such as decreased libido and erectile dysfunction, occur in 1.9–6.7% of men taking oral finasteride and 4.1–12.0% for dutasteride, with lower rates for topical finasteride. These effects are generally mild, reversible, and not consistently reported in women. Clinicians should inform patients about these potential side effects, emphasizing their infrequency and reversibility, while advocating for shared decision-making and further research to better understand individual susceptibility and long-term risks.

research Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, InVitro, and In Silico Studies

August 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.

research TOPICAL PHARMACEUTICAL COMPOSITIONS

January 2023 in “CINECA IRIS Institutial research information system (University of Pisa)”

The composition helps treat hair loss.

What Do We Know About 5-Alpha Reductase Inhibitors?

research O que sabemos sobre os inibidores da 5 alfa redutase?

January 2018 in “Surgical and Cosmetic Dermatology”

Finasteride and dutasteride are effective for male hair loss and enlarged prostate but may cause reversible sexual side effects.

research Minoxidil: main differences between topical and oral use

February 2023 in “Seven Editora eBooks”

Oral minoxidil has more side effects but can be more effective than topical minoxidil.

research Comparison between “5% minoxidil plus 2% flutamide” solution vs. “5% minoxidil” solution in the treatment of androgenetic alopecia

February 2022 in “Journal of Cosmetic Dermatology”

Using both minoxidil and flutamide together is more effective for treating hair loss than using minoxidil alone.

research Topical minoxidil for androgenetic alopecia in women:a systematic review

January 2012 in “Sichuan Medical Journal”

2% minoxidil effectively increases hair count in women with androgenetic alopecia without severe side effects.

research [Artículo traducido] Características clínicas y sociodemográficas de la alopecia areata en 5 ciudades colombianas: un análisis del RENAAC

1 citations , September 2024 in “Actas Dermo-Sifiliográficas”

Alopecia areata is more common in women, often appears as patchy hair loss, and is usually treated with steroid injections and minoxidil.

Efficacy and Safety of Intralesional Platelet-Rich Plasma Compared to 5% Topical Minoxidil in the Treatment of Male Androgenetic Alopecia Affecting the Vertex

research Eficacia y seguridad del plasma rico en plaquetas intralesional comparado con minoxidil al 5% tópico en el tratamiento de la alopecia androgenética masculina con afectación en vértex

January 2022 in “Revista del Centro Dermatológico Pascua”

PRP therapy is a promising treatment for male hair loss on the vertex.

Clinical Trial and In Vitro Study Investigating Topical Application of Zataria Multiflora Boiss. and Matricaria Chamomilla Extracts for Androgenetic Alopecia

research Clinical trial and in vitro study investigating topical application of Zataria multiflora Boiss. and Matricaria chamomilla extracts for androgenetic alopecia

January 2017 in “Cogent Medicine”

Extracts improve hair growth in alopecia.

research Sebaceous glands changes following topical application of citral

14 citations , September 1983 in “Acta Dermato Venereologica”

Citral increases sebaceous gland activity in male rats.

research Minoxidil 1 mg orally versus minoxidil 5% solution topically for the treatment of female pattern hair loss: a randomized clinical trial

October 2019 in “UNESP Institutional Repository (São Paulo State University)”

Oral minoxidil 1 mg is effective and safe for female hair loss, with less shedding but more hair growth on the body.

research In Vitro and In Vivo Skin Distribution of 5α-Reductase Inhibitors Loaded Into Liquid Crystalline Nanoparticles

32 citations , June 2017 in “Journal of Pharmaceutical Sciences”

Chitosan-coated nanoparticles improve skin delivery of hair loss treatments with fewer side effects.

research Treatment of androgenetic alopecia with a 7.5% herbal preparation

10 citations , January 1996 in “Journal of Dermatological Treatment”

Herbal preparation effectively promotes hair growth and reduces hair loss.

Comparing the Effectiveness of Local Solution of Minoxidil and Caffeine 2.5% with Local Solution of Minoxidil 2.5% in Treatment of Androgenetic Alopecia

research Comparing the Effectiveness of Local Solution of Minoxidil and Caffeine 2.5% with Local Solution of Minoxidil 2.5% in Treatment of Androgenetic Alopecia

November 2013 in “Journal of Mazandaran University of Medical Sciences”

Minoxidil with caffeine works better for hair loss than minoxidil alone.

Interconnected Polymers Technology (IPSTiC): An Effective Approach for the Modulation of 5α-Reductase Activity in Hair Loss Conditions

research Interconnected PolymerS TeChnology (IPSTiC): An Effective Approach for the Modulation of 5α-Reductase Activity in Hair Loss Conditions

7 citations , July 2018 in “Journal of Functional Biomaterials”

A new anti-baldness patch effectively treats hair loss by blocking enzymes linked to the condition.

The Skin Findings of Pregnant Women and Our Treatment Choices: A Turkish Experience Over a 5-Year Survey

research Activity of 17β-(N-Alkyl/arylformamido) and 17β-[(N-Alkyl/aryl) alkyl/arylamido]-4-methyl-4-aza-5α-androstan-3-ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear11The research has been supported by Endorecherche that is seeking patent protection for the new compounds. F. Labrie is President of Endorecherche.

10 citations , August 1998 in “Journal of Investigative Dermatology”

The compounds tested could potentially treat hair loss and alopecia.

research 519 Design of a new molecule proven to be safe and effective for topical depigmenting and antiaging method

November 2022 in “Journal of Investigative Dermatology”

A new molecule was found to be a safe and effective skin lightener and anti-aging product.

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