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Glossarytranscriptome

complete set of RNA molecules expressed in a cell

The transcriptome is the complete set of RNA molecules, including messenger RNA (mRNA), produced in a cell or a population of cells. It reflects the genes that are actively being expressed at any given time, providing insights into cellular function and regulation. For professionals, analyzing the transcriptome can reveal how cells respond to various conditions and can be crucial for understanding diseases like alopecia at a molecular level.

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research Comprehensive transcriptome and methylome analysis delineates the biological basis of hair follicle development and wool-related traits in Merino sheep

112 citations , September 2021 in “BMC Biology”

Key genes and factors crucial for hair follicle development and wool traits in Merino sheep were identified.

research Transcriptome Sequencing Reveals Differences between Primary and Secondary Hair Follicle-derived Dermal Papilla Cells of the Cashmere Goat (Capra hircus)

81 citations , September 2013 in “PLoS ONE”

Primary and secondary hair follicle cells in Cashmere goats have different gene expressions affecting hair growth and size.

research Analyses of histological and transcriptome differences in the skin of short-hair and long-hair rabbits

59 citations , February 2019 in “BMC Genomics”

Hair length in rabbits is linked to differences in lipid metabolism and cell death.

research Transcriptome Profile at Different Physiological Stages Reveals Potential Mode for Curly Fleece in Chinese Tan Sheep

55 citations , August 2013 in “PloS one”

Genetic differences between young and old Tan sheep explain why their fleece changes from curly to straight as they age.

Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

research Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22

52 citations , May 2015 in “PLOS Genetics”

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

research Transcriptional Characteristics Showed That miR-144-y/FOXO3 Participates in Embryonic Skin and Feather Follicle Development in Zhedong White Goose

46 citations , August 2022 in “Animals”

miR-144-y and FOXO3 play key roles in skin and feather development in Zhedong White geese.

research Transcriptome Reveals Long Non-coding RNAs and mRNAs Involved in Primary Wool Follicle Induction in Carpet Sheep Fetal Skin

37 citations , May 2018 in “Frontiers in physiology”

Certain RNA molecules are important for the development of wool follicles in sheep.

Comparative Transcriptome Analysis Reveals That a Ubiquitin-Mediated Proteolysis Pathway Is Important for Primary and Secondary Hair Follicle Development in Cashmere Goats

research Comparative Transcriptome Analysis Reveals that a Ubiquitin-Mediated Proteolysis Pathway Is Important for Primary and Secondary Hair Follicle Development in Cashmere Goats

31 citations , October 2016 in “PLoS ONE”

The ubiquitin-mediated proteolysis pathway is crucial for hair follicle development in cashmere goats.

Differential Gene Expression Analysis Between Anagen and Telogen of Capra Hircus Skin Based on the De Novo Assembled Transcriptome Sequence

research Differential gene expression analysis between anagen and telogen of Capra hircus skin based on the de novo assembled transcriptome sequence

31 citations , March 2013 in “Gene”

Signaling pathways are crucial for hair growth in goats.

Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat

research Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat

24 citations , April 2020 in “Cells”

DNA methylation and long non-coding RNAs are key in controlling hair growth in Cashmere goats.

research Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo

23 citations , March 2023 in “eLife”

Stem cell differentiation involves gradual chromatin changes and dynamic gene activity.

research Transcriptome-based selection and validation of optimal house-keeping genes for skin research in goats (Capra hircus)

23 citations , July 2020 in “BMC Genomics”

NCBP3, SDHA, and PTPRA are the best genes for accurate goat skin research.

research The fiber diameter traits of Tibetan cashmere goats are governed by the inherent differences in stress, hypoxic, and metabolic adaptations: an integrative study of proteome and transcriptome

17 citations , March 2022 in “BMC Genomics”

Cashmere fiber diameter in Tibetan goats is influenced by their stress, oxygen, and metabolic adaptations.

research Transcriptome analysis reveals improved root hair growth in trifoliate orange seedlings by arbuscular mycorrhizal fungi

16 citations , May 2020 in “Plant Growth Regulation”

research Transcriptional profiling of putative human epithelial stem cells

16 citations , July 2008 in “BMC Genomics”

Alpha 6 + /MHCI - cells have stem cell traits and are similar to mouse hair follicle stem cells.

Transcriptional Activation of CCN1 and CCN2, Targets of Canonical Wnt Signal, by Ascorbic Acid 2-Phosphate in Human Dermal Papilla Cells

research Transcriptional activation of CCN1 and CCN2, targets of canonical Wnt signal, by ascorbic acid 2-phosphate in human dermal papilla cells

14 citations , November 2007 in “Journal of Dermatological Science”

Vitamin C derivative may promote hair growth by activating specific genes.

research Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling

13 citations , September 2022 in “Biomolecules”

The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.

research Distinct Transcriptional Profiles of the Female, Male, and Finasteride-Induced Feminized Male Anogenital Region in Rat Fetuses

10 citations , February 2019 in “Toxicological Sciences”

Finasteride exposure affects gene expression and anogenital distance in male rat fetuses.

research Transcriptome Analysis Reveals Skin Lipid Metabolism Related to Wool Diameter in Sheep

10 citations , May 2016 in “bioRxiv (Cold Spring Harbor Laboratory)”

Lipid metabolism affects wool thickness in sheep.

research Transcriptional Profiling in Rat Hair Follicles following Simulated Blast Insult: A New Diagnostic Tool for Traumatic Brain Injury

10 citations , August 2014 in “PLoS ONE”

Hair follicles can help diagnose traumatic brain injury quickly and non-invasively.

research Evaluation of noninvasive biospecimens for transcriptome studies

9 citations , December 2023 in “BMC Genomics”

Hair follicles and urine cell pellets are promising for transcriptome studies.

research Transcriptome Profiling of Human Follicle Dermal Papilla Cells in response to Porphyra-334 Treatment by RNA-Seq

7 citations , January 2021 in “Evidence-based complementary and alternative medicine”

Porphyra-334 may help reduce wrinkles and promote hair growth.

research Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis

7 citations , August 2020 in “Genes”

Different genes are active in dogs' hair growth and skin, similar to humans, which helps understand dog skin and hair diseases and can relate to human conditions.

research Transcriptome profiling of whisker follicles in methamphetamine self-administered rats

6 citations , July 2018 in “Scientific Reports”

Methamphetamine affects gene expression in rat whisker follicles, with key genes linked to addiction.

research Integrative analysis of Iso-Seq and RNA-seq data reveals transcriptome complexity and differential isoform in skin tissues of different hair length Yak

5 citations , May 2024 in “BMC Genomics”

Different genes affect hair length in yaks.

Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth

research Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth

5 citations , September 2021 in “Frontiers in Cell and Developmental Biology”

Dihydrotestosterone treatment on 2D and 3D-cultured skin cells slows down hair growth by affecting certain genes and could be a potential target for hair loss treatment.

research Transcriptome Analysis of Improved Wool Production in Skin-Specific Transgenic Sheep Overexpressing Ovine β-Catenin

4 citations , January 2019 in “International journal of molecular sciences”

Genetically modified sheep with more β-catenin grew more wool without changing the wool's length or thickness.